Epidemic after pandemic: Dengue surpasses COVID-19 in number of deaths
Pulmonology,
Год журнала:
2025,
Номер
31(1)
Опубликована: Янв. 7, 2025
Язык: Английский
Latin America’s Dengue Outbreak Poses a Global Health Threat
Viruses,
Год журнала:
2025,
Номер
17(1), С. 57 - 57
Опубликована: Янв. 1, 2025
Dengue
fever,
caused
by
the
dengue
virus
(DENV),
poses
a
significant
global
health
challenge,
particularly
in
tropical
and
subtropical
regions.
Recent
increases
indigenous
DENV
cases
Europe
are
concerning,
reflecting
rising
incidence
linked
to
climate
change
spread
of
Aedes
albopictus
mosquitoes.
These
vectors
thrive
under
environmental
conditions
like
temperature
humidity,
which
increasingly
influenced
change.
Additionally,
travel
accelerates
cross-border
mosquito-borne
diseases.
manifests
clinically
spectrum
from
asymptomatic
severe
hemorrhagic
fever
shock
syndrome,
viral
serotype
host
factors.
In
2024,
Brazil
experienced
fourfold
increase
compared
2023,
accompanied
higher
mortality.
Conventional
control
measures,
such
as
vector
control,
community
engagement,
vaccination,
proved
insufficient
exacerbated
mosquito
proliferation,
challenging
containment
efforts.
this
regard,
our
review
analyzes
prevention
measures
therapeutic
protocols
during
outbreak
while
addressing
transmission
dynamics,
clinical
presentations,
epidemiological
shifts.
It
also
evaluates
diagnostic
strategies
combining
assessment
with
serological
molecular
testing,
providing
information
improve
preventive
measures.
The
expansion
dengue-endemic
regions,
including
outbreaks
Europe,
highlights
urgent
need
for
enhanced
surveillance,
proactive
interventions,
international
collaboration
mitigate
growing
threat
other
arboviruses
West
Nile,
Zika,
Chikungunya,
Oropouche,
Yellow
Fever
viruses.
Язык: Английский
Efficacy of Ivermectin, Chloroquine/Hydroxychloroquine, and Azithromycin in Managing COVID-19: A Systematic Review of Phase III Clinical Trials
Biomedicines,
Год журнала:
2024,
Номер
12(10), С. 2206 - 2206
Опубликована: Сен. 27, 2024
During
the
coronavirus
disease
(COVID)-19
pandemic
several
drugs
were
used
to
manage
patients
mainly
those
with
a
severe
phenotype.
Potential
off-label
and
major
concerns
arose
from
their
applicability
managing
health
crisis
highlighting
importance
of
clinical
trials.
In
this
context,
we
described
mechanisms
three
repurposed
[Ivermectin-antiparasitic
drug,
Chloroquine/Hydroxychloroquine-antimalarial
drugs,
Azithromycin-antimicrobial
drug];
and,
based
on
description,
study
evaluated
efficacy
published
in
The
use
these
reflects
period
uncertainty
that
marked
beginning
COVID-19
pandemic,
which
made
them
possible
treatment
for
COVID-19.
Язык: Английский
The role of weather and city environment in dengue outbreaks: what do we know so far?
OBSERVATÓRIO DE LA ECONOMÍA LATINOAMERICANA,
Год журнала:
2025,
Номер
23(1), С. e8564 - e8564
Опубликована: Янв. 7, 2025
Dengue
fever,
a
mosquito-borne
viral
infection
caused
by
the
dengue
virus
(DENV)
and
primarily
transmitted
Aedes
aegypti,
poses
growing
global
health
economic
burden.
The
disease's
spread
has
intensified
due
to
rapid
urbanization,
globalization,
inadequate
vector
control,
climate
variability.
recent
2024
epidemic
in
Latin
America,
exacerbated
El
Niño-associated
climatic
changes,
underscores
critical
role
of
socio-economic
environmental
factors
transmission.
This
review
examines
interplay
between
these
determinants,
highlighting
vulnerabilities,
human
mobility
as
key
contributors.
