Mitochondria transfer for myelin repair DOI Creative Commons
Sabah Mozafari, Luca Peruzzotti-Jametti, Stefano Pluchino

и другие.

Journal of Cerebral Blood Flow & Metabolism, Год журнала: 2025, Номер unknown

Опубликована: Март 13, 2025

Demyelination is a common feature of neuroinflammatory and degenerative diseases the central nervous system (CNS), such as multiple sclerosis (MS). It often linked to disruptions in intercellular communication, bioenergetics metabolic balance accompanied by mitochondrial dysfunction cells oligodendrocytes, neurons, astrocytes, microglia. Although current MS treatments focus on immunomodulation, they fail stop or reverse demyelination’s progression. Recent advancements highlight exchange promising therapeutic target, with potential restore homeostasis, enhance promote myelin repair. With this review we will provide insights into CNS decoupling, focusing role demyelinating conditions. We then discuss emerging cell-free biotherapies exploring transferring mitochondria via biogenic carriers like extracellular vesicles (EVs) synthetic liposomes, aimed at enhancing function support for Lastly, address key challenges clinical application these strategies future directions optimize biotherapies. The field hold promise restoring repair, potentially transforming landscape diseases.

Язык: Английский

Mitochondria transfer for myelin repair DOI Creative Commons
Sabah Mozafari, Luca Peruzzotti-Jametti, Stefano Pluchino

и другие.

Journal of Cerebral Blood Flow & Metabolism, Год журнала: 2025, Номер unknown

Опубликована: Март 13, 2025

Demyelination is a common feature of neuroinflammatory and degenerative diseases the central nervous system (CNS), such as multiple sclerosis (MS). It often linked to disruptions in intercellular communication, bioenergetics metabolic balance accompanied by mitochondrial dysfunction cells oligodendrocytes, neurons, astrocytes, microglia. Although current MS treatments focus on immunomodulation, they fail stop or reverse demyelination’s progression. Recent advancements highlight exchange promising therapeutic target, with potential restore homeostasis, enhance promote myelin repair. With this review we will provide insights into CNS decoupling, focusing role demyelinating conditions. We then discuss emerging cell-free biotherapies exploring transferring mitochondria via biogenic carriers like extracellular vesicles (EVs) synthetic liposomes, aimed at enhancing function support for Lastly, address key challenges clinical application these strategies future directions optimize biotherapies. The field hold promise restoring repair, potentially transforming landscape diseases.

Язык: Английский

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