Postgraduate Medicine, Год журнала: 2024, Номер unknown, С. 1 - 7
Опубликована: Ноя. 6, 2024
Objectives The triglyceride-glucose (TyG) index is a novel diagnostic marker for various metabolic and cardiovascular diseases. However, little known about the association of TyG with plasma atherogenicity, especially its latent forms. aim this study was to assess potential use as atherogenic risk.
Язык: Английский
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Янв. 17, 2025
The relationship between the triglyceride‒glucose (TyG) index and clinical prognosis of septic patients in intensive care units (ICUs) remains unclear. This study aimed to explore correlation TyG 28-day all-cause mortality patients. A retrospective observational cohort was conducted, including 8955 from MIMIC IV 2.2 database. primary outcome mortality. Multivariate logistic regression analysis restricted cubic spline were used assess Subgroup analyses sensitivity performed further validate robustness results. total included, 5219 (58.3%) whom male, with a mean age 66.3 (15.8) years an average 9.08 (0.70) number deaths within 28 days 1639 (18.3%). RCS curve demonstrated U-shaped (nonlinear P value = 0.0003). risk negatively associated until it decreased 9.03 (adjusted odds ratio [OR] 0.727, 95% confidence interval [CI] 0.577–0.915). However, when exceeded 9.03, for significantly increased OR 1.185, CI 1.001–1.404). These findings consistent across subgroups various analyses. Our revealed nonlinear mortality, critical point at 9.03. results suggest that may be novel important factor short-term critically ill
Язык: Английский
Процитировано
1
Cardiovascular Diabetology, Год журнала: 2025, Номер 24(1)
Опубликована: Фев. 28, 2025
Cardiovascular-kidney-metabolic (CKM) syndrome has been recently proposed by American Heart Association recently. The triglyceride glucose (TyG) index and TyG-related indices combined with obesity indicators have proven to be associated the incidence of cardiovascular diseases (CVD). However, there are few studies explore whether these associations exist among people CKM stages 0–3. A total 7,364 participants from China Health Retirement Longitudinal Study were included. Cox hazard regression restricted cubic spline used analyze CVD incidence. To compare predictive performance, time-dependent Harrell's C-indices, net reclassification integrated discrimination improvement conducted. was 20.55% over nine years. TyG single all modified capable predicting RCS analyses showed that had linear relationships waist circumference (TyG-WC) or waist-to-height ratio (TyG-WHtR) still existed in stage 1, 2 3. TyG-WC (C-index: 0.621, p < 0.001) TyG-WHtR almost highest C-indices incidence, compared 0.611, body mass 0.616, 0.001). independent predictors It found better especially ratio.
Язык: Английский
Процитировано
1
Lipids in Health and Disease, Год журнала: 2024, Номер 23(1)
Опубликована: Дек. 23, 2024
The Triglyceride-glucose (TyG) index represents a simple, cost-effective, and valid proxy for insulin resistance. This surrogate marker has also been proposed as predictor of metabolic cardiovascular disease (CVD). In this descriptive review, we aimed to assess the utility TyG predictive biomarker cardiometabolic diseases. A search was conducted in PubMed, Web Science identify cross-sectional more importantly prospective studies examining use biomarker. following terms were utilized addition index: "insulin resistance", "metabolic syndrome", "diabetes"; "cardiovascular diseases". review included thirty studies. Following adjustment confounding variables, an elevated associated with significantly increased risk development Metabolic Syndrome (MetS), Type 2 Diabetes, hypertension, CVD. Also limited studies, endothelial dysfunction, oxidative stress pro-inflammatory phenotype. Overall, our findings support developing MetS, T2DM, well atherosclerotic disease.
