Cureus, Год журнала: 2025, Номер unknown
Опубликована: Март 30, 2025
Introduction: Diabetes mellitus (DM) significantly increases the risk and severity of myocardial infarction (MI), contributing to poor cardiovascular outcomes through oxidative stress, inflammation, endothelial dysfunction. Methods: This study evaluates cardioprotective potential biochanin A (BCA), a naturally occurring isoflavonoid with antioxidant anti-inflammatory properties, in streptozotocin (STZ) isoproterenol (ISO)-induced model diabetic (DMI) rats. Male Wistar rats were divided into five groups, including normal controls, STZ+ISO, three BCA-treated groups (5, 10, 20 mg/kg). Results: BCA administration improved electrocardiographic parameters by reducing ST height QT interval prolongation (p < 0.05). It also reduced injury markers (lactate dehydrogenase (LDH), creatinine kinase on bundle (CK-MB), aspartate transaminase (AST), cardiac troponin-T (cTn-T)) dose-dependent manner 0.001). normalized blood pressure, heart rate, left ventricular function, improving maximum minimum rate contraction (+dP/dt, -dP/dt) 0.01). Furthermore, decreased glucose levels lipid profiles lowering total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL) while increasing high-density (HDL) suppressed inflammation tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-1β Oxidative stress markers, malondialdehyde (MDA), reduced, such as glutathione (GSH), superoxide dismutase (SOD), catalase increased enhanced nuclear erythroid 2-related 2 (Nrf2) expression, promoting defense. Histopathological analysis confirmed architecture. Conclusion: These findings highlight BCA's therapeutic agent for managing DMI its dual actions.
Язык: Английский