International Immunopharmacology, Год журнала: 2024, Номер 143, С. 113406 - 113406
Опубликована: Окт. 18, 2024
Язык: Английский
Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)
Опубликована: Май 20, 2024
Abstract Tumor biomarkers, the substances which are produced by tumors or body’s responses to during tumorigenesis and progression, have been demonstrated possess critical encouraging value in screening early diagnosis, prognosis prediction, recurrence detection, therapeutic efficacy monitoring of cancers. Over past decades, continuous progress has made exploring discovering novel, sensitive, specific, accurate tumor significantly promoted personalized medicine improved outcomes cancer patients, especially advances molecular biology technologies developed for detection biomarkers. Herein, we summarize discovery development including history conventional innovative used biomarker classification biomarkers based on tissue origins, application clinical management. In particular, highlight recent advancements biomarker-based anticancer-targeted therapies emerging as breakthroughs promising strategies. We also discuss limitations challenges that need be addressed provide insights perspectives turn into opportunities this field. Collectively, multiple emphasized review may guidance precision medicine, broaden horizons future research directions, expedite patients according their rather than organs origin.
Язык: Английский
Процитировано
134
Biomedicines, Год журнала: 2024, Номер 12(7), С. 1385 - 1385
Опубликована: Июнь 21, 2024
Circulating nucleosome levels are commonly elevated in physiological and pathological conditions. Their potential as biomarkers for diagnosing prognosticating sepsis remains uncertain due, part, to technical limitations existing detection methods. This scoping review explores the possible role of concentrations diagnosis, prognosis, therapeutic management sepsis. A comprehensive literature search Cochrane Medline libraries from 1996 1 February 2024 identified 110 potentially eligible studies, which 19 met inclusion criteria, encompassing a total 39 SIRS patients, 893 280 septic shock 117 other ICU control 345 healthy volunteers. The enzyme-linked immunosorbent assay [ELISA] was primary method measurement. Studies consistently reported significant correlations between NET biomarkers. Nucleosome were higher patients with than volunteers associated disease severity, indicated by SOFA APACHE II scores. Non-survivors had survivors. levels, therefore, show promise early markers NETosis sepsis, moderate diagnostic accuracy strong severity prognosis. However, available evidence is drawn mainly single-center, observational studies small sample sizes varied methods, warranting further investigation.
Язык: Английский
Процитировано
6
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Год журнала: 2025, Номер 1880(2), С. 189283 - 189283
Опубликована: Фев. 9, 2025
Biomarkers play a central role in diagnosing, prognosis, and therapeutic management of gliomas, diverse group malignancies arising from glial cells the brain spinal cord. Among various emerging biomarkers, gasdermin protein family has attracted attention for its involvement pyroptosis. Understanding expression function GSDM gliomas may provide new insights into tumor behavior avenues intervention. This review discusses family's significance as glioma biomarker, explores dual suppression, highlights potential utility clinical practice novel target therapy.
Язык: Английский
Процитировано
0
Current Issues in Molecular Biology, Год журнала: 2025, Номер 47(2), С. 133 - 133
Опубликована: Фев. 19, 2025
Cellular nucleosomes-the structural and functional units of chromatin-are inherently present in cells. During cellular damage or cell death, nucleosomes are released into circulation, either actively passively. Once released, can become immunogenic entities through various mechanisms. The nucleosomal proteins nucleosomes, called histones, play a pivotal role inducing immunogenicity. However, intact more than the histones alone, as double-stranded deoxyribonucleic acid (dsDNA) enhances its potential. Our recent study has shown that circulating predominantly rather free histones. Consequently, primarily function integral parts acting independently. Circulating their associated implicated pathogenesis wide array diseases. Notably, they critical lung injury sepsis. These diseases have high morbidity mortality rates lack early diagnostic biomarkers. Further investigation is required to fully elucidate disease processes. This review aims discuss current understanding sepsis, with focus on underlying
Язык: Английский
Процитировано
0
Life, Год журнала: 2024, Номер 14(10), С. 1247 - 1247
Опубликована: Окт. 1, 2024
Stroke is the third leading cause of death in developed world and a major chronic disability, especially among elderly population. The biomarkers stroke which are most promising for predicting onset time independently differentiating ischemic from hemorrhagic other subtypes at present limited to few. This review aims emphasize on prognostic role S100 calcium-binding protein b (S100B), Glial Fibrillary Acidic Protein (GFAP) patients with stroke. An electronic search published research January 2000 February 2024 was conducted using MEDLINE, Scopus, Cochrane databases. implementation S100B GFAP existing clinical scales imaging modalities may be used improve diagnostic accuracy realize potential blood practice. reviewed studies highlight as significant prognosis diagnosis their ability long-term neurological deficits. They demonstrate high sensitivity specificity between they correlate well severity outcomes. Several also early elevation these post-stroke onset, underscoring value risk stratification. ongoing this field should aim improving patient outcomes reducing stroke-related morbidity mortality by developing reliable, non-invasive tool that can easily implemented several healthcare settings, ultimate goal management.
Язык: Английский
Процитировано
1
Опубликована: Янв. 1, 2024
Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI
Язык: Английский
Процитировано
0
International Immunopharmacology, Год журнала: 2024, Номер 143, С. 113406 - 113406
Опубликована: Окт. 18, 2024
Язык: Английский
Процитировано
0