Biomolecules,
Год журнала:
2024,
Номер
14(9), С. 1129 - 1129
Опубликована: Сен. 6, 2024
Conventional
pulp
capping
materials
have
limited
anti-inflammatory
capacity.
It
is
necessary
to
develop
more
effective
material
for
the
treatment
of
inflamed
pulps.
Tannic
acid
(TA)
a
natural,
water-soluble
polyphenol
with
antimicrobial
and
properties.
This
study
aimed
investigate
effects
tannin-containing
hydroxypropyl
chitin
hydrogel
(HPCH/TA
hydrogel)
as
an
innovative
material.
The
physicochemical
properties
composite
hydrogels
were
characterized.
HPCH/TA
evaluated
in
vitro
vivo.
underlying
mechanism
was
explored.
demonstrated
favorable
temperature
sensitivity,
injectability,
antibacterial
In
vitro,
effectively
promoted
proliferation
human
dental
cells
inhibited
interleukin-1β,
interleukin-6,
tumor
necrosis
factor-α
expression,
possibly
by
suppressing
nuclear
factor
kappa-B
pathway.
vivo,
on
fourth
day
after
capping,
group
showed
lower
inflammatory
scores
compared
control
iRoot
BP
Plus
(commercial
material)
group.
By
sixth
week,
complete
reparative
dentin
formation
observed
group,
no
difference
thickness
Collectively,
holds
promise
bioactive
promoting
repair
vital
therapy.
Abstract
Background
Magnesium
ions
play
crucial
roles
in
maintaining
cellular
functions.
Research
has
shown
that
Mg2+
can
promote
angiogenesis,
indicating
its
potential
for
treating
cardiovascular
ischemic
diseases.
However,
conventional
intravenous
or
oral
administration
of
presents
several
challenges,
including
the
risk
systemic
side
effects,
diminished
bioavailability,
and
a
lack
targeted
delivery
mechanisms.
In
this
study,
we
designed
Mg2+-releasing
adhesive
tissue
patch
(MgAP)
enables
dural
release
ions.
Methods
A
novel
was
developed
on
basis
ionic
crosslinking.
Fourier
transform
infrared
spectroscopy
confirmed
chemical
structure,
whereas
rheological
analysis
demonstrated
stable
mechanical
properties
adaptability
to
dynamic
loads.
Sustained
quantified
over
7
days
by
inductively
coupled
plasma–mass
spectrometry.
rat
acute
myocardial
infarction
model,
performed
echocardiography
strain
assess
cardiac
function
histological
staining
evaluate
adverse
remodeling.
We
also
verified
proangiogenic
effect
through
vitro
tube
formation
vivo
immunofluorescence
assays.
Furthermore,
transcriptomics
Western
blotting
were
explore
underlying
mechanism.
Additional
assessments
carried
out
model
lower
limb
ischemia.
Results
Compared
with
magnesium
chloride,
MgAP
application
effectively
improved
reduced
remodeling
model.
The
left
ventricular
ejection
fraction
increased
20.3
±
6.6%,
radial
27.4
4.1%.
fibrosis
area
cell
apoptosis
rate
decreased
10.9
1.2%
32.1
5.5%,
respectively.
RNA
sequencing
highlighted
upregulation
genes
related
electrophysiological
properties,
structural
functional
intercellular
connections,
revascularization.
gap
junction
protein
expression
restored
local
blood
supply
could
contribute
repair
process
posttreatment.
observed
ischemia
Conclusions
above
results
revealed
convincing
vascular
regeneration
an
ion
therapy-based
hydrogel,
which
enabled
tissue,
aiding
repair.
This
study
strategy
highlights
use
across
various
conditions.
Journal of drug targeting,
Год журнала:
2025,
Номер
unknown, С. 1 - 24
Опубликована: Фев. 28, 2025
This
study
developed
an
alginate,
gelatin,
and
chondroitin
sulfate
hydrogel
incorporating
silicon
oxide
nanoparticles
to
assess
morphology,
cell
proliferation,
viability.
The
effectiveness
of
these
hydrogels
for
cartilage
repair
was
evaluated
in
vivo
using
male
albino
rabbits,
divided
into
three
groups:
a
control
group
without
hydrogels,
observer
with
lacking
nanoparticles,
treatment
nanoparticle-enhanced
post-injury
repair.
At
15,
30,
60
days
post-surgery,
the
rabbits
were
humanely
euthanized,
excised
tissue
samples
fixed
10%
formalin
histopathological
analysis,
then
processed
embedded
paraffin
microscopic
evaluation.
Statistical
analysis
performed
SPSS
software
ANOVA
Tukey's
post
hoc
test.
Results
indicated
that
supported
viability
encouraged
differentiation
chondrocyte-like
phenotypes.
Scanning
Electron
Microscopy
(SEM)
confirmed
hydrogels'
porosity
showed
significant
differences
survival
rates
compared
group,
underscoring
potential
engineering
regenerative
strategies.
Materials,
Год журнала:
2025,
Номер
18(5), С. 1125 - 1125
Опубликована: Март 2, 2025
We
herein
demonstrate
the
utility
of
gelatin
methacryloyl
(GelMA)/poly(ethylene
glycol)
diacrylate
(PEGDA)-cerium
oxide
(CeO2)
hydrogel
inks
for
manufacturing
scaffolds
with
antimicrobial
efficacy
by
vat
photopolymerization.
