Biomedicines,
Год журнала:
2025,
Номер
13(1), С. 100 - 100
Опубликована: Янв. 3, 2025
The
gut
microbiota,
a
dynamic
ecosystem
of
trillions
microorganisms,
produces
secondary
metabolites
that
profoundly
influence
host
health.
Recent
research
has
highlighted
the
significant
role
these
metabolites,
particularly
short-chain
fatty
acids,
indoles,
and
bile
in
modulating
immune
responses,
impacting
epigenetic
mechanisms,
contributing
to
disease
processes.
In
gastrointestinal
(GI)
cancers
such
as
colorectal,
liver,
gastric
cancer,
microbial
can
drive
tumorigenesis
by
promoting
inflammation,
DNA
damage,
evasion.
Conversely,
same
hold
therapeutic
promise,
potentially
enhancing
responses
chemotherapy
immunotherapy
even
directly
suppressing
tumor
growth.
addition,
play
crucial
roles
infectious
susceptibility
resilience,
mediating
pathways
impact
pathogen
resistance.
By
consolidating
recent
insights
into
microbiota's
shaping
health,
this
review
underscores
potential
targeting
microbiome-derived
for
treating
GI
diseases
calls
further
microbiome-based
interventions.
Chemical and Biological Technologies in Agriculture,
Год журнала:
2024,
Номер
11(1)
Опубликована: Июнь 4, 2024
Abstract
Background
This
study
utilized
ultrasonication-assisted
green
extraction
techniques
to
explore
the
physicochemical,
rheological,
biological,
and
prebiotic
properties,
alongside
gut
modulation
abilities
of
novel
polysaccharides
extracted
from
date
pomace.
The
aimed
at
enhancing
utilization
pomace,
a
by-product
fruit
processing,
by
investigating
its
potential
as
functional
food
ingredient.
research
focused
on
optimizing
process,
understanding
complex
structure
polysaccharides,
assessing
their
various
health-related
functionalities.
Results
ultrasonically
(UPS)
were
identified
mixture
significant
bioactive
compounds
including
galacturonic
acid,
galactose,
glucose,
arabinose,
fructose,
showcasing
high
molecular
weight
537.7
kDa.
found
that
UPS
exhibited
outstanding
antioxidant
activities,
with
scavenging
ranging
59
82%
concentration
1000
mg/L.
Additionally,
demonstrated
potent
inhibitory
effects
α-amylase
(83%),
α-glucosidase
(81%),
ACE-inhibition
(45%),
strong
antiproliferative
activities
against
Caco-2
MCF-7
cancer
cell
lines
broad-spectrum
antimicrobial
properties.
Remarkably,
also
enhanced
abundance
beneficial
microbiota,
Actinobacteria,
Firmicutes,
Proteobacteria,
during
in
vitro
fermentations
positively
modulated
metabolic
pathways,
promoting
production
major
short-chain
fatty
acids.
had
higher
pathways
related
cofactors,
vitamins,
electron
carriers,
prosthetic
groups
biosynthesis
compared
blank.
Conclusions
findings
affirm
pomace
an
innovative
promising
Its
weight,
sugar
composition,
antioxidant,
antimicrobial,
properties
make
it
valuable
resource
for
health
managing
diseases.
paves
way
further
bioavailability
physiological
vivo,
highlighting
importance
sustainable
agricultural
by-products
developing
foods
support
human
health.
Graphical
Comprehensive Reviews in Food Science and Food Safety,
Год журнала:
2025,
Номер
24(2)
Опубликована: Март 1, 2025
Plant-derived
polysaccharides
have
emerged
as
sustainable
biopolymers
for
fabricating
nanoparticles
(polysaccharide-based
nanomaterials
[PS-NPs]),
presenting
unique
opportunities
to
enhance
food
functionality
and
human
health.
PS-NPs
exhibit
exceptional
biocompatibility,
biodegradability,
structural
versatility,
enabling
their
integration
into
functional
foods
positively
influence
gut
microbiota.
This
review
explores
the
mechanisms
of
interaction
with
microbiota,
highlighting
ability
promote
beneficial
microbial
populations,
such
Lactobacilli
Bifidobacteria,
stimulate
production
short-chain
fatty
acids.
Key
synthesis
stabilization
methods
are
discussed,
focusing
on
role
in
improving
bioavailability,
stability,
gastrointestinal
delivery
bioactive
compounds
systems.
The
potential
address
challenges
science,
including
enhancing
nutrient
absorption,
mitigating
intestinal
dysbiosis,
supporting
through
innovative
nanotechnology,
is
critically
evaluated.
Barriers
enzymatic
degradation
physicochemical
stability
analyzed,
alongside
strategies
optimize
within
complex
matrices.
systems
offers
a
novel
approach
modulate
improve
health,
drive
development
next-generation
foods.
Future
research
should
focus
bridging
knowledge
gaps
metagenomic
metabolomic
profiling
PS-NPs,
optimizing
design
diverse
applications,
advancing
health-promoting
innovations.
Antibiotics,
Год журнала:
2025,
Номер
14(4), С. 337 - 337
Опубликована: Март 24, 2025
Background:
The
emergence
of
linezolid
resistance,
mediated
by
genes
such
as
optrA
and
cfr(D),
poses
a
growing
public
health
threat.
While
these
have
been
detected
in
clinical
animal-derived
Enterococcus
species,
their
presence
underexplored
species
like
saccharolyticus
remains
undocumented,
leaving
significant
gap
our
understanding
dissemination
stability.
Method:
E.
GXN23C125Es
was
screened
for
the
known
resistance
via
PCR
analysis.
Conjugation
stability
experiments
were
used
to
evaluate
transferability
genes.
complete
genome
obtained
using
both
Illumina
Nanopore
platforms.
Results:
We
report
first
identification
cfr(D)
from
chicken
feces
China.
Whole-genome
sequencing
revealed
multiple
plasmid-borne
genes,
including
optrA,
fexA,
erm(A).
Stability
testing
demonstrated
that
highly
stable,
while
rapidly
lost
without
selective
pressure.
Conclusions:
These
findings
highlight
potential
reservoir
underscoring
need
enhanced
surveillance
determinants
animal-associated
bacteria.
Understanding
dynamics
is
crucial
mitigating
impact
on
guiding
antimicrobial
management
strategies.
