A bibliometric analysis of hydrogel research in various fields: the trends and evolution of hydrogel application
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Янв. 31, 2025
Hydrogel,
a
polymer
material
with
three-dimensional
structure,
has
considerably
expanded
in
research
across
multiple
fields
lately.
However,
the
lack
of
comprehensive
review
integrating
status
hydrogel
diverse
hindered
development
hydrogel.
This
bibliometric
analysis
reviewed
hydrogel-related
over
past
decades,
emphasizing
evolution,
status,
and
future
directions
within
multitude
fields,
such
as
materials
science,
chemistry,
engineering,
physics,
biochemistry
molecular
biology,
pharmacology
pharmacy,
cell
biotechnology
applied
microbiology,
etc.
We
encapsulated
applications
potential
wound
healing,
drug
delivery,
encapsulation,
bioprinting,
tissue
electronic
products,
environment
applications,
disease
treatment.
study
integrated
current
matrix
system
characteristics
hydrogels,
aiming
to
offer
cross-field
reference
for
researchers
promote
advancement
research.
Furthermore,
we
proposed
novel
reproducible
paradigm,
which
can
provide
more
trends
trajectory
field.
Язык: Английский
Pre-treated Mesenchymal Stem Cell-Derived Exosomes: A New Perspective for Accelerating Spinal Cord Injury Repair
European Journal of Pharmacology,
Год журнала:
2025,
Номер
992, С. 177349 - 177349
Опубликована: Фев. 5, 2025
Spinal
cord
injury
(SCI)
is
a
devastating
event
for
the
central
nervous
system
(CNS),
often
resulting
in
loss
of
sensory
and
motor
functions.
It
profoundly
affects
both
physiological
psychological
well-being
patients,
reducing
their
quality
life
while
also
imposing
significant
economic
pressure
on
families
healthcare
system.
Due
to
complex
pathophysiology
SCI,
effective
treatments
promoting
recovery
remain
scarce.
Mesenchymal
stem
cell-derived
exosomes
(MSC-Exos)
offer
advantages
such
as
low
immunogenicity,
good
biocompatibility,
ability
cross
blood-spinal
barrier
(BSCB).
In
preclinical
studies,
they
have
progressively
shown
efficacy
SCI
repair
functional
recovery.
However,
yield
insufficient
targeting
MSC-Exos
limit
therapeutic
efficacy.
Currently,
genetic
engineering
other
preprocessing
techniques
are
being
employed
optimize
properties
exosomes,
thereby
enhancing
potential.
Therefore,
this
paper
provides
an
overview
biogenesis
exosomes.
summarizes
current
approaches
optimizing
exosome
performance.
Additionally,
it
details
mechanisms
through
which
optimized
provide
neuroprotection
explores
potential
combined
involving
hydrogels.
Язык: Английский
Novel Tissue Engineering Scaffolds in the Treatment of Spinal Cord Injury—A Bibliometric Study
Bioengineering,
Год журнала:
2025,
Номер
12(4), С. 347 - 347
Опубликована: Март 28, 2025
Objective:
Because
of
the
evolving
nature
tissue
engineering
scaffolds
in
treatment
spinal
cord
injury
(SCI),
current
study
was
carried
out
to
evaluate
research
productivity
SCI.
Methods:
Studies
published
from
2000
2025
were
retrieved
Web
Science
core
collection
with
topics
and
scaffolds.
The
data
analyzed
visualized
using
VOSviewer
network
analysis
software.
Results:
Among
1542
articles
analyzed,
annual
publications
surged
2019,
stabilizing
thereafter.
U.S.,
China,
Canada
led
productivity,
Northwestern
University
Biomaterials
journal
being
top
contributors.
Keyword
revealed
hotspots
such
as
functional
recovery,
axonal
regeneration,
stem
cells,
hydrogels.
Notably,
hydrogels
embedded
genetically
engineered
cells
emerged
a
pivotal
trend,
reflecting
shift
toward
biomimetic
combinatorial
therapies.
Collaboration
networks
highlighted
intensified
partnerships
between
Chinese
North
American
institutions,
signaling
global
interdisciplinary
efforts.
