In Vitro Biocompatibility and Wound Healing Potential of Bilayered Scaffold With Electrospun Gentamicin‐Loaded Pullulan/PVA/Gum Arabic Nanofibers and Solvent‐Casted PLA

Journal of Applied Polymer Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 15, 2025

ABSTRACT Wound healing, especially for severe injuries, require dressings that absorb exudate, prevent infection, and support healing without causing trauma upon removal. Traditional single‐layered often fail to balance moisture retention protection, hindering optimal healing. To address this, a bilayered scaffold was fabricated comprising an electrospun hydrophilic sublayer of Pullulan/Polyvinyl alcohol (PVA)/Gum arabic blend loaded with Gentamicin solvent‐casted hydrophobic top layer Polylactic acid (PLA). The designed direct wound contact ease dressing removal, while the enhance mechanical properties, loss, protect against external environment. exhibited antibacterial activity Staphylococcus aureus Escherichia coli , controlled release 93.09% ± 2.63% within 48 h, best described by zero‐order model ( R 2 = 0.9850). It demonstrated swelling index 611.85% 15.05%, indicating its excellent exudate absorbing capacity. water vapor transmission rate (WVTR) porosity were 94.20 14.50 g/m /day 70.56% 0.58%, respectively, both falling permissible range Additionally, in vitro biocompatibility assays conducted on human dermal fibroblast (HDF) cells confirmed noncytotoxicity applicability applications.

Язык: Английский

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Coaxially Electrocentrifugally Spun Ciprofloxacin/Paclitaxel‐Loaded Pullulan/PLGA Core/Sheath Nanofibers and Their In Vitro Cytotoxic Efficacy Toward Melanoma Cells

Journal of Applied Polymer Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 22, 2025

ABSTRACT The study focuses on the fabrication and characterization of ciprofloxacin (CIP)/paclitaxel (PTX)‐loaded pullulan/poly(lactic‐co‐glycolic acid) (PLGA) core/sheath nanofibers using highly efficient coaxial electrocentrifugal spinning (ECS) technique. In contrast to conventional electrospinning, in‐house developed ECS setup used in this effectively tackled nozzle cleaning issue. study, with varying core‐to‐sheath ratio were fabricated, demonstrating suitable mechanical properties for use biomedical applications. primary objective was determine effect dual drug release kinetics nanofibers. Additionally, vitro demonstrated simultaneous profiles CIP from core PTX sheath. exhibited initial burst 6 h, followed by controlled release, making them targeted therapeutic Moreover, cytotoxicity analysis enhanced cytotoxic efficacy combination toward human melanoma A375 cells. drug‐loaded 23G/1 mm 21G/1 65.37% ± 1.96% 67.82% 1.31% cell viability after 72 indicating significant cytotoxicity. This further highlights possible potentiality treatment their application as delivery systems tunable properties.

Язык: Английский

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Chitosan/water caltrop pericarp extract reinforced active edible film and its efficacy as strawberry coating for prolonging shelf life

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142115 - 142115

Опубликована: Март 1, 2025

Язык: Английский

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Neem gum and its derivatives as potential polymeric scaffold for diverse applications: a review

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 143012 - 143012

Опубликована: Апрель 1, 2025

Язык: Английский

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