Vitamin D Status and SARS-CoV-2 Infection and COVID-19 Clinical Outcomes

Frontiers in Public Health, Год журнала: 2021, Номер 9

Опубликована: Дек. 22, 2021

Background: Several studies suggest an association between serum 25-hydroxyvitamin D (25OHD) and the outcomes of Severe Acute Respiratory Syndrome Corona-Virus-2 (SARS-CoV-2) infection, in particular Coronavirus Disease-2019 (COVID-19) related severity mortality. The aim present meta-analysis was to investigate whether vitamin status is associated with COVID-19 severity, defined as ARDS requiring admission intensive care unit (ICU) or mortality (primary endpoints) susceptibility SARS-CoV-2 COVID-19-related hospitalization (secondary endpoints). Methods: A search PubMed, ScienceDirect, Web Science, Google Scholar, Scopus, preprints repositories performed until March 31th 2021 identify all original observational reporting measures, enough data calculate them, Vitamin (insufficiency <75, deficiency <50, severe <25 nmol/L) risk hospitalization, ICU admission, death during hospitalization. Findings: Fifty-four (49 fully-printed 5 pre-print publications) were included for a total 1,403,715 individuals. SARS-CoV2 reported 17, 9, 27, 35 studies, respectively. deficiency, insufficiency (odds ratio [OR], 95% confidence intervals [95%CIs]: 2.63, 1.45–4.77; 2.16, 1.43–3.26; 2.83, 1.74–4.61, respectively), (OR, 95%CIs: 2.60, 1.93–3.49; 1.84, 1.26–2.69; 4.15, 1.76–9.77, infection 1.68, 1.32–2.13; 1.83, 1.43–2.33; 1.49, 1.16–1.91, respectively) 95%CIs 2.51, 1.63–3.85; 2.38, 1.56–3.63; 1.82, 1.43–2.33). Considering specific subgroups (i.e., Caucasian patients, high quality adjusted estimates) results primary endpoints did not change. Interpretations: Patients low levels increased due higher

Язык: Английский

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The Impact of Vitamin D Level on COVID-19 Infection: Systematic Review and Meta-Analysis

Frontiers in Public Health, Год журнала: 2021, Номер 9

Опубликована: Март 5, 2021

Background: Coronavirus disease (COVID-19) is a respiratory and systemic disorder caused by Severe Acute Respiratory Syndrome 2 (SARS-CoV-2) or novel (nCoV). To date, there no proven curative treatment for this virus; as result, prevention remains to be the best strategy combat coronavirus infection (COVID-19). Vitamin D deficiency (VDD) has been proposed play role in However, conclusive evidence on its impact COVID-19 infection. Therefore, present review aimed summarize available regarding association between levels risk of Methods: A systematic literature search databases (PUBMED/MEDLINE, Cochrane/Wiley library, Scopus, SciELO) were conducted from May 15, 2020, December 20, 2020. Studies that assessed effect vitamin level COVID-19/SARS-2 considered review. The qualities included studies evaluated using JBI tools. Meta-analysis with random-effects model was odds ratio their 95%CI reported. This meta-analysis are reported according preferred reporting items (PRISMA) guideline. Results: electronic supplementary searches yielded 318 records which, only 14 them met inclusion criteria. qualitative synthesis indicated deficient individuals at higher compared sufficient patients. pooled analysis showed Vitamin-D 80% more likely acquire those who have (OR = 1.80; 95%CI: 1.72, 1.88). Begg's test also revealed significant publication bias ( P 0.764). subgroup acquiring relatively case-control study design 1.81). Conclusions: In conclusion, low serum 25 (OH) significantly associated limited currently data suggest decreased

Язык: Английский

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Vitamin D: Dosing, levels, form, and route of administration: Does one approach fit all?

Reviews in Endocrine and Metabolic Disorders, Год журнала: 2021, Номер 22(4), С. 1201 - 1218

Опубликована: Дек. 1, 2021

The 4

Язык: Английский

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Prognostic and Therapeutic Role of Vitamin D in COVID-19: Systematic Review and Meta-analysis

The Journal of Clinical Endocrinology & Metabolism, Год журнала: 2021, Номер 107(5), С. 1484 - 1502

