Recent advances in polysaccharide-based drug delivery systems for cancer therapy: a comprehensive review
Artificial Cells Nanomedicine and Biotechnology,
Год журнала:
2024,
Номер
52(1), С. 564 - 586
Опубликована: Дек. 5, 2024
Cancer
has
a
high
rate
of
incidence
and
mortality
throughout
the
world.
Although
several
conventional
approaches
have
been
developed
for
treatment
cancer,
such
as
surgery,
chemotherapy,
radiotherapy
thermal
therapy,
they
remarkable
disadvantages
which
result
in
inefficient
cancer.
For
example,
immunogenicity,
prolonged
treatment,
non-specificity,
metastasis
cost
are
considered
major
drawbacks
chemotherapy.
Therefore,
there
is
fundamental
requirement
development
breakthrough
technologies
cancer
suppression.
Polysaccharide-based
drug
delivery
systems
(DDSs)
most
reliable
carriers
therapy.
Polysaccharides,
kind
practical
biomaterials,
divided
into
types,
including
chitosan,
alginates,
dextran,
hyaluronic
acid,
cyclodextrin,
pectin,
etc.
Polysaccharides
extracted
from
different
natural
resources
(like
herbal,
marine,
microorganisms,
etc.).
The
potential
features
polysaccharides
made
them
candidates
therapeutics
to
sites;
simple
purification,
ease
modification
functionalization,
hydrophilicity,
serum
stability,
appropriate
loading
capacity,
biocompatibility,
bioavailability,
biodegradability
stimuli-responsive
sustained
release
manner
considerable
aspects
these
biopolymers.
This
review
highlights
applications
polysaccharides-based
DDSs
pharmaceutical
science
Язык: Английский
Immunologically active cell wall polysaccharides of green microalga Dictyosphaerium chlorelloides (Chlorellacea)
Carbohydrate Polymers,
Год журнала:
2025,
Номер
353, С. 123242 - 123242
Опубликована: Янв. 9, 2025
Язык: Английский
Polysaccharide Fraction Isolated from Saccharina japonica Exhibits Anti-Cancer Effects Through Immunostimulating Activities
Marine Drugs,
Год журнала:
2025,
Номер
23(1), С. 38 - 38
Опубликована: Янв. 13, 2025
The
present
research
aimed
to
assess
the
anti-cancer
effects
of
polysaccharide
fraction
(SJP)
isolated
from
Saccharina
japonica.
release
immune-activating
cytokines,
including
IL-6,
IL-12,
and
TNF-α,
was
markedly
stimulated
by
SJP
in
a
concentration-dependent
manner
within
range
1
100
µg/mL.
Furthermore,
prophylactic
intravenous
(p.i.v.)
per
os
(p.p.o.)
injection
boosted
cytolytic
activity
mediated
NK
cells
CTLs
against
tumor
cells.
In
study
involving
Colon26-M3.1
carcinoma
as
lung
cancer
model,
both
p.i.v.
p.p.o.
exhibited
significant
anti-lung-cancer
effects.
Notably,
administration
at
dose
50
mg/kg
reduced
colonies
84%
40%,
respectively,
compared
control.
Moreover,
remained
substantial,
even
when
cell
function
inhibited
using
anti-asialo-GM1.
Fractionation
with
CaCl2
suggested
that
is
mixture
alginate
fucoidan.
fucoidan
immune
response
macrophages
more
strongly
than
fraction.
Consequently,
this
finding
S.
japonica
possesses
remarkable
through
activation
various
immunocytes.
addition,
indicates
potent
biological
may
be
attributed
Язык: Английский
Polysaccharide fraction isolated from Korean Saccharina japonica alleviates impaired immune responses in macrophages and immunosuppressed mice
Journal of Functional Foods,
Год журнала:
2025,
Номер
127, С. 106733 - 106733
Опубликована: Март 18, 2025
Язык: Английский
Ginsenosides Modulate Immunity via TLR4/MyD88/NF-κB Pathway and Gut Microbiota
Phytomedicine,
Год журнала:
2025,
Номер
142, С. 156763 - 156763
Опубликована: Апрель 12, 2025
Язык: Английский
Structure and Activity of β-Oligosaccharides Obtained from Lentinus edodes (Shiitake)
Separations,
Год журнала:
2024,
Номер
11(11), С. 326 - 326
Опубликована: Ноя. 14, 2024
The
structure
and
characteristics
of
LEOPs,
β-oligosaccharides
from
the
fruiting
body
Lentinus
edodes
obtained
via
acid
degradation
gel
permeation
chromatography,
were
investigated.
We
performed
high-performance
liquid
infrared
spectroscopy,
methylation
analysis,
nuclear
magnetic
resonance,
correlated
activity
experiments,
including
antioxidant,
immunomodulatory,
liver
injury
protection
to
gain
insights.
LEOPs
comprised
an
oligosaccharide
(Mw
2445
Da)
based
on
six
β-1,
3-D-glucose
residues
as
main
chain
6-D-glucose
side
chain.
Surface
plasmon
resonance
analysis
indicated
that
directly
bound
dectin-1,
which
facilitated
their
immunoenhancing
downstream
NF-κB
activation.
results
implied
may
be
active
unit
shiitake
β-glucan.
determination
was
reveal
anti-tumor
effect
immune-regulatory
function
β-glucan
a
molecular
level
provide
basis.
Язык: Английский