Medicina, Год журнала: 2024, Номер 60(11), С. 1891 - 1891
Опубликована: Ноя. 18, 2024
: ATP-binding cassette (ABC) transporters are prominent drug targets due to their highly efficient trafficking capabilities and significant physiological clinical roles. Gaining insight into biophysical biomechanistic properties is crucial maximize pharmacological potential.
Язык: Английский
Frontiers in Immunology, Год журнала: 2025, Номер 15
Опубликована: Янв. 13, 2025
Background Subjects with immune-mediated inflammatory diseases (IMID), such as rheumatoid arthritis, tuberculosis infection (TBI), have a high probability of progressing to disease (TB). We aim characterize the impact IMID on immune response M. (Mtb) in patients TBI and TB disease. Methods enrolled without IMID. Peripheral blood mononuclear cells (PBMCs) were stimulated Mtb-derived epitopes (MTB300). By flow-cytometry, we identified Mtb-specific CD4 + T cytokine-producing or CD25 CD134 cells. Memory activation status assessed by evaluating: CD153, HLA-DR, CD45RA, CD27. Mycobacterial growth inhibition assay (MGIA) was used evaluate ability PBMCs inhibit mycobacteria growth. A long-term stimulation detect memory response. Results The therapy did not affect magnitude Mtb-antigen number responders. TBI-IMID showed cytokine profile like patients. Mtb characterized an effector central phenotype groups. This allowed increased IFN-γ production after 6 days MTB300-stimulation. HLA-DR expression associated TB, whereas CD153 status. Finally, had MGIA Conclusion condition does key aspects Mtb, response, profile, contain replication. immunological characterization fragile population is fundamental understanding correlation between protection
Язык: Английский
Процитировано
1
HOLISTIK JURNAL KESEHATAN, Год журнала: 2025, Номер 18(10), С. 1294 - 1301
Опубликована: Янв. 6, 2025
Background: Many Patient Pulmonary TB sufferers don’t comply with treatment because they feel bored. lasts quite a long time so that many drop out of and experience psychological problems. The importance strategies efforts to increase knowledge compliance the use technology. Purpose: To analyze differences in implementation psychoeducational model m-health application improving taking medication pulmonary tuberculosis patients. Method: research was carried using quantitative approach, true experimental design two control groups provision psychoeducation. Intervention group by providing applications. total sample size 140 participants, details 70 participants intervention at South Tangerang regional health center. Results: majority participants' education junior high school-high school graduates, there were 49 (70%) 46 (65.7%). Based on statistical tests, level p-value 0.000 <0.05. Conclusion: There is difference between group. has better than it uses application. Keywords: Application; Compliance; Knowledge; Psychoeducation; Tuberculosis. Pendahuluan: Banyak penderita (TB) paru yang tidak patuh terhadap pengobatan karena merasa jenuh. Pengobatan berlangsung cukup lama sehingga banyak putus berobat dan mengalami masalah psikologi. Pentingnya strategi upaya dengan peningkatan pengetahuan kepatuhan pemanfaatan teknologi. Tujuan: Untuk menganalisis perbedaan implementasi aplikasi psikoedukasi dalam minum obat pasien paru. Metode: Penelitian kuantitatif desain eksperiment menggunakan dua kelompok kontrol pemberian psikoedukasi. Kelompok intervensi Aplikasi Total jumlah sampel partisipan, rincian partisipan pada puskesmas wilayah Selatan. Hasil: Mayoritas pendidikan adalah lulusan SMP-SMA, sebanyak Berdasarkan uji statistik, terdapat tingkat Simpulan: Terdapat antara kontrol. memiliki lebih baik daripada Kata Kunci: Aplikasi; Kepatuhan; Pengetahuan; Psikoedukasi; Tuberculosis Paru.
Язык: Английский
Процитировано
0
Indian Journal of Immunology and Respiratory Medicine, Год журнала: 2024, Номер 9(1), С. 47 - 48
Опубликована: Апрель 15, 2024
Tuberculosis is a constant issue related to public health. The disease highly infectious, and about one-fourth of the global population presumed be infected. efforts for tuberculosis control are in full swing, especially endemic countries. World Day was celebrated on March 24, 2024; however, theme last year, i.e., 'Yes! We can end TB', continued 2024. justifies commitment stakeholders policymakers sustained effort eliminate tuberculosis.
