A Review of the Development of Biopolymer Hydrogel-Based Scaffold Materials for Drug Delivery and Tissue Engineering Applications

Gels, Год журнала: 2025, Номер 11(3), С. 178 - 178

Опубликована: Март 1, 2025

Biopolymer hydrogel-based scaffold materials have received a lot of interest in tissue engineering and regenerative medicine because their unique characteristics, which include biocompatibility, biodegradability, the ability to replicate natural extracellular matrix (ECM). These hydrogels are three-dimensional biopolymer networks that highly hydrated provide supportive, wet environment conducive cell growth, migration, differentiation. They especially useful applications involving wound healing, cartilage, bone, soft regeneration. Natural biopolymers such as collagen, chitosan, hyaluronic acid, alginate frequently employed foundation for hydrogel fabrication, providing benefits low toxicity improved adherence. Despite potential, scaffolds various difficulties prevent broad clinical implementation. Key challenge balancing mechanical strength flexibility meet needs tissues, managing degradation rates line up with regeneration, assuring large-scale manufacturing while retaining uniformity quality. Furthermore, fostering appropriate vascularization infiltration larger tissues remains significant optimal integration function. Future developments likely concentrate on addressing these obstacles. Strategies creation hybrid combine synthetic materials, smart stimulus-responsive features, 3D bioprinting technologies accurate production show potential. integrating bioactive compounds growth factors into matrices promote regeneration is critical enhancing therapeutic results.

Язык: Английский

Mussel-Inspired Hydrogel Applied to Wound Healing: A Review and Future Prospects

Biomimetics, Год журнала: 2025, Номер 10(4), С. 206 - 206

Опубликована: Март 26, 2025

The application background of mussel-inspired materials is based on the unique underwater adhesive ability marine mussels, which has inspired researchers to develop bionic with strong adhesion, self-healing ability, biocompatibility, and environmental friendliness. Specifically, 3, 4-dihydroxyphenylalanine (DOPA) in mussel byssus able form non-covalent forces a variety surfaces, are critical for mussel’s adhesion enable material dissipate energy repair itself under external forces. Mussel-inspired hydrogels ideal medical due their physical chemical properties, such as excellent tissue hemostasis bacteriostasis, biosafety, plasticity. This paper reviewed chitosan, cellulose, hyaluronic acid, gelatin, alginate, other biomedical discussed advanced functions wound dressings, including antibacterial, anti-inflammatory, antioxidant hemostasis, transport, self-healing, stimulating response, so on. At same time, technical challenges limitations biomimetic hydrogel applications were further discussed, its potential solutions future research developments field biomedicine highlighted.

Язык: Английский

Acid-responsive contractile hyaluronic acid-based hydrogel loaded with ginsenoside Rg1 for hemostasis and promotion of gastric wound healing

Biomaterials, Год журнала: 2025, Номер 321, С. 123320 - 123320

Опубликована: Апрель 5, 2025

Язык: Английский