Synthesis of new Cu(II), Ni(II), and Cd(II)-(N-Glycyl-L-leucine) complexes as peptide metalloantibiotics for targeting pathogenic water with antioxidant effect investigation DOI Creative Commons
Safaa S. Hassan,

Eman F. Mohamed,

Kirolos Maged

и другие.

Beni-Suef University Journal of Basic and Applied Sciences, Год журнала: 2025, Номер 14(1)

Опубликована: Май 12, 2025

Abstract Background In recent efforts to address the critical need for clean and portable water, we have focused on innovative methods eliminate pathogenic microorganisms. To this aim, N-Glycyl-L-leucine ( Gly-Leu) peptide ligand was complexed with different transition metal ions [Cu(II), Ni(II), Cd(II)] as new metalloantibiotics. The compounds were characterized examined using various analytical methods, including elemental analysis (CHN), Fourier transform infrared spectroscopy (FTIR), assessments of magnetic properties, molar conductivity, 1 HNMR, thermogravimetric (TGA), mass spectroscopy. acted a di-anionic molecule carboxylate deprotonated amide nitrogen atom. coordination sites completed carbonyl oxygen atoms water molecule. complexes showed polymeric structures bridging groups. Results antibacterial properties synthesized chelate evaluated disk diffusion minimum inhibitory concentration bacterial organisms identified from samples taken Nile River. At mg/mL dose, Cu(II)-chelate biggest zone 27 mm against Klebsiella pneumonia, MIC value 62.5 μg/mL, greater than that common gentamicin medication. Molecular docking investigations supported these findings, showing had lowest binding energy − 6.16 kcal/mol, indicating significant, beneficial interactions amino acids in active region proteins. Furthermore, Cu(II) complex COVID-19 main protease encouraging results analysis, may antiviral be able inhibit viral propagation successfully. chelates demonstrated noteworthy antioxidant activity, especially 1,1-diphenyl-2-picrylhydrazyl (DPPH radicals). IC 50 values assay Ni(II) extremely similar ascorbic acid, antioxidant. Their notable capacity by (14.4, 15.5, 18 µg/mL) chelates, respectively. Conclusions Our study successfully potential Gly-Leu ions, particularly Cu(II), eliminating microorganisms water. exhibited superior confirmed both experimental molecular results. also displayed capacity, comparable acid. Additionally, promising potential, theoretically interacting effectively protease, which suggests its ability replication. These underscore multi-functional compound applications purification therapeutic fields.

Язык: Английский

Targeted Colon Cancer and Chemotherapeutic Through Metal Glycoconjugates: Design, Synthesis, Molecular Docking, and DFT Investigations DOI Open Access
Waad A. Al‐Otaibi, Sahar M. AlMotwaa,

Amrajaa S. Abubakr

и другие.

Applied Organometallic Chemistry, Год журнала: 2025, Номер 39(3)

Опубликована: Фев. 7, 2025

ABSTRACT To advance our study on the GLUT's glucose recognition binding site and enhance effectiveness of targeted anticancer compounds based encouraging findings, glycogenated metal complexes have shown promise in combating colon cancer (HCT‐116) through salicylaldehyde‐D‐glucosamine Schiff base(H 2 L), we proceed with research utilizing various cell lines different ions known for their potent effect. Newly synthesized formulae Zn (HL) , (CH 3 ) Sn(HL) [Ru(L)(HL)H O].H O are directed against two (HCT‐116 Caco‐2). Different characterization techniques used to confirm structures. DFT was structurally optimize compounds. The particle size distribution performed all chelates. All revealed remarkable activities especially ligand Ru (III) complex recording IC 50 values 21.73 μg/mL HCT‐116 49.53 Caco‐2 lines, respectively. results showed that can attract sugar‐conjugated efficiency its confirmed evaluation GSH, SOD, MDA, NO, LDH levels. high affinity glycoconjugates DNA explored using electrophoresis. Additionally, chelates significant antimicrobial activity. (II) bactericidal activity strain Helicobacter pylori . docking simulation explore active amino acids participate biological interaction.

Язык: Английский

Процитировано

1
Synthesis and characterization of MIL-88B(Fe) MOF for high-performance humidity sensing DOI
Mohamed Morsy, Safaa Shawky Hassan,

Hoda M. Shaker

и другие.

Sensors and Actuators B Chemical, Год журнала: 2025, Номер 438, С. 137806 - 137806

Опубликована: Апрель 16, 2025

Язык: Английский

Процитировано

1
Synthesis of new Cu(II), Ni(II), and Cd(II)-(N-Glycyl-L-leucine) complexes as peptide metalloantibiotics for targeting pathogenic water with antioxidant effect investigation DOI Creative Commons
Safaa S. Hassan,

Eman F. Mohamed,

Kirolos Maged

и другие.

Beni-Suef University Journal of Basic and Applied Sciences, Год журнала: 2025, Номер 14(1)

Опубликована: Май 12, 2025

Abstract Background In recent efforts to address the critical need for clean and portable water, we have focused on innovative methods eliminate pathogenic microorganisms. To this aim, N-Glycyl-L-leucine ( Gly-Leu) peptide ligand was complexed with different transition metal ions [Cu(II), Ni(II), Cd(II)] as new metalloantibiotics. The compounds were characterized examined using various analytical methods, including elemental analysis (CHN), Fourier transform infrared spectroscopy (FTIR), assessments of magnetic properties, molar conductivity, 1 HNMR, thermogravimetric (TGA), mass spectroscopy. acted a di-anionic molecule carboxylate deprotonated amide nitrogen atom. coordination sites completed carbonyl oxygen atoms water molecule. complexes showed polymeric structures bridging groups. Results antibacterial properties synthesized chelate evaluated disk diffusion minimum inhibitory concentration bacterial organisms identified from samples taken Nile River. At mg/mL dose, Cu(II)-chelate biggest zone 27 mm against Klebsiella pneumonia, MIC value 62.5 μg/mL, greater than that common gentamicin medication. Molecular docking investigations supported these findings, showing had lowest binding energy − 6.16 kcal/mol, indicating significant, beneficial interactions amino acids in active region proteins. Furthermore, Cu(II) complex COVID-19 main protease encouraging results analysis, may antiviral be able inhibit viral propagation successfully. chelates demonstrated noteworthy antioxidant activity, especially 1,1-diphenyl-2-picrylhydrazyl (DPPH radicals). IC 50 values assay Ni(II) extremely similar ascorbic acid, antioxidant. Their notable capacity by (14.4, 15.5, 18 µg/mL) chelates, respectively. Conclusions Our study successfully potential Gly-Leu ions, particularly Cu(II), eliminating microorganisms water. exhibited superior confirmed both experimental molecular results. also displayed capacity, comparable acid. Additionally, promising potential, theoretically interacting effectively protease, which suggests its ability replication. These underscore multi-functional compound applications purification therapeutic fields.

Язык: Английский

Процитировано

0