Язык: Английский
Процитировано
5
Renal Failure, Год журнала: 2025, Номер 47(1)
Опубликована: Янв. 6, 2025
Язык: Английский
Процитировано
0
Cardiovascular Diabetology, Год журнала: 2025, Номер 24(1)
Опубликована: Янв. 13, 2025
Abstract Background The triglyceride-glucose (TyG) index is now widely recognized as a marker of insulin resistance and has been linked to the development prognosis atherosclerotic cardiovascular diseases (ASCVD) in numerous populations, particularly Eastern world. Although there are fewer reports from Western world, they sometimes contradictory, absence definitive data on relationship between raised TyG risk suggested opportunity testing this biochemical against well-established vascular such carotid intima media thickness (c-IMT). Methods Primary prevention patients were selected cohort individuals who underwent c-IMT measurement 1984 2018 at Dyslipidemia Center ASST Grande Ospedale Metropolitano Niguarda Milan, Italy. was calculated Ln [fasting TG (mg/dL)×fasting glucose (mg/dL)/2]. Carotid ultrasonography performed using echographic measurements far walls left right common, internal carotids, bifurcations. Patients followed for up 20 years with periodic evaluation parameters. ASCVD events monitored through hospital records, where all regularly examined. Results analysis included 3108 mean age 54.9 ± 13.1 years. Participants generally non-obese, an average BMI 24.6 3.5 Kg/m 2 . Among women, 83.1% postmenopausal. 8.65 0.59. There significant association measurements. Those highest quartiles had significantly higher IMT max compared those lower quartiles. These associations consistent across sites examined remained after adjusting potential confounders. Kaplan-Meier survival revealed increased incidence two Conclusions sensitive European population moderate risk, assessed by measurements, large Lipid Clinic patients.
Язык: Английский
Процитировано
0
Toxics, Год журнала: 2025, Номер 13(2), С. 118 - 118
Опубликована: Фев. 1, 2025
Using NHANES data from 2003 to 2008, 2011 2012, and 2015 2020, we examined the relationship between urinary organophosphate pesticide (OPP) metabolites triglyceride glucose (TyG) index. The TyG index evaluates insulin resistance, a crucial factor in metabolic diseases. Linear regression analyzed relation OPPs. An RCS (restricted cubic spline) model explored nonlinear of single OPP metabolite TyG. A weighted quantile quantile-based g-computation assessed impact combined exposure on XGBoost, Random Forest, Support Vector Machines, logistic regression, SHapley Additive exPlanations models investigated OPPs cardiovascular disease. Network toxicology identified CVD targets associated with This study included 4429 participants based specific criteria. analysis indicated that diethyl thiophosphate was positively correlated positive correlation at low moderate concentrations confirmed by WQS QGC analyses. machine learning results aligned traditional statistical findings. PTGS3, PPARG, HSP40AA1, CXCL8 as influenced influences IR cardiometabolic health, highlighting importance public health prevention.
Язык: Английский
Процитировано
0
Archives of Gynecology and Obstetrics, Год журнала: 2025, Номер unknown
Опубликована: Фев. 26, 2025
The relationship of the first-trimester triglyceride-glucose (TyG) index with GDM (gestational diabetes mellitus) and other adverse pregnancy outcomes has yet to be fully understood. This study aims investigate between TyG risk in pregnant women. data for retrospective cohort were derived from Maternal Child Health Hospital Longgang District, Shenzhen, China. To calculate index, health indicators measured early period (<14 gestational weeks), including triglycerides fasting blood glucose levels Multivariable regression analysis subgroup used ascertain independent association possibility outcomes. Interaction was performed assess potential heterogeneity associations among subgroups. Nonlinear predictive value explored using restricted cubic splines receiver operating characteristic (ROC) curves. discrimination accuracy adjusted model evaluated calibration curves, Brier scores, decision curve (DCA). Mediation conducted impact PE (preeclampsia) as intermediaries on Preterm delivery. included a 11,942 women, an average 8.36 ± 0.41. Logistic showed that after adjusting covariates, each 1-unit increase increased by 2.21-fold, this result significantly different across all quartiles. Compared lowest quartile group, highest group had (OR: 2.89; 95% CI 1.39 ~ 6.50), GH hypertension) 1.47; 1.07 2.02), delivery 1.75; 1.21 2.56).The stratification interaction confirmed validity our results. However, found no statistically significant low birth weight macrosomia. identified partial mediating factors preterm delivery, variance contributions 7.23% 20.33%. demonstrated area under (AUC) values ROC curves GDM, PE, GH, 0.61, 0.67, 0.58, 0.56, respectively. combination maternal age, pre-pregnancy body mass predicted better than alone (p < 0.01).After adjustment confounders, good net benefit predicting outcomes, supported analysis. An elevated correlates heightened delivery.The presents promising tool more effectively identifying populations at
Язык: Английский
Процитировано
0
Опубликована: Март 1, 2025
Original Research Articles Triglyceride-Glucose (TyG) Index in a Pediatric Non-Diabetic Cohort-Surrogate Marker of Insulin Resistance? Sridevi Devaraj *, Daksha Krishnan and Xinpu Chen Department Pathology & Immunology, Baylor College Medicine, Houston, TX 77030, USA * Correspondence: [email protected] Received: 22 January 2025; Accepted: 13 February Published: 1 March 2025 Abstract: The incidence diabetes obesity has reached epidemic levels. Although insulin resistance is the key pathophysiological mechanism, several surrogate biomarkers such as Homeostatic Model Assessment for Resistance (HOMA-IR), have been proposed. In recent years, research on triglyceride-glucose index useful marker identifying cardio-metabolic risk, particularly adults, rise. However, there paucity data role TyG children adolescents association with HOMA-IR DEXA (dual-energy X-ray absorptiometry), especially North America. Therefore, this study aims to investigate adolescents, explore relationship between American adolescents. Forty-four lean obese were recruited after obtaining informed consent, anthropometric laboratory assessments. was significantly higher than their counterparts (p < 0.001) correlated glucose, BMI, DEXA, triglycerides HOMA-IR. Thus, pilot shows that may serve an excellent assessing risk pediatrics.
