International Journal of Biological Macromolecules, Год журнала: 2024, Номер 285, С. 138328 - 138328
Опубликована: Дек. 2, 2024
Язык: Английский
Bioactive Materials, Год журнала: 2024, Номер 38, С. 95 - 108
Опубликована: Апрель 23, 2024
Androgenetic alopecia (AGA), the most prevalent clinical hair loss, lacks safe and effective treatments due to downregulated angiogenic genes insufficient vascularization in perifollicular microenvironment of bald scalp AGA patients. In this study, a hyaluronic acid (HA) based hydrogel-formed microneedle (MN) was designed, referred as V-R-MNs, which simultaneously loaded with vascular endothelial growth factor (VEGF) novel loss drug Ritlecitinib, latter is encapsulated slowly biodegradable polyhydroxyalkanoates (PHAs) nanoparticles (R-PHA NPs) for minimally invasive treatment. The integration HA hydrogel alongside PHA significantly bolstered mechanical characteristics microneedles enhanced skin penetration efficiency. Due biosafety, strength, controlled degradation properties formed microneedles, V-R-MNs can effectively penetrate skin's stratum corneum, facilitating direct delivery VEGF Ritlecitinib invasive, painless long-term sustained release manner. not only promoted angiogenesis improve immune around follicle promote proliferation development cells, but also application MNs produce certain stimulation could angiogenesis. comparison minoxidil treatment, regeneration effect V-R-MN model mice characterized by rapid onset anagen phase, improved quality, greater coverage. This introduces new, clinically safer, more efficient strategy serving reference treatment other related diseases.
Язык: Английский
Процитировано
31
Environmental Research, Год журнала: 2025, Номер unknown, С. 120904 - 120904
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
2
Advanced Healthcare Materials, Год журнала: 2024, Номер 13(29)
Опубликована: Июнь 17, 2024
Successful bone regeneration requires close cooperation between marrow mesenchymal stem cells (BMSCs) and macrophages, but the low osteogenic differentiation efficiency of excessive inflammatory response immune hinder development repair. It is necessary to develop a strategy that simultaneously regulates BMSCs anti-inflammatory polarization macrophages for accelerating regeneration. Herein, calcium-chlorogenic acid nanoparticles (Ca-CGA NPs) are synthesized by combining small molecules chlorogenic (CGA) with Ca
Язык: Английский
Процитировано
5
Deleted Journal, Год журнала: 2025, Номер unknown
Опубликована: Март 29, 2025
Abstract After more than 20 years of development, synthetic biology has emerged as an interdisciplinary field that integrates biology, medicine, mathematics, and engineering. By constructing regulating genetic elements, networks, pathways, artificially engineered bacteria, cells, or viruses can directly interact with the human body to enable disease treatment via biology. Additionally, platforms have been employed in production medical biomaterials (MBMs), indirectly contributing maintenance health. In this review, we present a range typical MBMs derived from platforms, including polylactic acid, polyhydroxyalkanoates, hyaluronic collagen, poly(β‐hydroxybutyrate), poly(β‐malic acid), poly‐γ‐glutamic alginate, chitosan, bacterial cellulose, antimicrobial peptides. We also introduce key techniques tools involved, such chassis cell design, gene expression regulation editing represented by CRISPRi, metabolic engineering, morphology cell‐free systems. Furthermore, summarize recent advancements strategies enhancing cost‐reduction, biosynthesis novel materials, material characteristics diversity, minimizing toxicity biosynthetic systems, designing living materials research applications clinical translation for MBMs. Finally, discuss emerging trends may shape future biomedical
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 282, С. 136582 - 136582
Опубликована: Окт. 22, 2024
Язык: Английский
Процитировано
3
Journal of Polymer Science, Год журнала: 2024, Номер 62(22), С. 4966 - 4992
Опубликована: Авг. 9, 2024
Abstract In recent years, the prevalence of bone diseases is showing an increasing trend, which mainly attributed to aging global population. However, repair and regeneration are still unsolved problem in treatment diseases, include a series biological events. Photocrosslinked natural hydrogel‐based microspheres (PNHMs) spherical particles composed photocrosslinked hydrogel components. Due their morphology, injectability, biocompatibility, PNHMs widely used tissue regeneration, particularly for defects. this article, we review available materials PNHMs, then introduce preparation methods. After that, summarize important advanced functionalities PNHMs. For example, can be loaded with different active ingredients exert anti‐inflammatory, antibacterial, antioxidant effects, while also realizing lubrication due specific shape size distribution. addition, function capturing ions realized via coordination. When applied engineering, promote angiogenesis osteogenesis, great potential diseases. Finally, challenges prospects discussed.
Язык: Английский
Процитировано
2
Smart Materials in Medicine, Год журнала: 2024, Номер unknown
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
0
Emergent Materials, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 19, 2024
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 285, С. 138328 - 138328
Опубликована: Дек. 2, 2024
Язык: Английский
Процитировано
0