For
uniform
blending
GelMA/PEGDA
hydrogels,
CeO2
nanoparticles
a
round
shape
were
synthesized
precipitation
method
coupled
calculation
at
600
°C.
In
addition,
they
had
highly
crystalline
phases
and
desired
chemical
structures
(oxidation
states
Ce3+
Ce4+)
required
outstanding
efficacy.
A
range
GelMA/PEGDA-CeO2
different
contents
(0%
w/v,
0.1%
0.5%
1%
5%
w/v
respect
to
distilled
water
content)
manufactured.
The
photopolymerization
behavior,
mechanical
properties,
biological
properties
(swelling
biodegradation
behaviors)
characterized
optimize
content.
produced
highest
content
(5%
w/v)
showed
reasonable
(compressive
strength
=
0.56
±
0.09
MPa
compressive
modulus
0.19
0.03
MPa),
high
swelling
ratio
(1063.3
10.9%),
rate
(remaining
weight
after
28
days
39.6
2.3%).
Furthermore,
(the
number
colony-forming
units
76
44.6
(×103)).
macroporous
tightly
controlled
porous
could
be
manufactured
Bioengineering,
Год журнала:
2025,
Номер
12(3), С. 254 - 254
Опубликована: Март 3, 2025
Pancreatitis
is
a
prominent
and
severe
type
of
inflammatory
disorder
that
has
grabbed
lot
scientific
clinical
interest
to
prevent
its
onset.
It
should
be
detected
early
avoid
the
development
serious
complications,
which
occur
due
long-term
damage
pancreas.
The
accurate
measurement
biomarkers
are
released
from
pancreas
during
inflammation
essential
for
detection
treatment
patients
with
acute
chronic
pancreatitis,
but
this
sub-optimally
performed
in
clinically
relevant
practices,
mainly
complexity
procedure
cost
treatment.
Clinically
available
tests
pancreatitis
often
time-consuming.
also
relates
disorders
exocrine
pancreas,
such
as
cystic
fibrosis
hereditary
form
fibrosis-like
syndrome
acquired
genetic
symptoms
can
correlated
overexpression
specific
markers
creatinine
biological
fluids
like
urine.
In
review,
we
studied
how
develop
minimally
invasive
system
using
hydrogel-based
biosensors,
highly
absorbent
biocompatible
polymers
respond
stimuli
enzymes,
pH,
temperature,
or
presence
biomarkers.
These
biosensors
helpful
real-time
health
monitoring
medical
diagnostics
since
they
translate
reactions
into
quantifiable
data.
This
paper
sheds
light
on
possible
use
Ayurvedic
formulations
along
hydrogels
strategy.
analytical
devices
used
enhance
real
time.
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 14, 2025
The
prevalence
of
heart
valve
disease
(HVD)
has
escalated
worldwide,
because
population
aging.
Currently,
artificial
replacement
is
considered
the
most
effective
treatment
for
HVD.
complexity
and
risk
have
been
markedly
reduced
with
development
minimally
invasive
interventional
techniques,
which
resulted
in
more
widespread
implantation
bioprosthetic
valves
(BHVs);
however,
they
still
present
defects
including
thrombosis,
poor
cytocompatibility,
immune
responses,
calcification,
reduces
their
service
life.
We
developed
a
microenvironment-responsive
zwitterionic
glycocalyx-mimetic
hydrogel-engineered
BHV
(Hes@HS-PP)
profile
on-demand
drug
release.
Inspired
by
structure
function
glycocalyx
on
inner
wall
blood
vessels,
hydrogel
coating
was
covalently
constructed
photoinduced
polymerization.
This
significantly
resisted
fouling
components
thrombosis
improved
endothelialization
potential
biocompatibility
BHVs
shielding
interactions
between
xenogeneic
collagenous
matrix.
Following
introduction
dynamic
borate
ester
bonds
into
hydrogel,
anti-inflammatory
hesperidin
(Hes)
loaded
onto
BHVs.
Excess
reactive
oxygen
species
were
scavenged,
Hes
released
inflammatory
region
demand
to
achieve
regulation
ameliorate
reactions
Moreover,
Hes@HS-PP
exhibited
lower
degree
calcification
rat
subcutaneous
model.
In
summary,
construction
hydrogels
enhanced
antithrombotic,
anti-inflammatory,
endothelialization,
anticalcification
properties
mitigated
structural
valvular
degradation,
offering
new
perspectives
functional
modification
Biomolecules,
Год журнала:
2024,
Номер
14(7), С. 858 - 858
Опубликована: Июль 17, 2024
Osteoarthritis
(OA),
a
chronic
joint
disease
affecting
over
500
million
individuals
globally,
is
characterized
by
the
destruction
of
articular
cartilage
and
inflammation.
Conventional
treatments
are
insufficient
for
repairing
damaged
tissue,
necessitating
novel
therapeutic
approaches.
Mesenchymal
stem
cells
(MSCs),
with
their
potential
differentiation
self-renewal,
hold
great
promise
as
treatment
OA.
However,
challenges
such
MSC
viability
apoptosis
in
ischemic
environment
hinder
effectiveness.
Hydrogels
biocompatibility
degradability
offer
three-dimensional
scaffold
that
support
cell
differentiation,
making
them
ideal
delivery
OA
treatment.
This
review
discusses
pathological
features
OA,
properties
MSCs,
associated
therapy,
methods
hydrogel
preparation
functionalization.
Furthermore,
it
highlights
advantages
hydrogel-based
systems
while
providing
insights
into
future
research
directions
clinical
this
approach.
