Neohesperidin Mitigates High-Fat-Diet-Induced Colitis In Vivo by Modulating Gut Microbiota and Enhancing SCFAs Synthesis
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(2), С. 534 - 534
Опубликована: Янв. 10, 2025
Previous
research
has
consistently
shown
that
high-fat
diet
(HFD)
consumption
can
lead
to
the
development
of
colonic
inflammation.
Neohesperidin
(NHP),
a
naturally
occurring
flavanone
glycoside
in
citrus
fruits,
anti-inflammatory
properties.
However,
efficacy
and
mechanism
NHP
countering
prolonged
HFD-induced
inflammation
remains
unclear.
In
this
study,
rats
on
HFD
were
intragastrically
administered
(i.g.)
with
for
12
consecutive
weeks.
Results
indicate
natural
compound
is
effective
reducing
colorectal
at
doses
40-80
mg/kg
body
weight
(BW)
by
i.g.
administration,
significant
decreases
markers
such
as
TNF-α
IL-1β
levels.
It
also
improved
intestinal
mucosal
tissue
integrity
reduced
HFD-stimulated
via
JAK2/STAT3
pathway.
Furthermore,
microbiota
sequencing
results
show
intervention
significantly
downregulated
Firmicutes/Bacteroidetes
ratio.
This
ratio
closely
related
preventive
role
context
glycolipid
metabolism
disorder.
Compared
fecal
cultures
from
group,
after
48
h
vitro
fermentation,
those
group
had
distinct
composition
notably
higher
concentrations
SCFAs.
Collectively,
these
observations
suggest
80
BW
possesses
biological
activities
downregulating
regulating
flora
promoting
SCFAs
formation.
Язык: Английский
In vitro simulated digestion and fermentation characteristics of polyphenol–polysaccharide complex from Hizikia fusiforme and its effects on the human gut microbiota
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 140619 - 140619
Опубликована: Фев. 1, 2025
Язык: Английский
Fucoidan derived from Saccharina japonica: structural characterization and amelioration of high-fat-diet induced obesity in male C57BL/6 J mice via modulating the gut microbiota and lipid metabolites
Qi Lin,
Linjing Zheng,
Weipeng Pan
и другие.
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 143026 - 143026
Опубликована: Апрель 1, 2025
Язык: Английский
In Vivo Tissue Distribution and Pharmacokinetics of FITC-Labelled Hizikia fusiforme Polyphenol–Polysaccharide Complex in Mice
Foods,
Год журнала:
2024,
Номер
13(18), С. 3019 - 3019
Опубликована: Сен. 23, 2024
In
this
study,
a
quantitative
method
based
on
fluorescein
isothiocyanate
(FITC)-labelled
Язык: Английский