Effectiveness of COVID-19 vaccines against SARS-CoV-2 variants of concern in real-world: a literature review and meta-analysis

Emerging Microbes & Infections, Год журнала: 2022, Номер 11(1), С. 2383 - 2392

Опубликована: Сен. 7, 2022

Knowing vaccine effectiveness (VE) against variants of concern (VOCs) in the real-world setting is essential for public health decision-making. A systematic landscape VE a series clinical outcomes caused by VOCs needed. We systematically searched studies that evaluated and collected individual data. identified 113 meeting eligibility criteria. found full vaccination provided strong protection each outcome with summary ranging from 86.8% to 96.0% Alpha, moderate infection Beta, Gamma Delta 70.9% 72.8%, severe disease 84.9% 90.3%, limited 23.5% (95% CI, 17.0-29.5) 56.5% 82.4% diseases Omicron. Booster can provide substantial improvement Omicron, but not as much Delta. The meta-regression analysis showed Omicron wanned over time, hospitalization declined relatively slowly, compared infection. Those findings supported need measures, increasing booster coverage response current new infectious waves driven developing broadly protective vaccines confront virus evolution.

Язык: Английский

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Strong Correlations between the Binding Antibodies against Wild-Type and Neutralizing Antibodies against Omicron BA.1 and BA.2 Variants of SARS-CoV-2 in Individuals Following Booster (Third-Dose) Vaccination

Diagnostics, Год журнала: 2022, Номер 12(8), С. 1781 - 1781

Опубликована: Июль 22, 2022

This study examined the neutralizing activity and receptor-binding domain (RBD) antibody levels against wild-type omicron BA.1 BA.2 variants in individuals who received three doses of COVID-19 vaccination. The relationship between anti-RBD IgG live virus titers was examined. In total, 310 sera samples from after booster vaccination (third-dose) were tested for specific SARS-CoV-2 RBD surrogate neutralization test (sVNT). assay performed using foci-reduction (FRNT50). strongly correlated with FRNT50 BA.2. Non-linear regression showed that at cut-off value ≥148 BAU/mL ≥138 related to threshold ≥20 BA.2, respectively. A moderate correlation observed sVNT titers. At ≥20, predicted ≥10.57% ≥11.52%, identified predict detectable antibodies variants. Assessment monitoring protective immunity support vaccine policies will help identify optimal timing

Язык: Английский

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Long-Term Dynamic Changes in Hybrid Immunity over Six Months after Inactivated and Adenoviral Vector Vaccination in Individuals with Previous SARS-CoV-2 Infection

Vaccines, Год журнала: 2024, Номер 12(2), С. 180 - 180

Опубликована: Фев. 10, 2024

Numerous studies have largely focused on short-term immunogenicity in recovered individuals post mRNA vaccination. However, understanding the long-term durability, particularly inactivated and adenoviral vectored vaccines, remains limited. We evaluated antibody responses, omicron variant neutralization, IFN-γ responses 119 previously infected vaccinated with CoronaVac or ChAdOx1 up to six months post-vaccination. Both vaccines elicited robust immune individuals, surpassing those who were infection-naïve, these persisted above pre-vaccination levels for months. declined over time (geometric mean ratio (GMR) = 0.52 both vaccines). Notably, neutralizing activities against faster (GMR 0.6) compared recipients 1.03). While first dose of adequately induced a second demonstrated advantages neutralization slower decline. Although T cell median level at returned levels. more exhibited reactive responses. Extending interval (13–15 months) between infection vaccination could enhance broaden neutralization. Together, findings demonstrate humoral cellular response that was sustained least after vaccination, thus guiding optimal strategies based prior vaccine platforms.

Язык: Английский

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Safety and immunogenicity of a third dose of COVID-19 protein subunit vaccine (CovovaxTM) after homologous and heterologous two-dose regimens

International Journal of Infectious Diseases, Год журнала: 2022, Номер 126, С. 64 - 72

Опубликована: Ноя. 22, 2022

To report the safety and immunogenicity profile of a protein subunit vaccine (Covovax

Язык: Английский

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The type of the first prime/boost vaccine against SARS-CoV-2 exerts long-term effects on the humoral immune response

Clinical Immunology, Год журнала: 2025, Номер 278, С. 110523 - 110523

Опубликована: Май 15, 2025

The outbreak of COVID-19 spurred the development different vaccines against SARS-CoV-2 however, recommendations on how to maintain long-term protection from remain elusive. We here report a cohort 192 health care workers receiving their primary vaccination with either AZD1222 or BNT162b2. Over course three years, six blood samples were taken and analyzed for antibody dynamics receptor binding domain Spike protein function via surrogate virus neutralization. Our results showed that higher anti S titers correlated increased neutralizing capacity ameliorated disease. type first prime/boost vaccine exerted long term effects homologous BNT162b2 regimen outperforming in terms capacity. This deficit was not compensated by subsequent boosting RNA vaccines, still evident after is discussed context immune imprinting.

