GC-MS Profiling of Ethanol-Extracted Polyherbal Compounds from Medicinal Plant (Citrullus colocynthis, Curcuma longa, and Myristica fragrans): In Silico and Analytical Insights into Diabetic Neuropathy Therapy via Targeting the Aldose Reductase
Current Issues in Molecular Biology,
Год журнала:
2025,
Номер
47(2), С. 75 - 75
Опубликована: Янв. 23, 2025
Diabetic
neuropathy
is
one
of
the
severe
complications
diabetes,
which
affects
quality
life
in
a
patient
and
increases
risk
amputations
chronic
wounds.
Current
therapeutic
approaches
are
symptomatically
oriented,
focusing
on
comfort
non-inflammatory
aspects
without
addressing
mechanism
or
molecular
target
disease.
The
present
study
investigates
effects
an
ethanolic
polyherbal
extract
from
Citrullus
colocynthis
(Bitter
Apple),
Curcuma
longa
(Turmeric),
Myristica
fragrans
(Nutmeg)
using
advanced
silico
analytical
methods.
According
to
findings,
PHE
showed
presence
total
39
bioactive
compounds
GC–MS
analysis,
include
alcohols,
fatty
acids,
terpenoids,
esters,
neolignans,
phenylpropanoids,
steroids.
Three
compounds—-4-isopropyl-1,6-dimethyl-1,2,3,4-tetrahydronaphthalene
(−11.4
kcal/mol),
(1S,2R)-2-(4-allyl-2,6-dimethoxyphenoxy)-1-(3,4,5-trimethoxyphenyl)-1-propanol
(−9.8
kcal/mol)
(S)-5-Allyl-2-((1-(3,4-dimethoxyphenyl)propan-2-yl)oxy)-1,3-dimethoxybenzene
(−10.3
kcal/mol)—followed
Lipinski
rule
binding
affinity
with
aldol
reductase.
Docking
experiments
that
compound
4-isopropyl-1,6-dimethyl-1,2,3,4-tetrahydronaphthalene
has
high-affinity
aldose
reductase,
enzyme
involved
diabetic
pathophysiology,
whereas
dynamics
simulations
show
long-range
persistence
interaction
reductase
physiological
conditions.
Therefore,
this
combination
herbal
therapy
computational/analytical
techniques
could
be
leading
towards
innovative,
multi-targeted
therapies
against
neuropathy.
Nevertheless,
further
studies
vivo
required
confirm
efficacy,
safety,
pharmacokinetics
biological
systems.
Язык: Английский
Investigation of Aldose Reductase Inhibitors: Implications for Therapeutic Targets in Diabetic Retinopathy
Journal of Molecular Structure,
Год журнала:
2025,
Номер
unknown, С. 142004 - 142004
Опубликована: Март 1, 2025
Язык: Английский
The Relationship Between Hand Abnormalities and Diabetic Retinopathy in Patients with Type 2 Diabetes Mellitus
Journal of Clinical Medicine,
Год журнала:
2024,
Номер
13(22), С. 6723 - 6723
Опубликована: Ноя. 8, 2024
The
link
between
diabetes
mellitus
(DM)
and
pathological
conditions
of
the
hand
has
been
previously
investigated.
Retinopathy
is
one
most
common
microvascular
complications
DM.
In
this
study,
we
aimed
to
evaluate
relationship
abnormalities
retinopathy
in
patients
with
type
2
Язык: Английский
Advances in Understanding Diabetic Kidney Disease Progression and the Mechanisms of Acupuncture Intervention
International Journal of General Medicine,
Год журнала:
2024,
Номер
Volume 17, С. 5593 - 5609
Опубликована: Ноя. 1, 2024
Diabetic
kidney
disease
(DKD)
is
a
form
of
damage
resulting
from
diabetes
and
represents
common,
severe
complication
the
disease.
Globally,
DKD
leading
cause
chronic
(CKD).
occurs
in
both
type
1
2
patients,
with
early
clinical
manifestations
including
microalbuminuria
hypertension.
As
condition
progresses,
symptoms
such
as
massive
proteinuria,
hypoalbuminemia,
edema
may
appear.
The
key
to
treating
lies
controlling
blood
glucose
pressure,
reducing
slowing
deterioration
function.
Acupuncture,
traditional
Chinese
medicine
treatment,
has
shown
some
therapeutic
effects
on
through
mechanisms
regulating
glucose,
improving
renal
flow
microcirculation,
antioxidation
anti-inflammation,
modulating
gut
microbiota.
Язык: Английский