Trinitroglycerine-loaded chitosan nanoparticles attenuate renal ischemia-reperfusion injury by modulating oxidative stress DOI Creative Commons
Zeinab Karimi,

Khatereh Asadi,

Pooran Ghahramani

и другие.

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Дек. 30, 2024

Renal ischemia-reperfusion (I/R) injury is a common clinical factor for acute kidney (AKI). A current study investigated the renoprotective effects of trinitroglycerine (TNG) combination with chitosan nanoparticles (CNPs) on renal I/R-induced AKI. Rats were randomly assigned to five groups (n = 8/group): Sham, I/R, TNG (50 mg/kg) + CNPs (60 and TNG-CNPs I/R. Bilateral pedicles occluded 60 min induce ischemia. TNG, CNPs, or administered intraperitoneally 30 before After 24 h reperfusion, blood samples collected, both kidneys removed. The left was used oxidative stress analysis. right preserved in 10% formalin histopathological examination via H&E staining. injury, there an observed increase plasma creatinine (Cr) urea nitrogen (BUN), accompanied by decrease glomerular filtration rate (GFR) rats. Total (TOS) levels also significantly higher I/R group, whereas total antioxidative capacity (TAC) reduced. Histopathological revealed damage rats group. Pretreatment TNG-CNP formulation increased tissue TAC It corrected changes functional disorders induced as evidenced reduced Cr BUN, GFR, attenuated stress. results suggest that provides against AKI improving antioxidant status minimizing injury.

Язык: Английский

Nanogels—Innovative Drug Carriers for Overcoming Biological Membranes DOI Creative Commons
Lyubomira Radeva, Krassimira Yoncheva

Gels, Год журнала: 2025, Номер 11(2), С. 124 - 124

Опубликована: Фев. 8, 2025

Nanogels are promising drug delivery systems since they possess undeniable advantages such as high loading capacity for hydrophilic and hydrophobic drugs, stabilization of sensitive biocompatibility, biodegradability. The present review summarizes experimental studies related to carriers, loading, membrane transport nanogels. In particular, the discusses properties, advantages, limitations polymeric carriers with respect behavior prepared nanogels in vivo conditions. potential nanogel encapsulation or drugs mechanisms release also emphasized. Moreover, challenges through barriers presented parenteral, oral, ocular, nasal, dermal routes administration considered.

Язык: Английский

Процитировано

0
Development of a doxepin-loaded chitosan nanogel as an innovative nano platform for oral mucositis treatment DOI
Nazafarin Samiraninezhad, Khatereh Asadi, Reza Heidari

и другие.

Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер unknown, С. 106430 - 106430

Опубликована: Ноя. 1, 2024

Язык: Английский

Процитировано

0
Trinitroglycerine-loaded chitosan nanoparticles attenuate renal ischemia-reperfusion injury by modulating oxidative stress DOI Creative Commons
Zeinab Karimi,

Khatereh Asadi,

Pooran Ghahramani

и другие.

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Дек. 30, 2024

Renal ischemia-reperfusion (I/R) injury is a common clinical factor for acute kidney (AKI). A current study investigated the renoprotective effects of trinitroglycerine (TNG) combination with chitosan nanoparticles (CNPs) on renal I/R-induced AKI. Rats were randomly assigned to five groups (n = 8/group): Sham, I/R, TNG (50 mg/kg) + CNPs (60 and TNG-CNPs I/R. Bilateral pedicles occluded 60 min induce ischemia. TNG, CNPs, or administered intraperitoneally 30 before After 24 h reperfusion, blood samples collected, both kidneys removed. The left was used oxidative stress analysis. right preserved in 10% formalin histopathological examination via H&E staining. injury, there an observed increase plasma creatinine (Cr) urea nitrogen (BUN), accompanied by decrease glomerular filtration rate (GFR) rats. Total (TOS) levels also significantly higher I/R group, whereas total antioxidative capacity (TAC) reduced. Histopathological revealed damage rats group. Pretreatment TNG-CNP formulation increased tissue TAC It corrected changes functional disorders induced as evidenced reduced Cr BUN, GFR, attenuated stress. results suggest that provides against AKI improving antioxidant status minimizing injury.

Язык: Английский

Процитировано

0