From Genes to Healing: The Protective Mechanisms of Poria cocos Polysaccharide in Endometrial Health

Current Issues in Molecular Biology, Год журнала: 2025, Номер 47(3), С. 139 - 139

Опубликована: Фев. 21, 2025

The aim of this study is to investigate the therapeutic effect Poria cocos polysaccharide (PCP) on bovine endometritis. Initially, an inflammation model was induced using LPS-treated endometrial epithelial cells (BEND) identify differentially expressed genes (DEGs) between control and LPS groups by transcriptome sequencing, GO functional annotation KEGG enrichment analysis were performed. Subsequently, mechanism PCP treatment for endometritis further evaluated protein immunoblotting real-time fluorescence quantitative analysis. Finally, efficacy in treating a rat established with mixed bacterial infection. results show that sequencing identified 4367 DEGs, highlighting primary influences cell cycle apoptosis signaling pathways. Following BEND resulted inflammatory response. However, introduction intervention significantly inhibited progression inflammation. Animal test indicate decreases levels serum rats suffering from enhances antioxidant capacity. Furthermore, it effectively improved uterine swelling tissue vacuolization caused These findings suggest could alleviate modulating response suppressing apoptosis. polysaccharides demonstrate significant potential applications immune modulation, anti-inflammatory responses, activities. Their high safety profile makes them suitable candidates as alternative agents veterinary field.

Язык: Английский

Ultrasound-Assisted extraction and purification of polysaccharides from Boschniakia rossica: Structural Characterization and antioxidant potential

Ultrasonics Sonochemistry, Год журнала: 2025, Номер unknown, С. 107364 - 107364

Опубликована: Апрель 1, 2025

Язык: Английский