Poorly
planned
urbanization
low-income
housing
conditions
increase
mosquito
breeding
habitats,
while
drives
peri-urban
rural
areas.
Climatic
factors,
including
temperature,
rainfall,
humidity,
directly
influence
biology
propagation,
with
urban
heat
islands
seasonal
monsoons
amplifying
transmission
dynamics.
interaction
further
exacerbates
risks,
particularly
densely
populated,
areas
sanitation
healthcare
access.
Effective
interventions
must
integrate
land-use
planning
sustainable
designs
reduce
sites,
coupled
strategies
address
vulnerabilities
adapt
change.
These
findings
offer
insights
for
policymakers
allocate
resources
implement
targeted
prevention
control
measures.
Язык: Английский
The Oropouche fever in Latin America: a hidden threat and a possible cause of microcephaly due to vertical transmission
Frontiers in Public Health,
Год журнала:
2025,
Номер
13
Опубликована: Март 26, 2025
Dear
Editor,
Latin
America
(LATAM)
is
facing
a
severe
outbreak
of
arbovirus,
particularly
Dengue
fever
(Boschiero
et
al.,
2023;
Sansone
2024a).
In
addition,
the
cases
Oropouche
(OF),
zoonotic
disease
caused
by
virus
(OROV),
are
increasing
(Sansone
2024b).
The
OROV
member
Bunyaviridae
family.
Its
viral
genome
composed
three
segments
negative-sense
single-stranded
ribonucleic
acid
(RNA).
Previous
outbreaks
described
between
2022
and
2024
were
associated
with
rearrangements
resulting
in
reassortant
virus,
genomic
from
different
previously
circulating
strains
(Azevedo
2024;
Moreira
2024).
Also,
there
description
rearrangement
Iquitos
that
also
classified
Orthobunyavirus
oropoucheense
species
—
included
other
species:
Madre
de
Dios
Oropouche-like
Perdoes
Transmitted
mainly
Culicoides
paraensis
midge,
OF
can
spread
through
arthropods
such
as
Aedes
serratus,
Culex
quinquefasciatus,
Coquillettidia
venezuelensis
(Martins-Filho
Zhang
First
identified
Trinidad
Tobago
1950s
endemic
to
Amazon
region
extends
umpteen
Central
South
American
countries
As
18th
epidemiological
week
2024,
LATAM
reported
5193
OF,
Brazil
accounting
for
4583
(88.3%)
Pan
Health
Organization.
Recent
data
Brazilian
Ministry
show
dramatic
increase
6976
26th
week,
up
839.5%
831
2023
(Figs.
1a,
1b;
Fig.
2).
According
recent
study,
has
been
detected
all
26
states
contrast
which
most
Cerrado
regions.
Small
medium
municipalities
non-Amazon
especially
affected,
frequency
3
9
times
higher
compared
large
(Gräf
Please
see
complete
Graph
Abstract
presented
Supplementary
Material
Presentation
1
Table
1.
non-endemic
regions
extra-Amazonian
where
autochthonous
have
(Fig.
1c),
factors
global
warming,
deforestation,
flooding
may
exacerbate
mosquito-borne
modulating
life
cycle
mosquitoes
spreading
their
proliferation
Sah
it
utmost
importance
screen
rearrangements;
arboviruses'
pandemics
human
outbreaks.
symptoms
similar
those
arboviruses
dengue
chikungunya,
complicating
diagnosis,
routine
laboratory
tests
scarce
Most
self-limiting,
but
serious
complications
meningitis
encephalitis
occur
2024).OF
lead
neurological
issues
(Zhang
2024),
only
Zika
definitively
linked
microcephaly
vertical
transmission
(Vaziri
2022).
On
July
11th,
recommended
increased
surveillance
(Nota
Técnica
no
6/2024-CGARB/DEDT/SVSA/MS
Ministério
da
Saúde,
n.d.).
