Foods,
Год журнала:
2024,
Номер
13(24), С. 4045 - 4045
Опубликована: Дек. 14, 2024
Advanced
glycation
end
products
(AGEs)
are
produced
in
foods
during
their
thermal
treatment
through
routes
like
the
Maillard
reaction.
They
have
been
linked
to
various
health
issues
such
as
diabetes,
neurodegenerative
disorders,
and
cardiovascular
diseases.
There
multiple
pathways
which
AGEs
can
form
body.
Therefore,
this
review
work
aims
explore
formation
of
gain
insights
into
generation
mechanisms.
Furthermore,
has
analyzed
recent
trends
detection
inhibition
food
matrices.
It
be
highlighted,
based
on
surveyed
literature,
that
UHPLC-Orbitrap-Q-Exactive-MS
UPLC-ESI-MS/MS
produce
highly
sensitive
results
with
a
low
limit
levels
for
Moreover,
works
inhibitory
agents
spices,
herbs,
fruits,
vegetables,
hydrocolloids,
plasma-activated
water,
probiotic
bacteria
were
assessed
capacity
suppress
simulation
models.
Overall,
it
is
essential
decrease
occurrence
products,
future
scope
might
include
studying
interaction
macromolecular
components
minimize
production
without
sacrificing
organoleptic
qualities
processed
foods.
Foods,
Год журнала:
2024,
Номер
13(15), С. 2417 - 2417
Опубликована: Июль 30, 2024
Drying
conditions
significantly
impact
the
compositions
and
microstructures
of
polysaccharides,
leading
to
various
effects
on
their
chemical
characteristics
bioactivities.
The
objective
this
study
was
investigate
how
different
industrial
drying
techniques,
i.e.,
hot
air
drying,
infrared
microwave
vacuum
freeze
affect
structural
properties
biological
activities
polysaccharides
extracted
from
Foods,
Год журнала:
2025,
Номер
14(2), С. 238 - 238
Опубликована: Янв. 14, 2025
Suitable
planting
systems
are
critical
for
the
physicochemical
and
bioactivities
of
strawberry
(Fragaria
×
ananassa
Duch.)
polysaccharides
(SPs).
In
this
study,
SPs
were
prepared
through
hot
water
extraction,
differences
in
characteristics
between
derived
from
elevated
matrix
soilless
strawberries
(EP-SP)
those
conventional
soil
(GP-SP)
investigated.
A
higher
extraction
yield
was
observed
EP-SP
(5.88%)
than
GP-SP
(4.67%),
slightly
values
measured
average
molecular
weight
(632.10
kDa
vs.
611.88
kDa)
total
sugar
content
(39.38%
34.92%)
EP-SP.
contrast,
a
protein
(2.12%
1.65%)
more
ordered
arrangement
exhibited
by
GP-SP.
Monosaccharide
composition
analysis
revealed
that
contained
levels
rhamnose
(12.33%)
glucose
(49.29%),
whereas
richer
galactose
(11.06%)
galacturonic
acid
(19.12%).
Thermal
indicated
only
minor
decomposition
temperatures
(approximately
225-226
°C)
thermal
stability
samples.
However,
showed
enthalpy
change
(ΔHg
=
18.74
J/g)
compared
to
(13.93
J/g).
Biological
activity
assays
generally
exerted
stronger
non-enzymatic
glycation
inhibition
at
both
early
final
stages
(IC50:
7.47
mg/mL
7.82
11.18
11.87
mg/mL,
respectively),
effective
against
intermediate
α-dicarbonyl
compounds
(maximum
75.32%).
Additionally,
superior
α-glucosidase
(IC50
2.4583
mg/mL),
line
with
kinetic
fluorescence
quenching
analyses
showing
enzyme-substrate
complex
binding
affinity
(Kis
1.6682
mg/mL;
Ka
5.1352
105
M-1).
Rheological
measurements
demonstrated
solutions
pronounced
increase
apparent
viscosity
concentrations
(reaching
3477.30
mPa·s
0.1
s-1
70
mg/mL)
shear-thinning
behavior,
while
comparatively
lower
network
order.
These
findings
suggest
different
significantly
affect
structures
functionalities
SPs,
demonstrating
enhanced
hypoglycemic
anti-glycation
properties.
It
is
therefore
recommended
suitable
be
selected
optimize
functionality
plant-derived
potential
applications
food
pharmaceutical
industries.
Frontiers in Nutrition,
Год журнала:
2025,
Номер
12
Опубликована: Янв. 30, 2025
The
antioxidant
activity
of
natural
products
is
closely
related
to
their
antiglycation
effects.
This
study
aimed
examine
the
and
elucidate
underlying
mechanisms
two
specific
peptides,
EDYGA
(Glu-Asp-Tyr-Gly-Ala)
DLLCIC
(Asp-Leu-Leu-Cys-Ile-Val),
derived
from
protein
hydrolysates
Pelodiscus
sinensis
.
Both
were
efficient
in
bovine
serum
albumin
(BSA)/glucose
model
inhibit
BSA
glycation,
while
showed
higher
than
EDYGA.
Firstly,
it
was
found
that
could
formation
NEG
AGEs.
Moreover,
able
maintain
secondary
structure
stabilize
band
positions
(amide
I
&
II).
Additionally,
molecular
simulations
indicated
can
spontaneously
interact
with
central
site
BSA,
specifically
at
Lys114
Glu424
residues,
through
hydrogen
bonds
an
energy
strength
−0.7
kcal/mol.
Furthermore,
CCK-8
morphological
experiments
confirmed
improved
cell
survival
against
AGEs-induced
cytotoxicity,
EC50
values
17.64
μM
for
15.08
DLLCIC.
These
findings
serve
as
a
significant
reference
development
effective
agents
prevention
glycation-mediated
diseases.
