Silk Fibroin/GelMA-Based Hydrogels as a Platform for Tissue Adhesives and Tissue Engineering DOI
Kapil D. Patel,

Kya A. Lamarra,

Prasad Sawadkar

и другие.

ACS Biomaterials Science & Engineering, Год журнала: 2025, Номер unknown

Опубликована: Май 30, 2025

Silk fibroin (SF) and gelatin methacryloyl (GelMA)-based hydrogels are emerging as promising biomaterials for various biomedical applications due to their unique physiological physicochemical properties. This Review highlights the synergistic advantages of SF/GelMA hydrogels, focusing on tunability, biocompatibility, multifunctionality. SF contributes structural integrity mechanical strength through formation crystalline β-sheet domains, while GelMA provides a photo-cross-linkable functionality, facilitating precise modulation properties beneficial cell support. Various cross-linking strategies, including physical (ionic, hydrogen bonding, hydrophobic interaction, formation) chemical (covalent cross-linking, photo-cross-linking, enzymatic), explored optimize enhanced tissue adhesion (skin, muscle, cartilage, bone, tendon, ligament) regeneration applications. Furthermore, we address current key translational challenges such long-term biostability, large-scale production, immune-regulatory pathways successful clinical implementation in regenerative medicine, repair reconstruction.

Язык: Английский

Silk Fibroin/GelMA-Based Hydrogels as a Platform for Tissue Adhesives and Tissue Engineering DOI
Kapil D. Patel,

Kya A. Lamarra,

Prasad Sawadkar

и другие.

ACS Biomaterials Science & Engineering, Год журнала: 2025, Номер unknown

Опубликована: Май 30, 2025

Silk fibroin (SF) and gelatin methacryloyl (GelMA)-based hydrogels are emerging as promising biomaterials for various biomedical applications due to their unique physiological physicochemical properties. This Review highlights the synergistic advantages of SF/GelMA hydrogels, focusing on tunability, biocompatibility, multifunctionality. SF contributes structural integrity mechanical strength through formation crystalline β-sheet domains, while GelMA provides a photo-cross-linkable functionality, facilitating precise modulation properties beneficial cell support. Various cross-linking strategies, including physical (ionic, hydrogen bonding, hydrophobic interaction, formation) chemical (covalent cross-linking, photo-cross-linking, enzymatic), explored optimize enhanced tissue adhesion (skin, muscle, cartilage, bone, tendon, ligament) regeneration applications. Furthermore, we address current key translational challenges such long-term biostability, large-scale production, immune-regulatory pathways successful clinical implementation in regenerative medicine, repair reconstruction.

Язык: Английский

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