Hemoglobin‐Mediated Dual‐Crosslinked Silk Fibroin With Enhanced Elasticity, Rigidity, Toughness, and Shapeability for Tracheal Tissue Application DOI

Zhiyi Guo,

Xiang Fei, Bin Zhou

и другие.

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 14, 2025

Abstract The study presents an elastic, rigid, and shapeable silk fibroin (SF)‐based scaffold with a dual‐crosslinked network for tracheal tissue engineering. Hemoglobin (Hb), biocompatible cost‐effective natural protein, is introduced as both catalyst crosslinker. in situ chemical crosslinking occurred via dityrosine reaction the presence of hydrogen peroxide. Subsequently, freeze‐drying induced formation β‐sheet crystals, further physically SF chains, resulting 3D porous Hb‐SF scaffold. Additionally, α‐helix subunits Hb acted “molecular springs”, enhancing scaffold's mechanical strength, elasticity, toughness. biomechanical properties are tunable by adjusting content, enabling precise shape fidelity, self‐recovery, durability. Notably, exhibited high fatigue resistance, enduring multiple compressive cycles without damage. In vitro tests confirmed its cytocompatibility potential cartilage regeneration. Furthermore, vivo implantation chondrocyte‐seeded scaffolds resulted biomimetic trachea structural closely resembling those native trachea. This Hb‐mediated, demonstrates enhanced rigidity, toughness, shapeability, presenting viable option regeneration applications.

Язык: Английский

Recent advances of hyaluronic acid‐based materials in drug delivery systems and regenerative medicine: A review DOI

Mohamed J. Saadh,

Hanan Hassan Ahmed,

Radhwan Abdul Kareem

и другие.

Archiv der Pharmazie, Год журнала: 2025, Номер 358(3)

Опубликована: Март 1, 2025

Abstract Nowadays, diseases have a high rate of incidence and mortality worldwide. On the other side, drawbacks conventional modalities in suppression encountered serious problematic issues for health human beings. For instance, although various approaches been applied treatment cancer, it has an ever‐increasing throughout globe. Thus, there is fundamental requirement development breakthrough technologies inhibition diseases. Hyaluronic acid (HA) one most practical biopolymers HA lots potential physicochemical (like rheological, structural, molecular weight, ionization, etc.) biomedical properties (bioavailability, biocompatibility, CD44 targeting signaling pathways, components biological organs, mucoadhesion, immunomodulation, etc.), which made candidate tools pharmaceutical sciences. The ease surface modification (carboxylation, amidation, hydroxylation, esterification), bioavailability synthesis routes, administration routes are considered as merits HA‐based vehicles. These mucopolysaccharide materials considerably developed use drug delivery systems (DDSs), cancer therapy, wound healing, antiaging, tissue engineering. This review summarizes advantages DDS scaffolds

Язык: Английский

Процитировано

0
Esterase-Responsive Kartogenin Composite Hydrogel Microspheres Boost Nucleus Pulposus Regeneration in Intervertebral Disc Degeneration DOI
Junqi Dai, Li Ni, Chenyang Jin

и другие.

Acta Biomaterialia, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Bioengineered tracheal graft with enhanced vascularization and mechanical stability for functional airway reconstruction DOI

Yu Liang,

Shixiong Wei,

Anling Zhang

и другие.

Regenerative Therapy, Год журнала: 2025, Номер 29, С. 364 - 380

Опубликована: Апрель 9, 2025

Язык: Английский

Процитировано

0
Hemoglobin‐Mediated Dual‐Crosslinked Silk Fibroin With Enhanced Elasticity, Rigidity, Toughness, and Shapeability for Tracheal Tissue Application DOI

Zhiyi Guo,

Xiang Fei, Bin Zhou

и другие.

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 14, 2025

Abstract The study presents an elastic, rigid, and shapeable silk fibroin (SF)‐based scaffold with a dual‐crosslinked network for tracheal tissue engineering. Hemoglobin (Hb), biocompatible cost‐effective natural protein, is introduced as both catalyst crosslinker. in situ chemical crosslinking occurred via dityrosine reaction the presence of hydrogen peroxide. Subsequently, freeze‐drying induced formation β‐sheet crystals, further physically SF chains, resulting 3D porous Hb‐SF scaffold. Additionally, α‐helix subunits Hb acted “molecular springs”, enhancing scaffold's mechanical strength, elasticity, toughness. biomechanical properties are tunable by adjusting content, enabling precise shape fidelity, self‐recovery, durability. Notably, exhibited high fatigue resistance, enduring multiple compressive cycles without damage. In vitro tests confirmed its cytocompatibility potential cartilage regeneration. Furthermore, vivo implantation chondrocyte‐seeded scaffolds resulted biomimetic trachea structural closely resembling those native trachea. This Hb‐mediated, demonstrates enhanced rigidity, toughness, shapeability, presenting viable option regeneration applications.

Язык: Английский

Процитировано

0