International Journal of Biological Macromolecules, Год журнала: 2024, Номер 269, С. 131879 - 131879
Опубликована: Апрель 29, 2024
Язык: Английский
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 269, С. 131879 - 131879
Опубликована: Апрель 29, 2024
Язык: Английский
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Апрель 15, 2024
Abstract Hydrogels are a class of highly absorbent and easily modified polymer materials suitable for use as slow-release carriers drugs. Gene therapy is specific can overcome the limitations traditional tissue engineering techniques has significant advantages in repair. However, therapeutic genes often affected by cellular barriers enzyme sensitivity, carrier loading essential. Therapeutic gene hydrogels well these difficulties. Moreover, gene-therapeutic have made considerable progress. This review summarizes recent research on treatment damage through summary most current frontiers. We initially introduce classification their cross-linking methods, followed detailed overview types modifications genes, discussion characterization features, design release, an applications engineering. Finally, we provide comments look forward to shortcomings future directions therapy. hope that this article will researchers related fields with more comprehensive systematic strategies repair further promote development field Graphical abstract
Язык: Английский
Процитировано
17Materials Today Physics, Год журнала: 2024, Номер 43, С. 101397 - 101397
Опубликована: Март 19, 2024
Язык: Английский
Процитировано
14IntechOpen eBooks, Год журнала: 2024, Номер unknown
Опубликована: Май 23, 2024
Conventional therapeutic models based on the premise of a universal solution are facing decrease in efficiency, emphasized by large number patients who show resistance or do not respond positively to classic treatments. This perspective highlights urgency for more precise approaches personalized treatments that adaptable specific complexities and unique challenges faced each patient. Hydrogels biocompatible biodegradable systems well-controlled targeted administration agents, being formed 3D reticulated networks water-soluble polymeric biomaterials, natural, synthetic, hybrid origin, with intrinsic extrinsic properties. Due easily adjustable porous structure, hydrogels allow encapsulation macromolecular drugs, proteins, small molecules, cells, hormones, growth factors gel matrix their subsequent controlled release. The biomaterials used, crosslinking methods, design, functionalization strategies obtaining improved properties presented. different possibilities application described transdermally, as dressing materials, oral, ocular, spray-able, injectable, up intracellular level. chapter extensively investigates advances advantages enable effective, noninvasive, provide greater patient comfort wide range applications.
Язык: Английский
Процитировано
10Acta Biomaterialia, Год журнала: 2024, Номер 178, С. 265 - 286
Опубликована: Фев. 27, 2024
Язык: Английский
Процитировано
9Pharmaceutics, Год журнала: 2024, Номер 16(3), С. 359 - 359
Опубликована: Март 4, 2024
The plant material Scutellariae baicalensis radix, which is rich in flavones (baicalin), possesses antibacterial, antifungal, antioxidant, and anti-inflammatory properties. This work aimed to develop a 3D-printed chitosan-based hydrogel extract as an innovative approach for the personalized treatment of periodontal diseases. Chitosan-based hydrogels were prepared, printability prepared was determined. with 2.5% w/v high molecular-weight chitosan (CS), 2% gelatin (Gel), 10% w/w (Ex) presented best printability, producing smooth uniform scaffolds. It proved that CS/Gel/Ex stabilized by hydrogen bonds remained amorphous dispersion structures (confirmed ATR-FTIR XRPD). Due amorphization active substance, significant increase release baicalin vitro observed. demonstrated there initial burst continuous profile (n = 3). Higuchi kinetic most likely kinetic. second fit, Korsmeyer–Peppas kinetics model, showed coupled diffusion ingredient hydrated matrix polymer relaxation regulated release, n values ranging from 0.45 0.89. properties scaffolds assessed ability inhibit activity hyaluronidase enzyme. Activity IC50 63.57 ± 4.98 mg hydrogel/mL 6). Cytotoxicity tests biocompatibility material. After 24 h exposure 2.5CS/2Gel/10Ex scaffold, fibroblasts migrated toward scratch, closed “wound” 97.1%, significantly accelerated wound healing process. results render CS/Gel/extract potential candidates treating
Язык: Английский
Процитировано
9Materials Today Bio, Год журнала: 2024, Номер 29, С. 101265 - 101265
Опубликована: Сен. 23, 2024
Язык: Английский
Процитировано
9Biomaterials Advances, Год журнала: 2025, Номер 169, С. 214176 - 214176
Опубликована: Янв. 9, 2025
Язык: Английский
Процитировано
1International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142134 - 142134
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
1Carbohydrate Polymers, Год журнала: 2024, Номер 348, С. 122864 - 122864
Опубликована: Окт. 16, 2024
Язык: Английский
Процитировано
8International Journal of Biological Macromolecules, Год журнала: 2024, Номер 269, С. 131772 - 131772
Опубликована: Апрель 24, 2024
Язык: Английский
Процитировано
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