Developing hydrogels for gene therapy and tissue engineering

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Апрель 15, 2024

Abstract Hydrogels are a class of highly absorbent and easily modified polymer materials suitable for use as slow-release carriers drugs. Gene therapy is specific can overcome the limitations traditional tissue engineering techniques has significant advantages in repair. However, therapeutic genes often affected by cellular barriers enzyme sensitivity, carrier loading essential. Therapeutic gene hydrogels well these difficulties. Moreover, gene-therapeutic have made considerable progress. This review summarizes recent research on treatment damage through summary most current frontiers. We initially introduce classification their cross-linking methods, followed detailed overview types modifications genes, discussion characterization features, design release, an applications engineering. Finally, we provide comments look forward to shortcomings future directions therapy. hope that this article will researchers related fields with more comprehensive systematic strategies repair further promote development field Graphical abstract

Язык: Английский

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Small functional hydrogels with big engineering applications

Materials Today Physics, Год журнала: 2024, Номер 43, С. 101397 - 101397

Опубликована: Март 19, 2024

Язык: Английский

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Biomaterials-based hydrogels for therapeutic applications

IntechOpen eBooks, Год журнала: 2024, Номер unknown

Опубликована: Май 23, 2024

Conventional therapeutic models based on the premise of a universal solution are facing decrease in efficiency, emphasized by large number patients who show resistance or do not respond positively to classic treatments. This perspective highlights urgency for more precise approaches personalized treatments that adaptable specific complexities and unique challenges faced each patient. Hydrogels biocompatible biodegradable systems well-controlled targeted administration agents, being formed 3D reticulated networks water-soluble polymeric biomaterials, natural, synthetic, hybrid origin, with intrinsic extrinsic properties. Due easily adjustable porous structure, hydrogels allow encapsulation macromolecular drugs, proteins, small molecules, cells, hormones, growth factors gel matrix their subsequent controlled release. The biomaterials used, crosslinking methods, design, functionalization strategies obtaining improved properties presented. different possibilities application described transdermally, as dressing materials, oral, ocular, spray-able, injectable, up intracellular level. chapter extensively investigates advances advantages enable effective, noninvasive, provide greater patient comfort wide range applications.

Язык: Английский

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pH-responsive CuS/DSF/EL/PVP nanoplatform alleviates inflammatory bowel disease in mice via regulating gut immunity and microbiota

Acta Biomaterialia, Год журнала: 2024, Номер 178, С. 265 - 286

Опубликована: Фев. 27, 2024

Язык: Английский

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3D-Printed Chitosan-Based Scaffolds with Scutellariae baicalensis Extract for Dental Applications

Pharmaceutics, Год журнала: 2024, Номер 16(3), С. 359 - 359

Опубликована: Март 4, 2024

The plant material Scutellariae baicalensis radix, which is rich in flavones (baicalin), possesses antibacterial, antifungal, antioxidant, and anti-inflammatory properties. This work aimed to develop a 3D-printed chitosan-based hydrogel extract as an innovative approach for the personalized treatment of periodontal diseases. Chitosan-based hydrogels were prepared, printability prepared was determined. with 2.5% w/v high molecular-weight chitosan (CS), 2% gelatin (Gel), 10% w/w (Ex) presented best printability, producing smooth uniform scaffolds. It proved that CS/Gel/Ex stabilized by hydrogen bonds remained amorphous dispersion structures (confirmed ATR-FTIR XRPD). Due amorphization active substance, significant increase release baicalin vitro observed. demonstrated there initial burst continuous profile (n = 3). Higuchi kinetic most likely kinetic. second fit, Korsmeyer–Peppas kinetics model, showed coupled diffusion ingredient hydrated matrix polymer relaxation regulated release, n values ranging from 0.45 0.89. properties scaffolds assessed ability inhibit activity hyaluronidase enzyme. Activity IC50 63.57 ± 4.98 mg hydrogel/mL 6). Cytotoxicity tests biocompatibility material. After 24 h exposure 2.5CS/2Gel/10Ex scaffold, fibroblasts migrated toward scratch, closed “wound” 97.1%, significantly accelerated wound healing process. results render CS/Gel/extract potential candidates treating

Язык: Английский

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Photo-crosslinking Injectable Photothermal Antibacterial hydrogel based on Quaternary Ammonium Grafted Chitosan and Hyaluronic Acid for Infected Wound Healing

Materials Today Bio, Год журнала: 2024, Номер 29, С. 101265 - 101265

Опубликована: Сен. 23, 2024

Язык: Английский

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Adhesive transparent antimicrobial quaternized chitosan/oxidized dextran/polydopamine nanoparticle hydrogels for accelerated wound healing

Biomaterials Advances, Год журнала: 2025, Номер 169, С. 214176 - 214176

Опубликована: Янв. 9, 2025

Язык: Английский

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Advances in the study of polysaccharide-based hydrogel wound dressings

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142134 - 142134

Опубликована: Март 1, 2025

Язык: Английский

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Injectable self-healing alginate/PEG hydrogels cross-linked via thiol-Michael addition bonds for hemostasis and wound healing

Carbohydrate Polymers, Год журнала: 2024, Номер 348, С. 122864 - 122864

Опубликована: Окт. 16, 2024

Язык: Английский

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Advances of biological macromolecules hemostatic materials: A review

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 269, С. 131772 - 131772

Опубликована: Апрель 24, 2024

Язык: Английский

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