Опубликована: Дек. 11, 2021

Abstract Purpose Vitamin D deficiency/insufficiency may increase the susceptibility to coronavirus disease 2019 (COVID-19). We aimed determine association between vitamin and COVID-19, its severity, mortality, role of in treatment. Methods searched CINAHL, Cochrane library, EMBASE, PubMED, Scopus, Web Science up May 30, 2021, for observational studies on severe disease, death among adults, and, randomized controlled trials (RCTs) comparing treatment against standard care or placebo, improving severity mortality adults with COVID-19. Risk bias was assessed using Newcastle-Ottawa scale AUB-KQ1 tool RCTs. Study-level data were analyzed RevMan 5.3 R (v4.1.0). Heterogeneity determined by I2 sources explored through prespecified sensitivity analyses, subgroup meta-regressions. Results Of 1877 search results, 76 satisfying eligibility criteria included. Seventy-two included meta-analysis (n = 1 976 099). increased odds developing COVID-19 (odds ratio [OR] 1.46; 95% CI, 1.28-1.65; P < 0.0001; 92%), (OR 1.90; 1.52-2.38; 81%), 2.07; 1.28-3.35; 0.003; 73%). The 25-hydroxy concentrations lower individuals compared controls (mean difference [MD] -3.85 ng/mL; -5.44 -2.26; ≤ 0.0001), patients nonsevere (MD -4.84 -7.32 -2.35; 0.0001) nonsurvivors survivors -4.80 -7.89 -1.71; 0.002). insignificant when high risk reporting unadjusted effect estimates excluded. heterogeneity across all analyses. Discrepancies timing testing, definitions partly explained heterogeneity. Four RCTs widely heterogeneous precluding meta-analysis. Conclusion Multiple involving nearly 2 million suggest increases although a Association less robust. precluded their

Язык: Английский

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Vitamin D supplementation for the treatment of COVID-19: a living systematic review

Cochrane library, Год журнала: 2021, Номер 2021(5)

Опубликована: Май 24, 2021

Язык: Английский

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Efficacy and Safety of Vitamin D Supplementation to Prevent COVID-19 in Frontline Healthcare Workers. A Randomized Clinical Trial

Archives of Medical Research, Год журнала: 2022, Номер 53(4), С. 423 - 430

Опубликована: Апрель 18, 2022

Язык: Английский

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Blood omega-3 fatty acids and death from COVID-19: A pilot study

Prostaglandins Leukotrienes and Essential Fatty Acids, Год журнала: 2021, Номер 166, С. 102250 - 102250

Опубликована: Янв. 20, 2021

Very-long chain omega-3 fatty acids (EPA and DHA) have anti-inflammatory properties that may help reduce morbidity mortality from COVID-19 infection. We conducted a pilot study in 100 patients to test the hypothesis RBC EPA+DHA levels (the Omega-3 Index, O3I) would be inversely associated with risk for death by analyzing O3I banked blood samples drawn at hospital admission. Fourteen died, one of 25 quartile 4 (Q4) (O3I ≥5.7%) 13 75 Q1-3. After adjusting age sex, odds ratio an Q4 vs Q1-3 was 0.25, p = 0.07. Although not meeting classical criteria statistical significance, this strong trend suggests relationship indeed exist, but more well-powered studies are clearly needed.

Язык: Английский

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“Vitamin D supplementation and COVID-19 treatment: A systematic review and meta-analysis”

Diabetes & Metabolic Syndrome Clinical Research & Reviews, Год журнала: 2021, Номер 15(4), С. 102189 - 102189

Опубликована: Июнь 28, 2021

Язык: Английский

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Effects of the COVID pandemic on pregnancy outcomes

Best Practice & Research Clinical Obstetrics & Gynaecology, Год журнала: 2021, Номер 73, С. 125 - 136

Опубликована: Март 19, 2021

Pregnant women and neonates are often categorised as being at high risk during the coronavirus disease-2019 (COVID-19) pandemic. Numerous studies have demonstrated that characteristics of COVID-19 disease in pregnant non-pregnant very similar. However, with third trimester more likely than their counterparts to require intensive care, though this may reflect a lower threshold for intervention rather serious disease. Compared without COVID-19, symptomatic requiring admission hospital worse maternal outcomes, including death, although absolute remains low. Outcomes born positive generally good, iatrogenic preterm birth is common. Findings from these highlight need further monitoring outcomes post-partum according

Язык: Английский

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Vitamin D and SARS-CoV2 infection, severity and mortality: A systematic review and meta-analysis

PLoS ONE, Год журнала: 2022, Номер 17(7), С. e0268396 - e0268396

Опубликована: Июль 6, 2022

To assess the evidence on SARS-CoV2 infection and Covid-19 in relation to deficiency supplementation of vitamin D, we conducted a systematic review up April 2021. We summarised data from 38 eligible studies, which presented risk estimates for at least one endpoint, including two RCT 27 cohort-studies: 205565 patients with information 25OHD status 2022 taking D total 1197 admitted ICU or who needed invasive mechanical ventilation intubation hospital stay, more than 910 deaths. Primary outcomes were severity mortality main aim was evaluate association supplementation. Random effects models showed that associated significant lower both severe disease (SRR 0.38, 95% CI 0.20-0.72, 6 studies) 0.35, 0.17-0.70, 8 studies). There no statistically dose differences between studies: summary regular doses remain significant, suggesting higher are not necessary. For supplementation, greater reduction emerged older individuals latitudes. Regarding quality assessed using New Castle-Ottawa scale, analysis revealed most cases low, medium high studies. found associations Covid-19, encompassing risks worsening mortality, especially seasons characterized by patients. Dedicated randomized clinical studies encouraged confirm these results.

Язык: Английский

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