Conclusions:
This
provides
first
bibliometric
roadmap
for
SCI,
identifying
key
trends,
influential
entities,
underexplored
areas.
rise
international
collaborations
underscores
opportunities
targeted
research.
These
findings
guide
researchers
prioritizing
high-impact
journals,
fostering
partnerships,
advancing
novel
scaffold
designs
bridge
translational
gaps
SCI
treatment.
Язык: Английский
Research Progress of Flavonoids in Spinal Cord Injury: Therapeutic Mechanisms and Drug Delivery Strategies
Phytotherapy Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 2, 2025
Spinal
cord
injury
(SCI)
is
a
serious
neurological
disease
with
an
extremely
high
disability
rate.
Most
patients
show
loss
of
motor
and
sensory
functions
below
the
level
injury.
Current
treatment
protocols
are
based
on
early
surgical
decompression
pharmacotherapy.
However,
efficacy
these
interventions
suboptimal.
Due
to
its
complex
pathophysiological
mechanisms
difficulty
central
nervous
system
(CNS)
regeneration,
exploring
effective
therapeutic
remains
daunting.
Flavonoids
secondary
metabolites
unique
plants
that
have
attracted
attention
in
recent
years
for
their
potential
now
commonly
used
inflammation,
tumors,
other
diseases.
For
SCI,
related
studies
still
exploring;
some
compounds,
such
as
quercetin,
fisetin,
hesperetin,
shown
good
anti-inflammatory
anti-apoptotic
properties,
which
help
restore
function
injured
spinal
cord.
flavonoids
exhibit
certain
disadvantages,
including
poor
solubility,
low
bioavailability,
inability
achieve
long-term
controlled
release.
Some
proposed
drug
delivery
strategies-including
nanoparticles,
hydrogels,
collagen
scaffolds-to
enhance
efficacy.
In
this
paper,
we
summarize
strategies
SCI
by
searching
relevant
literature
propose
future
research
directions
provide
new
ideas
multimodal
SCI.
Язык: Английский
Cation-π interaction mediated, anti-swelling, high-toughness and conductive hydrogel for regulation of PC12 neurite outgrowth
European Polymer Journal,
Год журнала:
2025,
Номер
unknown, С. 113928 - 113928
Опубликована: Апрель 1, 2025
Язык: Английский
Environment-tolerant, inherently conductive and self-adhesive gelatin-based supramolecular eutectogel for flexible sensor
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
282, С. 137219 - 137219
Опубликована: Ноя. 2, 2024
Язык: Английский
Biomimetic 3D Hydrogels with Aligned Topography for Neural Tissue Engineering
Polymers,
Год журнала:
2024,
Номер
16(24), С. 3556 - 3556
Опубликована: Дек. 20, 2024
Spinal
cord
trauma
leads
to
the
destruction
of
highly
organized
cytoarchitecture
that
carries
information
along
axis
spinal
column.
Currently,
there
are
no
clinically
accepted
strategies
can
help
regenerate
severed
axons
after
injury
(SCI).
Hydrogels
soft
biomaterials
with
high
water
content
widely
used
as
scaffolds
interface
central
nervous
system
(CNS).
Here,
we
examine
a
simple
and
reproducible
method
results
in
consistently
aligned
fibrils
within
3D
matrices
using
thermally
gelling
biomimetic
polymers.
A
collagen
type
I
(Col)-based
hydrogel
was
combination
two
other
native
extracellular
matrix
proteins:
laminin
(LN)
hyaluronic
acid
(HA).
Gelling
kinetics
for
all
gel
types
(Col,
Col
LN,
HA)
showed
at
37
°C,
three
hydrogels
formed
gels
consistently.
aspiration
ejection
produce
Col-based
containing
fibrils.
In
vitro,
embryonic
neurons
survived
produced
processes
Next,
implanted
either
non-aligned
or
bilateral
dorsal
hemisection
thoracic
T7/T8.
Pan
neuronal
antibody-positive
were
found
implants;
supported
neurite
growth
parallel
direction
hydrogels.
Combined,
our
vitro
vivo
data
indicate
through
ejection,
this
presents
novel
platform
regenerative
therapies
CNS.
Язык: Английский