Recent Advances in Metal–Organic Framework-Based Anticancer Hydrogels
Gels,
Год журнала:
2025,
Номер
11(1), С. 76 - 76
Опубликована: Янв. 18, 2025
Cancer
is
the
second
leading
cause
of
death
globally
and
estimated
number
new
cancer
cases
deaths
will
be
∼30.2
million
16.3
million,
respectively,
by
2040.
These
numbers
massive,
physical,
emotional,
financial
burdens
to
society
healthcare
system
that
lead
further
research
for
a
better
more
effective
therapeutic
strategy
manage
cancer.
Metal–organic
frameworks
(MOFs)
are
promising
alternative
approaches
efficient
drug
delivery
theranostics
owing
their
unique
properties
direct
transportation
drugs
into
cells
followed
controlled
release,
but
they
suffer
from
certain
limitations
like
rigidity,
poor
dispersibility,
fragility,
aggregation
probability,
limited
surface
accessibility.
Therefore,
MOFs
were
conjugated
with
polymeric
hydrogels,
formation
MOF-based
hydrogels
abundant
absorption
sites,
flexibility,
excellent
mechanical
properties.
This
review
briefly
describes
different
strategies
used
synthesis
characterization
hydrogels.
Further,
we
place
special
emphasis
on
recent
advances
in
cancers.
Finally,
conclude
challenges
future
perspectives
We
believe
this
help
researchers
develop
augmented
anticancer
effects,
enabling
management
even
without
adverse
effects.
Язык: Английский
Progress of metal-organic frameworks in improving the effect of sonodynamic therapy
Biomedical Technology,
Год журнала:
2025,
Номер
9, С. 100070 - 100070
Опубликована: Фев. 14, 2025
Язык: Английский
Development and Application of Organic Sonosensitizers in Cancer Therapy
Aggregate,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 11, 2025
ABSTRACT
Sonodynamic
therapy
(SDT)
is
an
innovative
cancer
modality
that
harnesses
the
energy
of
ultrasound
to
activate
sonosensitizers
for
producing
reactive
oxygen
species
(ROS),
culminating
in
eradication
tumor
cells.
Compared
with
photodynamic
therapy,
SDT
has
capacity
penetrate
deeply
into
biological
tissues,
thereby
holding
significant
promise
addressing
situated
or
surgically
inaccessible
tumors.
The
effectiveness
greatly
dependent
on
characteristics
sonosensitizers,
and
unlike
inorganic
organic
offer
a
more
controlled
synthesis
process
have
excellent
biocompatibility.
This
review
presents
meticulous
undertaking
categorize
elucidate
their
mechanisms
action
therapeutic
effects
context
SDT.
Design
strategies
are
also
summarized,
we
emphasize
critical
role
nanotechnology
localization,
imaging,
multimodal
synergistic
offering
approach
achieving
precise
targeting.
In
addition,
impact
delineated
when
integrated
other
oncological
modalities,
such
as
photothermal
enhance
efficacy.
Finally,
discusses
challenges
future
perspectives
advancement
clinical
within
realm
oncology.
Язык: Английский