Polysaccharides from maggot extracts suppress colorectal cancer progression by inducing ferroptosis via HMOX1/GPX4 signaling pathway

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 139734 - 139734

Опубликована: Янв. 1, 2025

Язык: Английский

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Effects of traditional Chinese medicine polysaccharides on chronic diseases by modulating gut microbiota: A review

International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 136691 - 136691

Опубликована: Окт. 1, 2024

Язык: Английский

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Microplastics Impair Black Soldier Fly Bioconversion of Pigeon Manure: Physiological and Transcriptomic Insights

Опубликована: Янв. 1, 2025

Язык: Английский

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Bioinspired Claw‐Engaged Adhesive Microparticles Armed with γGC Alleviate Ulcerative Colitis via Targeted Suppression of Macrophage Ferroptosis

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Апрель 29, 2025

Abstract Ulcerative colitis (UC) is a chronic inflammatory bowel disease, characterized by focal iron overload. Herein, we reported that γ‐glutamylcysteine (γGC) deletion in UC lesions intensified the disease depleting intracellular GSH to induce macrophage ferroptosis, leading M1 reprogramming and eventually exacerbating inflammation. To counteract this, advanced microparticles (MPs)‐based delivery system selected encapsulate γGC. The resulting γGC‐MPs displayed same porous spiky morphology as their substrate's natural pollens, improved intestinal adhesion enhanced lesion contact of γGC‐MPs. Our results demonstrated exogenous γGC supplementation could inhibit polarization restraining well suppressing PI3K/AKT pathway TNF signaling pathway. Compared with free γGC, significantly alleviated typical symptoms dextran sulfate sodium (DSS)‐induced colitis, evidenced reduced inflammation, restored barrier function, microbiota composition. Consequently, this study addressed critical gaps understanding causes ferroptosis its impact on UC, offering novel synergistic therapeutic strategy for UC.

Язык: Английский

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Comprehensive insights of pretreatment strategies on the structures and bioactivities variation of lignin-carbohydrate complexes

Frontiers in Bioengineering and Biotechnology, Год журнала: 2024, Номер 12

Опубликована: Авг. 20, 2024

Introduction: Due to its unique structural features and bioactivities, the lignin-carbohydrate complex (LCC) displays great potential in vast industrial applications. However, elucidation of how various pretreatment methods affect structure bioactivities remains unaddressed. Method: The three were systematically studied on variations structures Gramineae plant, i.e., wheat straw, was adopted this study. variation caused by different pretreatments detail. Result Discussion: results showed that compared physical or chemical pretreatments, biological most effective approach improving LCC. LCC from (enzymatic hydrolysis, ELCC4) had more functional groups while lower weight-average molecular weight ( Mw ) polydispersity index (PDI) well-endowed. highest antioxidant abilities against ABTS DPPH ELCC4 high up 95% 84%, respectively. Furthermore, also best ultraviolet (UV)-blocking rate 96%, which increased 6% 2% LCC8 (physical pretreatment) LLCC4 (chemical pretreatment). This work prospectively boosts understanding strategies facilitates utilization as sustainable biologically active materials fields.

Язык: Английский

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Systematic preparation of animal-derived glycosaminoglycans: Research progress and industrial significance

Food Chemistry, Год журнала: 2024, Номер 464, С. 141565 - 141565

Опубликована: Окт. 9, 2024

Язык: Английский

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