Organic Communications,
Год журнала:
2024,
Номер
3, С. 133 - 143
Опубликована: Авг. 4, 2024
Ulcerative
colitis
(UC)
is
a
chronic
inflammatory
bowel
disease
mainly
affecting
the
colon
and
remains
challenging
to
manage
clinically
with
its
relapsing-remitting
course.Traditional
treatments
for
this
showed
some
drawbacks,
including
systemic
toxicity
ineffective
targeting
of
affected
areas.This
article
introduces
unique
treatment
method
that
uses
mesalazine
(MSZ)-loaded
TPP/Chitosan
nanoparticles
(MSZNP)-embedded
into
bovine
serum
albumin
(BSA)
hydrogels
(MSZNPH)
targeted
intrarectal
medication
delivery.Additionally,
conventional
MSZ
was
integrated
BSA
hydrogel
(MSZH),
then,
MSZH,
MSZNP,
MSZNPH
were
characterized
compared
an
emphasis
on
encapsulation
efficiency,
drug
release
profile,
swelling
behavior.Our
findings
show
composite
technology
may
improve
administration
prolonged
MSZ,
indicating
promising
new
route
UC
therapy
potential
patient
adherence
outcomes.
Tissue Engineering Part B Reviews,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 21, 2025
The
study
of
the
human
nervous
system
remains
challenging
due
to
its
inherent
complexity
and
difficulty
in
obtaining
original
samples.
Three-dimensional
(3D)
bioprinting
is
a
rapidly
evolving
technology
field
tissue
engineering
that
has
made
significant
contributions
several
disciplines,
including
neuroscience.
In
order
more
accurately
reflect
intricate
multicellular
milieu
vivo
environment,
an
increasing
number
studies
have
commenced
experimentation
with
coprinting
diverse
cell
types.
This
article
provides
overview
technical
details
application
3D
multiple
types
neuroscience,
focusing
on
challenges
research
conducted
based
printing.
review
discusses
interactions
systems,
stem
applications,
construction
brain-like
organoids,
establishment
disease
models,
potential
for
integrating
other
culture
techniques.
Organic Communications,
Год журнала:
2024,
Номер
3, С. 133 - 143
Опубликована: Авг. 4, 2024
Ulcerative
colitis
(UC)
is
a
chronic
inflammatory
bowel
disease
mainly
affecting
the
colon
and
remains
challenging
to
manage
clinically
with
its
relapsing-remitting
course.Traditional
treatments
for
this
showed
some
drawbacks,
including
systemic
toxicity
ineffective
targeting
of
affected
areas.This
article
introduces
unique
treatment
method
that
uses
mesalazine
(MSZ)-loaded
TPP/Chitosan
nanoparticles
(MSZNP)-embedded
into
bovine
serum
albumin
(BSA)
hydrogels
(MSZNPH)
targeted
intrarectal
medication
delivery.Additionally,
conventional
MSZ
was
integrated
BSA
hydrogel
(MSZH),
then,
MSZH,
MSZNP,
MSZNPH
were
characterized
compared
an
emphasis
on
encapsulation
efficiency,
drug
release
profile,
swelling
behavior.Our
findings
show
composite
technology
may
improve
administration
prolonged
MSZ,
indicating
promising
new
route
UC
therapy
potential
patient
adherence
outcomes.