Язык: Английский
Процитировано
3
Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, Год журнала: 2024, Номер 37, С. 100477 - 100477
Опубликована: Авг. 13, 2024
Multi-drug-resistant tuberculosis (MDR-TB) poses a significant public health challenge to the control and successful eradication of TB globally. Suboptimal treatment outcomes are common among persons with MDR-TB necessitating need understand contextual factors.
Язык: Английский
Процитировано
2
Scientific Reports, Год журнала: 2024, Номер 14(1)
Опубликована: Ноя. 28, 2024
Background: Distinguishing latent tuberculosis infection (LTBI) from active (ATB) is very important. This study aims to analyze cases multiple cohorts and get the signature that can distinguish LTBI ATB. Methods: Thirteen datasets were downloaded gene expression omnibus (GEO) database. Three selected as discovery datasets, hub genes discovered through WGCNA. In training cohort, we use machine learning establish signature, verify authentication ability of in remaining compare it with other signatures. Cluster analysis was carried out on ATB cases, immune cell infiltration analysis, GSVA drug sensitivity different clusters. Results: five genes. A (SLC26A8, ANKRD22, FCGR1B) obtained cohort. total three-gene separate (the area under ROC curve (AUC) 0.801, 95% CI 0.771–0.830). Compared author's signatures, our shows good identification ability. Immunological showed SLC26A8, FCGR1B closely related cells. According three genes, be divided into two clusters, which are set variation, sensitivity. Conclusion: Our produced an immune-related ATB, may help us manage treat patients.
Язык: Английский
Процитировано
2
JAC-Antimicrobial Resistance, Год журнала: 2024, Номер 6(4)
Опубликована: Июль 3, 2024
The emergence of drug resistance is a threat to global tuberculosis (TB) elimination goals. This study investigated the profiles
Язык: Английский
Процитировано
1
European Archives of Oto-Rhino-Laryngology, Год журнала: 2024, Номер 282(2), С. 743 - 751
Опубликована: Сен. 22, 2024
Язык: Английский
Процитировано
0
Sciences of Phytochemistry, Год журнала: 2024, Номер 3(2), С. 82 - 90
Опубликована: Сен. 5, 2024
Structural features of the triterpenoid skeleton that are necessary for antimycobacterial activity not well understood. Following isolation triterpenoids ergosterol-5,8-endoperoxide, 6β-hydroxykulactone, 12β-hydroxykulactone, (24R)-24,25-epoxycycloartan-3-one and (3β,24R)-24,25-epoxycycloartan-3-ol, (3β,24R)-24,25-epoxycycloartan-3-acetate with varying ranging between MIC 1 µg/ml to128 prompted us to study this class compounds further shade light on structural their activity. This in silico involved docking mycobacterial multi-pharmacophore receptor protein MmpL3. The results were compared MmpL3 co-crystallized TB drug candidate, AU1235, (1-(2-adamantyl)-3-[2,3,4-tris(fluoranyl)phenyl] urea). virtual screening revealed key skeleton, including C-3 keto β-hydroxy group or C-6, as important Also, decreased binding affinity 2 7 an acetate tandem those observed vitro. Toxicity predictions had no mutagenic effects displayed favorable pharmacokinetic parameters. reveals potential exemplified by readily available ergosterol-5,8-endoperoxide a useful scaffold searching developing effective therapeutic lead entities facilitate anti-tuberculosis discovery.
Язык: Английский
Процитировано
0
Revista da Associação Médica Brasileira, Год журнала: 2024, Номер 70(10)
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
0
Medicina, Год журнала: 2024, Номер 60(11), С. 1891 - 1891
Опубликована: Ноя. 18, 2024
: ATP-binding cassette (ABC) transporters are prominent drug targets due to their highly efficient trafficking capabilities and significant physiological clinical roles. Gaining insight into biophysical biomechanistic properties is crucial maximize pharmacological potential.
Язык: Английский
Процитировано
0