Язык: Английский
Процитировано
0
Biomarkers in Medicine, Год журнала: 2025, Номер unknown, С. 1 - 9
Опубликована: Март 29, 2025
This study aimed to investigate whether triglyceride-glucose (TyG) index and other clinical demographic parameters are associated with left ventricular ejection fraction (LVEF) following an acute coronary syndrome (ACS) event. retrospective cohort included patients hospitalized a diagnosis of ACS. The TyG was calculated using the formula: = ln [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]. A total 2,135 were in (mean age: 57.49 ± 11.45 years, 78.64% male). Multivariable logistic regression revealed that mildly reduced or LVEF immigrant population (p 0.004), diabetes mellitus 0.017), previous artery disease (CAD) < 0.001), ST-elevation myocardial infarction (STEMI) 0.001) high (≥4.95) 0.001). Reduced (≤40%) independently status 0.031), CAD peripheral 0.038), renal diseases 0.011), STEMI (≥5.10) shows potential as independent risk factor for low after ACS.However, its relatively sensitivity specificity suggest it may have supportive role stratification. Further research is needed confirm utility reliable prognostic marker heart failure ACS patients.
Язык: Английский
Процитировано
0
Lipids in Health and Disease, Год журнала: 2025, Номер 24(1)
Опубликована: Фев. 14, 2025
Abstract Aim Explore the relationship between triglyceride-glucose (TyG) index, along with its derivative indices, and prevalence of cataracts. Methods Data from 20,497 participants in 2005–2008 National Health Nutrition Examination Survey (NHANES) were compiled. A final total 4,499 individuals met eligibility criteria. Cataract presence was assessed through a self-reported history cataract surgery. The TyG index derivatives—TyG-waist-to-height ratio (WHtR), TyG-neutrophil-to-lymphocyte (NLR), TyG-monocyte-to-lymphocyte (MLR), TyG-log platelet-to-lymphocyte (lgPLR), systemic inflammation (lgSII), TyG-systemic response (SIRI)—were calculated. Statistical analyses included multivariable logistic regression, restricted cubic spline (RCS) curves for nonlinear relationships, receiver operating characteristic (ROC) analysis. Results Higher indices significantly associated ( P < 0.001). Specifically, TyG-WHtR, TyG-NLR, TyG-lgPLR, TyG-lgSII, TyG-SIRI exhibited positive correlations prevalence, even after adjustment potential confounders (odds [OR] = 1.17; 95% confidence interval [CI]: 1.01, 1.37; 0.0403; 1.01; 1.00, 1.02; 0.0258; 1.08; 1.16; 0.0223; 1.03, 1.14; 0.001; 1.04; 0.0120). Furthermore, stratified analysis showed that 61–85 age group, TyG-lgPLR TyG-lgSII remained positively ([OR] 1.09; 0.024; 1.02, 1.13; 0.005). RCS revealed linear association these cataracts, no apparent threshold effect. ROC indicated TyG-MLR demonstrated highest predictive ability presence. Conclusion study results indicate TyG-related indicators cataracts middle-aged elderly individuals, suggesting markers may serve as practical biomarkers identifying high-risk individuals. Early detection management metabolic inflammatory factors could contribute to effective preventive strategies development population.
Язык: Английский
Процитировано
0