Ganoderma lucidum Spore Powder Alleviates Metabolic-Associated Fatty Liver Disease by Improving Lipid Accumulation and Oxidative Stress via Autophagy DOI Creative Commons
Yuxuan Zhang, Jiali Zhou, Lan Yang

и другие.

Antioxidants, Год журнала: 2024, Номер 13(12), С. 1501 - 1501

Опубликована: Дек. 9, 2024

Lipid accumulation and oxidative stress, which could be improved by autophagy, are the “hits” of metabolic-associated fatty liver disease (MAFLD). Ganoderma lucidum spore powder (GLSP) has effect improving function. However, there few reports about its effects on mechanisms impacting MAFLD alleviation. This study investigated GLSP hepatic lipid stress explored role that autophagy played in this effect. The results showed effectively reduced activated livers mice with high-fat-diet-induced palmitic acid-induced hepatocytes. reducing lipogenesis promoting oxidation HepG2 cells. It decreased production ROS, increased activity SOD CAT, mitochondrial membrane potential via Keap1/Nrf2 pathway. alleviating was reversed 3-methyladenine (3-MA), an inhibitor. AMPK pathway In conclusion, attenuate improvement autophagy. paper is first to report through promotion. will shed novel light discovery therapeutic strategies targeting for MAFLD.

Язык: Английский

A review of polysaccharides from Ganoderma lucidum: Preparation methods, structural characteristics, bioactivities, structure-activity relationships and potential applications DOI

Maohui Yang,

Xuemei Qin, Xiaojie Liu

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 140645 - 140645

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

1
Application prospect of polysaccharide in the development of vaccine adjuvants DOI
Lei Feng, Jiarui Zhang,

Chunyan Ma

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 297, С. 139845 - 139845

Опубликована: Янв. 15, 2025

Язык: Английский

Процитировано

0
Ganoderma lucidum Spore Powder Alleviates Metabolic-Associated Fatty Liver Disease by Improving Lipid Accumulation and Oxidative Stress via Autophagy DOI Creative Commons
Yuxuan Zhang, Jiali Zhou, Lan Yang

и другие.

Antioxidants, Год журнала: 2024, Номер 13(12), С. 1501 - 1501

Опубликована: Дек. 9, 2024

Lipid accumulation and oxidative stress, which could be improved by autophagy, are the “hits” of metabolic-associated fatty liver disease (MAFLD). Ganoderma lucidum spore powder (GLSP) has effect improving function. However, there few reports about its effects on mechanisms impacting MAFLD alleviation. This study investigated GLSP hepatic lipid stress explored role that autophagy played in this effect. The results showed effectively reduced activated livers mice with high-fat-diet-induced palmitic acid-induced hepatocytes. reducing lipogenesis promoting oxidation HepG2 cells. It decreased production ROS, increased activity SOD CAT, mitochondrial membrane potential via Keap1/Nrf2 pathway. alleviating was reversed 3-methyladenine (3-MA), an inhibitor. AMPK pathway In conclusion, attenuate improvement autophagy. paper is first to report through promotion. will shed novel light discovery therapeutic strategies targeting for MAFLD.

Язык: Английский

Процитировано

0