Gelatin/PLA-loaded gold nanocomposites synthesis using Syzygium cumini fruit extract and their antioxidant, antibacterial, anti-inflammatory, antidiabetic and anti-Alzheimer’s activities
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Янв. 15, 2025
Nanotechnology
has
experienced
significant
advancements,
attracting
considerable
attention
in
various
biomedical
applications.
This
innovative
study
synthesizes
and
characterizes
Ge/PLA/AuNCs
(gelatin/PLA/gold
nanocomposites)
using
Syzygium
cumini
extract
to
evaluate
their
The
UV–Visible
spectroscopy
results
an
absorption
peak
at
534
nm
were
primarily
confirmed
by
synthesis.
FTIR
spectrum
showed
functional
groups
the
XRD
patterns
crystalline
shape
structure
of
nanocomposites.
FESEM
HRTEM
a
oval
with
average
particle
size
21
nm.
Ge/PLA/AuNC's
remarkable
antioxidant
activity,
as
evidenced
DPPH
(70.84
±
1.64%),
ABTS
activity
(86.17
1.96%),
reducing
power
(78.42
1.48%)
concentration
100
μg/mL
was
observed.
zone
inhibition
against
Staphylococcus
aureus
(19.45
0.89
mm)
Echericia
coli
(20.83
0.97
revealed
excellent
antibacterial
Ge/PLA/AuNCs.
anti-diabetic
supported
α-amylase
(82.56
1.49%)
α-glucosidase
(80.27
1.57%).
anti-Alzheimer
AChE
(76.37
1.18%)
BChE
(85.94
1.38%)
enzymes.
In
vivo
studies
zebrafish
embryos
that
have
biocompatibility
nontoxicity.
SH-SY5Y
cell
line
demonstrated
improved
viability
(95.27
1.62%)
enhanced
neuronal
growth
following
treatment.
conclusion,
present
highlights
cost-effective
non-toxic
properties
Furthermore,
it
presents
attractive
promising
approach
for
future
Язык: Английский
Electrosprayed core–shell microspheres co-deliver fibronectin and resveratrol for combined treatment of acute lung injury
Journal of Colloid and Interface Science,
Год журнала:
2025,
Номер
686, С. 498 - 508
Опубликована: Янв. 31, 2025
Язык: Английский
Enhancing Wound Healing with Nanohydrogel-Entrapped Plant Extracts and Nanosilver: An In Vitro Investigation
Molecules,
Год журнала:
2024,
Номер
29(21), С. 5004 - 5004
Опубликована: Окт. 22, 2024
Wound
healing
is
a
complex
process
that
can
be
improved
through
advanced
biomedical
approaches.
Incorporating
nanopolymers
and
plant
extracts
into
wound
dressings
offers
favorable
strategy
for
promoting
tissue
repair.
Nanopolymers
provide
controlled
environment
sustained
drug
release
while
also
protecting
the
from
external
contaminants.
When
combined
with
bioactive
compounds
extracts,
which
possess
antioxidant,
anti-inflammatory,
antimicrobial
properties,
this
hybrid
approach
accelerate
healing,
reduce
infection,
improve
regeneration.
Hence,
in
study,
we
have
synthesized
alginate/gelatin
hydrogel
blended
only
nanosilver
(Alg/gel-Ag)
like
aloe
vera,
curcumin,
plantain
peel
extract,
Язык: Английский
Degradation of pathogenic amyloids induced by matrix metalloproteinase-9
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
281, С. 136362 - 136362
Опубликована: Окт. 11, 2024
Язык: Английский
Marine-derived polysaccharides: the potential agents against neurodegenerative diseases
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 18, 2024
Neurodegenerative
diseases
are
primarily
characterized
by
the
selective
loss
of
neurons
in
brain,
leading
to
a
significant
and
widespread
global
public
health
burden.
Although
numerous
mechanisms
underlying
neurodegenerative
have
been
elucidated,
effective
therapeutic
strategies
still
being
explored.
Several
drugs
proposed
halt
disease
progression;
however,
they
often
come
with
severe
side
effects.
Recently,
polysaccharides
garnered
considerable
attention
due
their
antioxidant,
anti-neuroinflammatory,
anticholinesterase,
anti-amyloidogenic
properties.
The
ocean
contains
large
number
animals,
plants,
algae
fungal
species.
Its
rich
sources
wide
availability
make
research
on
marine
become
hot
topic.
dominated
fucoidan
chitosan
reported
inhibit
progression
variety
ways.
In
this
review
article,
we
provide
comprehensive
summary
that
intervene
aim
exploring
potential
as
agents.
Язык: Английский