The nanocarrier strategy for crossing the blood-brain barrier in glioma therapy

Chinese Chemical Letters, Год журнала: 2024, Номер unknown, С. 109996 - 109996

Опубликована: Май 1, 2024

Язык: Английский

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NEK2 promotes TP53 ubiquitination to enhance the proliferation and migration of TP53 wild-type glioblastoma cells

Neoplasma, Год журнала: 2024, Номер 71(03), С. 255 - 265

Опубликована: Янв. 1, 2024

The most common primary malignant tumor in the adult brain is glioblastoma multiforme (GBM); however, its underlying pathogenic mechanism remains elusive. never mitosis (NIMA)-related kinase 2 (NEK2) has been closely associated with prognosis of various malignancies. Nevertheless, complete elucidation NEK2's potential clinical value, particularly glioma and development, lacking. U87MG A172 cells were infected sh-NEK2 lentivirus or oe-NEK2 plasmid to investigate effect NEK2 on cell proliferation, migration, invasion. Cell viability was measured using CCK-8 colony formation assays, while Transwell assay utilized assess migration Protein expression levels determined through western blot analysis. Additionally, CGGA TCGA databases used for bioinformatics analysis order examine expression. Through comprehensive analysis, we identified elevated mRNA gliomas compared normal tissues, which correlated poor among patients. Moreover, functional experiments revealed that silencing suppressed proliferation overexpression promoted invasion capabilities. Finally, our study uncovered regulates progression TP53 wild-type by facilitating ubiquitination.

Язык: Английский

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Photoreceptor-targeted extracellular vesicles-mediated delivery of Cul7 siRNA for retinal degeneration therapy

Theranostics, Год журнала: 2024, Номер 14(13), С. 4916 - 4932

Опубликована: Янв. 1, 2024

Photoreceptor loss is a primary pathological feature of retinal degeneration (RD) with limited treatment strategies. RNA interference (RNAi) has emerged as promising method gene therapy in regenerative medicine. However, the transfer RNAi therapeutics to photoreceptors and deficiency effective therapeutic targets are still major challenges RD.

Язык: Английский

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Scientific investigation of non-coding RNAs in mitochondrial epigenetic and aging disorders: Current nanoengineered approaches for their therapeutic improvement

Mitochondrion, Год журнала: 2024, Номер 80, С. 101979 - 101979

Опубликована: Ноя. 5, 2024

Язык: Английский

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