Язык: Английский

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Comparative duration of neutralizing responses and protections of COVID-19 vaccination and correlates of protection

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Май 22, 2025

The decline in neutralizing antibody (nAb) titers and vaccine efficacy /effectiveness (VE) for SARS-CoV-2 vaccines has been observed over time when confronted with emerging variants, two factors that are hard to distinguish. Despite substantial drop nAb against Omicron, VE remains high severe cases fatalities, raising questions about the utility of detected nAbs as a correlate protection COVID-19 varying disease severity. Here, we conducted systematic comparison waning dynamics variants levels Using Bayesian linear regression models, found antigenically-shifted like could potentially lead greater reductions primary mild infections than associated immunity 180-day period. By comparing model predicted on same scales, fatal outcomes remained above 75% even reached detectable limit assays, despite strong correlations (spearman ≥0.7) across time. This finding suggested not always sensitive enough fully predict death from SARS-CoV-2.

Язык: Английский

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The Fourth Dose of mRNA COVID-19 Vaccine Following 12 Different Three-Dose Regimens: Safety and Immunogenicity to Omicron BA.4/BA.5

Vaccines, Год журнала: 2023, Номер 11(3), С. 570 - 570

Опубликована: Март 1, 2023

The aim of this study is to investigate the reactogenicity and immunogenicity fourth dose using monovalent mRNA vaccines after different three-dose regimens compare 30 µg BNT162b2 50 mRNA-1273 vaccines. This prospective cohort was conducted between June October 2022. self-recorded evaluated on subsequent 7 days a dose. binding neutralizing activity antibodies against Omicron BA.4/5 variants were determined. Overall, 292 healthy adults enrolled received or mRNA-1273. Reactogenicity mild moderate well tolerated few days. Sixty-five individuals excluded. Thus, 227 eligible booster (n = 109) 118). Most participants, regardless type previous regimens, elicited significantly high level 28 (82.8%) (84.2%) groups comparable with median ratio 1.02. found that can be used as for who previously immunized any prior mix-and-match COVID-19 vaccine regimens.

Язык: Английский

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Pivoting to protein: the immunogenicity and safety of protein-based NVX-CoV2373 as a heterologous booster for inactivated and viral vector COVID-19 vaccines

Expert Review of Vaccines, Год журнала: 2023, Номер 22(1), С. 620 - 628

Опубликована: Июнь 30, 2023

Introduction Approximately half of the 13.4 billion COVID-19 vaccine doses administered globally were inactivated or viral vector platforms. The harmonization and optimization regimens has become a key focus policy makers healthcare providers presents an opportunity to reassess continued use pandemic-era vaccines.Areas covered Immunological evidence from studies various homologous heterologous been rapidly published, however interpretation these data are complicated by many types highly variable participant exposure vaccination histories. Recent demonstrate that after primary series (i.e. BBV152, BBIBP-CorV), (ChAdOx1 nCov-2019) vaccines, boost with protein-based NVX-CoV2373 elicits more potent ancestral strain omicron-specific antibody responses compared boosts.Expert opinion While mRNA vaccines likely yield similar performance booster doses, later offers notable advantages countries high uptake in terms transportation storage logistics can potentially appeal hesitant individuals. Moving forward, vaccine-mediated protection recipients may be optimized such as NVX-CoV2373.

Язык: Английский

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Immunogenicity and durability against Omicron BA.1, BA.2 and BA.4/5 variants at 3–4 months after a heterologous COVID-19 booster vaccine in healthy adults with a two-doses CoronaVac vaccination

Heliyon, Год журнала: 2023, Номер 10(1), С. e23892 - e23892

Опубликована: Дек. 20, 2023

Several countries have authorized a booster vaccine campaign to combat the spread of COVID-19. Data on persistence vaccine-induced immunity against new Omicron subvariants are still limited. Therefore, our study aimed determine serological immune response COVID-19 after CoronaVac-priming.

Язык: Английский

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Immunogenicity of the BNT162b2 COVID-19 vaccine as a third dose (booster) following two doses of different primary series regimens in Thailand

Pathogens and Global Health, Год журнала: 2022, Номер 116(7), С. 395 - 397

Опубликована: Авг. 3, 2022

Click to increase image sizeClick decrease size AcknowledgmentsWe would like thank the staff of Center Excellence in Clinical Virology and all participants for helping supporting this project. We also Ministry Public Health, Chulabhorn Royal Academy, Zuellig Pharma providing vaccines study.Disclosure statementAll authors have declared no competing interests.Additional informationFundingThis work was supported by National Research Council Thailand, Health Systems Institute, Chulalongkorn University, King Memorial Hospital, MK Restaurant Group, Second Century Fund Fellowship University.

Язык: Английский

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