Excipients for Cerium Dioxide Nanoparticle Stabilization in the Perspective of Biomedical Applications

Molecules, Год журнала: 2025, Номер 30(6), С. 1210 - 1210

Опубликована: Март 8, 2025

Rare earth metal nanoparticles, some of which are already widely used in medicine, growing interest the modern scientific community. One promising rare metals for biomedical applications is cerium, specifically its oxide form, characterized by a higher level stability and safety. According to number studies, cerium dioxide has wide range biological effects (regenerative, antimicrobial, antioxidant, antitumor), justifies potential application medicine. However, these their intensity vary significantly across studies. Since was it can be assumed that not only chemical formula important, but also physicochemical parameters nanoparticles obtained, consequently methods synthesis modification with use excipients. In this review, we considered possibilities using excipients (polyacrylate, polyvinylpyrrolidone, dextran, hyaluronic acid, chitosan, polycarboxylic acids, lecithin, phosphatidylcholine) context preserving properties, as well degree study combinations from point view prospect creating drugs based on applications.

Язык: Английский

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Intraocular Injectable Hydrogels for the Delivery of Cells and Nanoparticles

Materials Today Bio, Год журнала: 2025, Номер unknown, С. 101767 - 101767

Опубликована: Апрель 1, 2025

Язык: Английский

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Innovations in ocular drug delivery

Southeast Asian Journal of Health Professional, Год журнала: 2024, Номер 7(3), С. 59 - 64

Опубликована: Окт. 4, 2024

Traditional ocular drug delivery methods via topical (eye drops and ointments) systemic routes (oral or intravenous medications) yield suboptimal therapeutic concentrations intraocularly. Innovations aimed at improving the localization, duration, efficacy of have shifted treatment paradigm by enhancing penetration, sustaining release also patient compliance. :Aim this review is to summarize recent advancements in systems, evaluate their clinical effectiveness discuss potential improve outcomes. The will identify ongoing challenges future research avenues leading further progress field. Recent systems are based on Nanotechnology-based systems; Sustained-release implants devices; Hydrogels contact lens; Microneedle technology Gene therapy vectors. Nanoparticles, nanomicelles, nanoemulsions penetration provide sustained within tissues. Biodegradable non-biodegradable devices offer prolonged delivery. drug-embedded lenses improved comfort. arrays enabling minimally invasive directly Viral non-viral vectors address underlying genetic causes inherited retinal diseases. such as eye drops, ointments, intravitreal injections limitations, including poor bioavailability, frequent administration, non-compliance. Emergence novel nanoparticles, microneedles, sustained-release implants, gene vectors, offers solutions these challenges. These innovations controlled release, stability, targeted specific tissues, resulting enhanced outcomes reduced side effects.

Язык: Английский

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Pullulan fermented by Aureobasidium melanogenum TZ-FC3 for the preparation of self-healing, adhesive, injectable and antibacterial pullulan/PVA/borax hydrogel

International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 138544 - 138544

Опубликована: Дек. 1, 2024

Язык: Английский

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