Immunity Inflammation and Disease, Год журнала: 2024, Номер 12(9)
Опубликована: Сен. 1, 2024
This study aimed to evaluate six novel lymphocyte-based inflammatory markers (neutrophil-lymphocyte ratio, monocyte-lymphocyte platelet-lymphocyte ratio [PLR], systemic immune inflammation index [SII], response index, and [SIIRI]) in patients with newly diagnosed coronary artery disease [CAD].
Язык: Английский
Journal of Diabetes Investigation, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 6, 2024
Previous studies have shown higher cardiovascular mortality risk with monocyte-lymphocyte ratio levels in general population. However, the of oxidative stress individuals type 2 diabetes are than those population, which may affect link between monocyte-to-lymphocyte and disease deaths. And association people still be unknown. This study aimed to investigate prognostic significance diabetes.
Язык: Английский
Процитировано
3
Journal of Clinical Medicine, Год журнала: 2024, Номер 14(1), С. 122 - 122
Опубликована: Дек. 28, 2024
Background/Objectives: Some calculated total blood count readings are investigated as novel additional to help with evaluation of personalized CAD patients’ clinical management and prognosis. We aimed investigate the association between such NLR, MLR, PLR, NMR, LMR, MHR, SII, SIRI severity in patients SAP. Methods: This retrospective pilot study included 166 patients. All underwent CA or CCTA, both, assess CAD. Patients were divided three ways: (1) according presence (n = 146) absence 20) CAD; (2) Gensini score; (3) CAD-RADS score. Results: had lower higher SIRI, SII compared without (p < 0.001 p 0.018, respectively for SII). According by score, values increase LMR decreases gradually 0.001). A moderate correlation was found (r 0.511, 0.001), NLR 0.567, 0.474, 0.001) MLR a low corelation score 0.356, 0.001; r −0.355, 0.001, respectively). The weakly correlated MHR 0.365, 0.346, respectively), moderately −0.454, 0.455, 0.522, Conclusions: appear be potential predictors chronic inflammation, is best predictor degree atherosclerosis all other assessed parameters.
Язык: Английский
Процитировано
3
Diagnostics, Год журнала: 2025, Номер 15(2), С. 162 - 162
Опубликована: Янв. 13, 2025
Background: Fractional Flow Reserve (FFR) is a method that enables the hemodynamic assessment of coronary artery stenosis. The Systemic Inflammatory Response Index (SIRI) new marker calculated by multiplying neutrophil-to-lymphocyte ratio (NLR) with monocyte count. It indicative presence and severity disease. This study evaluates relationship between functional significance FFR measurements SIRI in intermediate Methods: A total 294 patients 50–70% stenosis their arteries based on quantitative measurement following angiography who underwent were included before procedure. Total differential leukocyte counts routine biochemical tests performed. Results: 37% found to have positive FFR, while 63% had negative FFR. Significant differences observed neutrophil count, Inflammation (SIRI), cholesterol, amount adenosine used groups (p < 0.05). value 1.16 was 77% sensitive 55% specific for positivity. Multivariate logistic regression analysis identified as an independent predictor Conclusions: Our has demonstrated high values may serve biomarker predicting
Язык: Английский
Процитировано
0
Revista română de medicină de laborator, Год журнала: 2025, Номер 33(1), С. 21 - 28
Опубликована: Янв. 1, 2025
Abstract Background Ischemia with non-obstructive coronary arteries (INOCA) is a frequent syndrome important impact on morbimortality. Systemic inflammation, key pathophysiological mechanism in its development, reflected diverse bio-markers, such as the neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte (MLR) and platelet-to-lymphocyte (PLR). In this retrospective observational study, we aimed to assess value of NLR, MLR PLR predictors all-cause long-term mortality INOCA patients. Methods Acute/ chronic consecutive patients hospitalized from January 2014 December 2019 were included, after excluding pulmonary hypertension, acute non-cardiac pathology, in-hospital mortality. The primary endpoint was Results Our cohort included 238 (62.2% female, mean age 64.1±9.5 years). Of all patients, 14.3% reached during 5.8±1.1 years follow-up. Age (OR=1.10, p <0.001), diabetes mellitus (OR 2.54, =0.01), heart failure (OR=3.73, =0.003), atrial fibrillation (OR=3.52, =0.001), severe valve disease (OR=3.99, NT-proBNP (OR=3.28, 3rd tertile NLR (OR=4.33, <0.001) (OR=4.34, predictors, while not. multivariable analysis baseline prediction model (HR=1.12, (HR=3.78, <0.001). Adding NLR>2.99 (HR=4.58, MLR>0.36 (HR=4.74, or both increased power predictive chi-square 33.00 51.08 ( Conclusions INOCA, independently correlated most accurate NLR>2.99, MLR>0.36, diagnosis failure.
