A glucan from Ganoderma lucidum: structural characterization and the anti-inflammatory effect on Parkinson's Disease via regulating dysfunctions of intestinal microecology and inhibiting TLR4/MyD88/NF-κB signaling pathway

Journal of Ethnopharmacology, Год журнала: 2025, Номер 343, С. 119446 - 119446

Опубликована: Фев. 4, 2025

Язык: Английский

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The application of traditional Chinese medicine polysaccharides in wound healing: A review

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 304, С. 140993 - 140993

Опубликована: Фев. 12, 2025

Язык: Английский

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Structure–function insights of natural Ganoderma polysaccharides: advances in biosynthesis and functional food applications

Natural Products and Bioprospecting, Год журнала: 2025, Номер 15(1)

Опубликована: Март 4, 2025

Abstract Ganoderma polysaccharides (GPs), derived from various species of the genus, exhibit diverse bioactivities, including immune modulation, anti-tumor effects, and gut microbiota regulation. These properties position GPs as dual-purpose agents for medicinal functional food development. This review comprehensively explores structural complexity six key their specific mechanisms action, such TLR signaling in apoptosis pathways activity, prebiotic effects on microbiota. Additionally, structure–activity relationships (SARs) are highlighted to elucidate biological efficacy. Advances green extraction techniques, ultrasonic-assisted enzymatic methods, discussed roles enhancing yield aligning with sustainable production principles. Furthermore, addresses biotechnological innovations polysaccharide biosynthesis, improving efficiency making large-scale feasible. insights, combined ongoing research into bioactivity, provide a solid foundation developing health-promoting products that incorporate GPs. future directions suggested optimize biosynthesis fully harness health benefits these polysaccharides. Graphical abstract

Язык: Английский

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Isolation and Extraction of Gentian Polysaccharide and Its Protective Effect on Chemical Liver Injury

Food Safety and Health, Год журнала: 2025, Номер unknown

Опубликована: Апрель 9, 2025

ABSTRACT This study aimed to isolate Gentian polysaccharide and explore the protective effects of on lipopolysaccharide combined with D‐galactosamine (D‐GaLN/LPS) induced chemical liver injury, theoretical material basis for prevention treatment injury. A water‐soluble (GSBP‐N‐a‐1), an average molecular weight 3.82 kDa, was isolated purified from water extract using Diethylaminoethyl‐cellulose (DEAE) column chromatography, CL‐6B agarose gel Sephadex G25 chromatography. injury model established in mice via intraperitoneal injection D‐GalN/LPS. In vivo experiments showed that crude had a effect models by D‐galactosamine. It may act activating Nrf2‐HO‐1 pathway inhibit oxidation reduce release inflammation.

Язык: Английский

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A glucomannan from defatted Ganoderma lucidum spores: structural characterization and immunomodulatory activity via activating TLR4/MyD88/NF-κB signaling pathway

International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 139195 - 139195

Опубликована: Дек. 1, 2024

Язык: Английский

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