Purification, structural characterization, and in vitro immunomodulatory activity of a low-molecular-weight polysaccharide from cultivated Chinese cordyceps

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 140394 - 140394

Опубликована: Янв. 1, 2025

Язык: Английский

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Structural characterizations and antiaging activities of hydrolyzed low-molecular-weight polysaccharides from Polygoni Multiflori Radix Praeparata

Carbohydrate Polymers, Год журнала: 2025, Номер 356, С. 123381 - 123381

Опубликована: Фев. 14, 2025

Язык: Английский

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Effects of extraction and modifications on physicochemical characteristics and bioactivities of lemon (Citrus limon L.) polysaccharides

Food Bioscience, Год журнала: 2025, Номер unknown, С. 105943 - 105943

Опубликована: Янв. 1, 2025

Язык: Английский

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Microbiota Involved in the Degradation of Tremella fuciformis Polysaccharide and Microbial Enzymatic Potential Revealed by Microbiome and Metagenome

Microorganisms, Год журнала: 2025, Номер 13(2), С. 263 - 263

Опубликована: Янв. 25, 2025

Tremella fuciformis, as a traditional edible fungus in Asian countries, is rich polysaccharides with variety of bioactivities. Nevertheless, its high molecular weight and complex structure have caused limitations application structural analysis. In this study, we successfully screened fuciformis polysaccharide-degrading bacterium from the soil by enriching screening. The mixed consisted mainly Verrucomicrobium (55.4%) Lysobacter (43.8%), which released extracellular enzymes that enabled degradation polysaccharides. functional annotation using microbiome metagenome combined bioinformatics revealed active carbohydrate metabolism, binding, catalysis. It exposed enzymatic potential provided basis for exploration hydrolytic hardly degradable fungi.

Язык: Английский

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Investigation of the fingerprint-activity relationship of Tremella fuciformis polysaccharides and its mitigating effect on radiation-induced intestinal injury

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 140849 - 140849

Опубликована: Фев. 1, 2025

Язык: Английский

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Alleviation of DSS-induced colitis by Meconopsis polysaccharides correlated with reduced PI3K/AKT signaling and gut microbiome diversity

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Фев. 12, 2025

Introduction Inflammatory bowel disease (IBD) is a recurrent gastrointestinal disorder that significantly impacts patients’ quality of life globally. This study focuses on the polysaccharides (MP) extracted from Meconopsis integrifolia , to investigate its role in alleviating DSS (dextran sulfate sodium)-induced colitis mice. Methods The commenced with comprehensive chemical characterization . Subsequently, colitis-alleviating activity MP was validated through vivo experiments. Results results revealed primarily composed ten monosaccharides, exhibits good thermal stability, and has relatively uniform molecular weight distribution. In experiments demonstrated mitigated DSS-induced loss, increased DAI, colon shortening, tissue damage Furthermore, reduced levels inflammatory cytokines such as IL-1β, TNF-α, IL-6 serum. Mechanistically, exerted anti-inflammatory effects by inhibiting activation PI3K/AKT signaling pathway. Additionally, promoted gut microbiota diversity regulated SCFA concentrations, contributing an improved intestinal microenvironment alleviation symptoms. Discussion Our findings highlight superior effectiveness open new avenues for targeted therapeutic strategies treatment IBD.

Язык: Английский

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The effects of degraded polysaccharides from Acanthopanax senticosus on growth, antioxidant and immune effects in broiler chicks based on intestinal flora

Poultry Science, Год журнала: 2025, Номер unknown, С. 104933 - 104933

Опубликована: Фев. 1, 2025

The aim of this study was to evaluate the effect degraded polysaccharide Acanthopanax senticosus (ASPS-1) on immunological effects and appropriate dosage broiler chicks with a view developing new feed additive. For experimental design, 180 were randomly divided into six groups, ASPS-1 low, medium high dose undegraded (ASPS) low groups blank control group. drug administered for 21 consecutive days, growth data immune organ index factors recorded 7th, 14th 21st d. Finally, intestinal flora investigated by high-throughput sequencing 16S rRNA gene correlation between main indexes analyzed, function microbial community predicted using PICRUSt2. results showed that addition could promote body weight chicks, had no significant organs, significantly promoted increase villi crypt ratio, effectively regulated levels serum antioxidant indexes. Analysis ASPS-1H proliferation Lactobacillus, Faecalibacterium, Negativibacillus, Eubacterium inhibited colonization Desulfovibrio Turicibacter, Negativibacillus associated development villi. Predictive analysis PICRUSt2 indicates functions through amino acid metabolism, global overview maps, replication repair pathways function. In summary, doses can improve immunity broilers has potential be used as

Язык: Английский

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Structural determination, immunomodulatory activity, and antitumor activity of a low-molecular-weight polysaccharide extracted from Lepista sordida

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 307, С. 141973 - 141973

Опубликована: Март 11, 2025

Язык: Английский

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The structure-activity relationship of polysaccharides in fruits and vegetables and interaction between polysaccharides and anthocyanins/proteins: A review

Food Research International, Год журнала: 2025, Номер unknown, С. 116371 - 116371

Опубликована: Апрель 1, 2025

Язык: Английский

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Ultrasound-Assisted extraction and purification of polysaccharides from Boschniakia rossica: Structural Characterization and antioxidant potential

Ultrasonics Sonochemistry, Год журнала: 2025, Номер unknown, С. 107364 - 107364

Опубликована: Апрель 1, 2025

Язык: Английский

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