Pharmacological targets and therapeutic mechanisms of Arabic gum in treating diabetic wounds: insights from network pharmacology and experimental validation
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 20, 2025
On
account
of
the
long-term
inflammatory
microenvironment,
diabetic
wounds
are
challenging
to
heal
in
which
advanced
glycation
end
products
considered
important
factors
hindering
healing
wounds.
Gum
Arabic
has
demonstrated
significant
potential
treatment
various
diseases
owing
its
anti-inflammatory
and
antioxidant
properties.
Nonetheless,
there
is
still
insufficient
research
on
role
gum
facilitating
mechanisms.
This
study
aims
investigate
pharmacological
targets
therapeutic
mechanisms
wound
by
adopting
network
pharmacology,
molecular
docking,
experimental
validation.
Key
active
components
disease
were
identified
through
pharmacology
bioinformatics.
GO/KEGG
enrichment
was
performed
identify
critical
pathways.
Cytoscape
AutoDock
used
for
prediction
docking
In
vitro,
Transwell
assay
tube
formation
evaluate
effect
human
fibroblasts
migration
umbilical
vein
endothelial
cells
angiogenesis.
Western
blotting
analyzed
Pro-caspase-1,
ASC,
NLRP3
NF-κB
pathway-related
proteins.
vivo,
a
full-thickness
model
established.
Histological
changes
assessed
via
H&E
Masson's
staining,
oxidative
stress
levels
DHE
inflammation
with
IL-1β,
CD68
CD206
angiogenesis
cell
proliferation
CD31
Ki67
staining.
The
proteins
Phospho-NF-κB
P65
Network
analysis
key
targets,
encompassing
HSP90AA1,
STAT3,
PRKCB,
involved
AGEs-NF-κB-NLRP3
signaling
axis.
Molecular
strong
binding
affinity
between
AG
these
targets.
lessened
AGEs-induced
activation
inflammasome
modulation
pathway
reinforced
AG-treated
exhibited
accelerated
healing,
augmented
collagen
deposition,
lowered
inflammation,
strengthened
promotes
modulating
axis,
exerting
anti-inflammatory,
antioxidant,
pro-angiogenic,
cell-proliferative
effects.
provides
new
insights
into
repair
suggests
that
promising
agent
improving
healing.
Язык: Английский
Efficacy of Kangfuxin liquid for preventing and treating chemotherapy-induced oral mucositis: a systematic review and meta-analysis of randomized controlled trials
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 8, 2025
Chemotherapy-induced
oral
mucositis
(CTOM)
is
a
common
side
effect
affecting
20%-40%
of
cancer
patients
receiving
chemotherapy.
Kangfuxin
liquid
(KFXL)
has
been
used
clinically
to
prevent
and
treat
CTOM,
but
the
evidence
not
systematically
evaluated.
This
study
aimed
evaluate
preventive
therapeutic
effects
KFXL
on
CTOM.
Nine
electronic
databases
were
searched
identify
KFXL-related
randomized
controlled
trials
(RCTs)
for
prevention
treatment
CTOM
from
inception
September
2024.
The
primary
outcomes
incidence
rate,
efficacy
rate
cure
secondary
was
healing
time.
Twenty-one
involving
1825
included
in
this
review.
results
our
meta-analysis
showed
that,
compared
with
basic
care
(BOC),
significantly
reduced
severe
(RR
=
0.54,
p
<
0.00001;
RR
0.23,
0.00001,
respectively),
improved
1.23,
0.0003;
1.99,
0.05,
2.06,
0.0004),and
accelerated
process
(MD
-2.48,
0.00001).
However,
other
drugs
have
same
treating
1.00,
0.99;
0.91,
0.39),
time
-0.01,
1.00).
suggest
that
may
provide
more
benefit
BOC.
Although
be
promising
drug
insufficient
prove
its
superiority
over
guideline-recommended
treatment.
https://www.crd.york.ac.uk/PROSPERO/view/CRD42024585859,
ID:
CRD42024585859.
Язык: Английский