Язык: Английский
Процитировано
0
Diabetology & Metabolic Syndrome, Год журнала: 2025, Номер 17(1)
Опубликована: Март 24, 2025
Abstract Background This study intends to examine any possible correlation between monocyte-to-lymphocyte ratio (MLR) and cardiovascular diseases (CVD). Methods Data from the 1999–2020 National Health Nutrition Examination Survey (NHANES) in USA were analyzed. Heart attacks, angina pectoris, congestive heart failure (CHF), coronary disease (CHD), stroke all covered by CVD. The independent relationships these events MLR levels, as well other inflammatory indices (system inflammation response index (SIRI), aggregate of systemic (AISI), C-reactive protein-to-albumin (CAR)), investigated. Furthermore, interaction tests subgroup analysis performed. Diagnostic capacities also predicted compared using receiver operating characteristic (ROC) curves. Results Males made up 49.63% 46,289 people who recruited this study. prevalence CVD its follows: CHF at 2.99%, CHD 3.72%, pectoris 2.57%, attacks 3.94%, 3.48%, with itself 7.98%. positively correlated. Specifically, smooth curve fittings found a non-linear relationship Moreover, higher levels linked increased rates CHF, CHD, strokes. SIRI wa s have positive outperformed (SIRI, AISI, CAR) terms discriminative capacity accuracy predicting CVD, attack, stroke, according ROC analysis. Conclusions Compared indicators CAR), appears be better for stroke. American adults elevated should aware harm caused Causal inference is, however, limited cross-sectional design dependence on self-reported data. Further longitudinal studies are needed validate findings.
Язык: Английский
Процитировано
0
Life Sciences, Год журнала: 2025, Номер unknown, С. 123594 - 123594
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Апрель 25, 2025
Язык: Английский
Процитировано
0
Frontiers in Neurology, Год журнала: 2025, Номер 16
Опубликована: Май 9, 2025
Background Neuroinflammation is linked to cognitive function. However, epidemiological research on two emerging inflammation markers—the systemic immune-inflammation index (SII) and the response (SIRI)—remains limited in context of performance. This study investigates relationship between SII, SIRI, performance older adults. Methods cross-sectional analysis included 2,194 participants from 2011–2014 National Health Nutrition Examination Survey (NHANES) who met eligibility criteria. Logistic regression, subgroup analysis, restricted cubic spline modeling were used assess associations markers, specifically SII SIRI. Results After adjusting for population weights, with low function had an 541.54 (95% CI: 360.00–796.50, p = 0.037) SIRI 1.28 0.82–2.18, 0.031). In fully adjusted models, higher levels both (OR 0.858, 95% 0.856–0.859) 0.891, 0.889–0.892) significantly associated lower odds normal function, indicating increased risk impairment. Neutrophil-related markers (NC, NLR, SIRI) exhibited strongest inverse associations. Subgroup showed more consistent across demographic behavioral factors, while displayed fewer. RCS indicated a stronger non-linear ( 0.005) compared 0.018) after full adjustment. Conclusion suggests positive association pronounced These findings highlight potential as novel, accessible marker predicting impairment risk.
Язык: Английский
Процитировано
0
Brain Behavior & Immunity - Health, Год журнала: 2025, Номер unknown, С. 101015 - 101015
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0
Animals, Год журнала: 2023, Номер 13(18), С. 2821 - 2821
Опубликована: Сен. 5, 2023
This study investigated the complete blood count (CBC) indices, including neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte (MLR), and platelet-to-lymphocyte (PLR) in dogs with myxomatous mitral valve disease (MMVD) analyzed their correlation conventional biomarkers, as well effect of CBC indices on survival time MMVD. Medical records 75 healthy controls 249 MMVD from March 2015 to October 2022 were analyzed. The NLR, MLR, PLR calculated by dividing absolute counts parameters. Dogs had significantly higher than (all p < 0.0001), especially those symptomatic group pulmonary edema (p 0.0001, = 0.0002, 0.0387, respectively). NLR MLR correlated N-terminal pro-B type natriuretic peptide levels (both 0.0001). showed potential biomarkers for detecting presence 0.0001) severity 0.006, respectively) using receiver operating characteristic curve analysis. negative effects increased confirmed Kaplan-Meier In conclusion, could be cost-effective readily available diagnostic prognostic dogs.
Язык: Английский
Процитировано
6