Is inflammation a missing link between relative handgrip strength with hyperlipidemia? Evidence from a large population-based study
Rui La,
Yunfei Yin,
Wenquan Ding
и другие.
Lipids in Health and Disease,
Год журнала:
2024,
Номер
23(1)
Опубликована: Май 27, 2024
Abstract
Background
Relative
handgrip
strength
(RHGS)
was
positively
correlated
with
healthy
levels
of
cardiovascular
markers
and
negatively
metabolic
disease
risk.
However,
its
association
hyperlipidemia
remains
unknown.
The
present
study
investigated
the
link
between
RHGS
hyperlipidemia,
utilizing
data
from
National
Health
Nutrition
Examination
Survey
(NHANES)
further
examined
hypothesis
that
inflammation
may
serve
a
mediating
role
within
this
relationship.
Methods
Data
were
extracted
4610
participants
in
NHANES
database
spanning
2011–2014
to
explore
correlation
using
multivariate
logistic
regression
models.
Subgroup
analyses
conducted
discern
across
diverse
populations.
Additionally,
smooth
curve
fitting
threshold
effect
analysis
validate
hyperlipidemia.
Furthermore,
potential
on
also
explored.
Results
According
fully
adjusted
model,
[odds
ratio
(OR)
=
0.575,
95%
confidence
interval
(CI)
0.515
0.643],
which
consistently
significant
all
populations,
notably
among
women.
Smooth
substantiated
negative
Moreover,
effects
indicated
white
blood
cell
(WBC)
count,
neutrophil
(Neu)
lymphocyte
(Lym)
count
played
roles
as
mediators,
mediation
ratios
7.0%,
4.3%,
5.0%,
respectively.
Conclusions
This
identified
prominent
Elevated
protective
factor
against
potentially
through
mechanisms
underlying
modulation
inflammatory
processes.
Язык: Английский
Association between cardiovascular health and osteoporotic fractures: a national population-based study
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Янв. 30, 2025
Osteoporotic
fractures
are
a
major
public
health
concern,
particularly
among
the
aging
population,
as
they
significantly
contribute
to
morbidity,
mortality,
and
reduced
quality
of
life.
While
cardiovascular
(CVH)
has
traditionally
been
linked
disease
outcomes,
emerging
evidence
suggests
it
may
also
influence
bone
health.
This
study
investigates
association
between
CVH,
measured
by
Life's
Essential
8
(LE8)
score,
prevalence
osteoporotic
in
U.S.
adults.
cross-sectional
utilized
data
from
National
Health
Nutrition
Examination
Survey
(NHANES)
2005
2018.
A
total
17,606
adults
aged
20
above
were
included
analysis
after
excluding
participants
with
missing
on
CVH
or
fractures.
was
assessed
using
LE8
which
incorporates
eight
modifiable
metrics:
diet,
physical
activity,
tobacco
use,
sleep,
body
mass
index
(BMI),
lipid
levels,
blood
glucose,
pressure.
The
primary
outcome,
fractures,
identified
through
self-reported
confirmed
physician.
Weighted
multivariate
logistic
regression
models
used
estimate
adjusting
for
demographic
health-related
covariates.
Participants
higher
scores
had
lower
In
fully
adjusted
model,
each
1-point
increase
score
associated
1%
reduction
odds
(OR
=
0.99,
95%
CI:
0.98–0.99).
Compared
low
those
moderate
22%
0.78,
CI
0.70–0.87),
high
34%
0.66,
0.56–0.79).
significant
linear
trend
observed
across
different
levels
(P
<
0.001).
Subgroup
analyses
revealed
that
inverse
relationship
consistent
subgroups.
highlights
These
findings
suggest
maintaining
level
health,
be
important
reducing
risk
Public
strategies
integrate
interventions
enhance
overall
outcomes
reduce
societal
burden
both
diseases
osteoporosis.
Язык: Английский
Evaluating the Incremental Value of an Expanded Cardiovascular Health Score for the Prevalence of Abdominal Aortic Calcification Among Middle-aged and Elderly Individuals
International Journal of Cardiology Cardiovascular Risk and Prevention,
Год журнала:
2025,
Номер
unknown, С. 200389 - 200389
Опубликована: Март 1, 2025
Язык: Английский
Associations between life’s essential 8 and femoral neck bone mineral density among adults: A national population-based study
Linjian Liu,
An Zhang,
Xiangjun Xiao
и другие.
Medicine,
Год журнала:
2024,
Номер
103(36), С. e39540 - e39540
Опубликована: Сен. 6, 2024
Osteoporosis
represents
a
significant
public
health
issue,
impacting
both
outcomes
and
economic
costs.
This
research
investigates
how
cardiovascular
health,
as
indicated
by
the
LE8
score,
correlates
with
bone
mineral
density
(BMD).
Data
from
National
Health
Nutrition
Examination
Survey
(NHANES)
spanning
2011
to
2018
were
analyzed
in
this
cross-sectional
analysis,
including
9018
subjects
following
exclusion
of
individuals
lacking
BMD
or
data.
The
comprising
factors
such
diet,
physical
activity,
smoking
status,
sleep
quality,
body
mass
index,
lipid
profiles,
blood
glucose,
pressure,
was
used
evaluate
health.
determined
through
dual-energy
X-ray
absorptiometry
(DXA).
Relationships
between
scores
at
femoral
neck
assessed
using
linear
regression
smooth
curve
fitting
techniques.
Enhanced
linked
improved
neck.
Notably,
10-point
increment
score
associated
rise
0.04
g/cm²
[β
=
0.04,
95%
CI:
0.03–0.05].
data
indicate
strong
positive
association
measured
LE8,
BMD.
These
results
support
development
holistic
strategies
that
promote
potentially
improve
density.
Язык: Английский
Study of the Association Between Diets Containing Nuts and Seeds and the Degree of Abdominal Aortic Calcification
Nutrients,
Год журнала:
2024,
Номер
16(24), С. 4325 - 4325
Опубликована: Дек. 15, 2024
Background:
The
association
between
nuts
and
seeds
(nuts/seeds)
consumption
abdominal
aortic
calcification
(AAC)
has
been
studied
rarely,
if
at
all.
However,
AAC
is
a
good
marker
of
CVD
risk
premature
mortality.
Consequently,
the
present
observational
study
was
conducted.
It
had
two
primary
purposes:
(1)
to
determine
relationship
nuts/seeds
AAC,
(2)
examine
effects
nine
potential
confounding
variables
on
AAC.
Methods:
sample
included
2611
randomly
selected
adults
representative
United
States
population.
Data
were
collected
as
part
National
Health
Nutrition
Examination
Survey
(NHANES).
outcome
measure
divided
into
three
categories:
none,
mild,
moderate/severe.
Total
assessed
utilizing
mean
diet
recall
assessments.
Results:
There
an
inverse
dose–response
categories
with
age,
sex,
race
controlled
(F
=
6.4,
p
0.0233).
After
controlling
for
demographic
physical
activity,
hypertension
status,
waist
circumference,
diabetes
smoking,
minimally
affected
6.0,
0.0268).
Conclusions:
In
conclusion,
appears
differentiate
among
different
levels
Control
many
covariates
little
impact
associations.
recommendations
U.S.
Dietary
Guidelines
(2020–2025)
that
encourage
eating
are
supported
by
results
this
investigation.
Язык: Английский