Evandro
Chagas
Institute
found
Immunoglobulin
M
(IgM)
antibodies
serum
cerebrospinal
fluid
samples
four
newborns
who
tested
negative
(Dengue,
Chikungunya,
Zika,
West
Nile
virus)
15/2024-SVSA/MS
Although
exact
link
not
yet
clear,
findings
include
case
fetal
death
at
30
weeks
organs,
suggesting
potential
n.d.).In
addition
this
discovery,
researchers
traced
series
they
evaluated
infants
infectious
diseases
congenital
malformations,
arthrogryposis,
respective
mothers
presence
against
OROV.
A
total
68
collected:
65
historical
2024.
Of
these,
6
(8.8%)
exhibited
positive
immunoglobulin
reaction
cerebral
spinal
(6
cases);
4
IgM
too.
newborn
OROV,
one
age
44
days
had
an
identification
RNA
real-time-quantitative
polymerase
chain
analysis
fluid.
Moreover,
patient
died
47
pleural
tissues
brain,
kidney,
lungs.
particular
case,
several
modifications
brain
macroscopically
microscopically
described,
including
necrotic
apoptotic
changes
neurons,
microglia
astrocytes,
vacuolization,
tissue
atrophy
(das
Neves
Martins
intensifying
pregnancies
suspected
arbovirus
infections.
This
includes
monitoring
abortions,
deaths,
collecting
relevant
biological
samples.
For
protection,
pregnant
women
should
avoid
areas
prone
insects,
use
fine
mesh
screens,
wear
protective
clothing,
apply
repellent,
keep
homes
clean,
follow
local
health
guidelines
if
confirmed
area
(Oropouche:
Cases
mother-to-child
under
investigation
-
PAHO/WHO
|
Organization,
Nota
n.d.).Because
emerging
order
deal
cases,
crucial
control
mosquito
identify
breeding
sites
public
agents
governments
collaborate
on
policies
promote
education
better
diagnosis
prevention.
These
efforts
could
manage
outbreaks,
mitigate
individual
impact,
protect
travelers
areas.
Continued
research
essential
understand
relationship.
However,
measures
taken
contain
any
need
continuous
note
possible
optimize
diagnostic
methods.
latter
currently
still
depend
complex
machinery,
developing
countries,
thus
avoiding
underreporting.
Finally,
cohort
studies,
prospective
ones,
larger
samples,
assess
long-term
affected
individuals
babies
be
born
or
complications.
Язык: Английский
Pulmonary and functional hallmarks after SARS-CoV-2 infection across three WHO severity level-groups: an observational study
Frontiers in Medicine,
Год журнала:
2025,
Номер
12
Опубликована: Апрель 7, 2025
The
manifestations
of
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
infection
range
from
flu-like
symptoms
to
lung
disease.
consequences
this
inflammatory
process
impact
overall
function,
which
can
be
detected
through
both
short-
long-term
assessments.
This
study
aimed
assess
the
pulmonary
functional
and
structural
characteristics
post-SARS-CoV-2
in
patients
with
mild/moderate,
severe,
critical
clinical
presentations.
An
observational,
analytical,
cross-sectional
was
conducted
between
2020
2022,
including
participants
a
confirmed
diagnosis
disease
(COVID)-19,
mild/moderate
(G1),
(G2),
(G3)
presentations,
all
evaluated
at
least
3
months
after
infection.
Spirometry,
impulse
oscillometry,
fractional
exhaled
nitric
oxide
(FeNO),
chest
computed
tomography,
6-min
walk
test
(6MWT),
hand
grip
strength,
maximum
inspiratory
pressure,
expiratory
pressure
were
assessed.
We
enrolled
210
aged
18-70
years,
32.6%
whom
male,
older
age
observed
G3.
grouped
as
follows:
G1
(42.3%),
G2
(25.7%),
G3
(31.9%).
Percentage
predicted
X5
differed
G2,
being
higher
G1.
percentage
forced
vital
capacity
(FVC)
according
Global
Lung
Function
Initiative
its
z-score
FVC
by
Pereira
lower
compared
volume
1
s
(FEV1)
also
Tiffeneau
(FEV1/FVC)
index
different
among
groups,
increasing
severity.
flow
rate
25-75%
(FEF25-75%)
FeNO
than
Chest
tomography
revealed
presence
interstitial
abnormalities,
associated
muscle
strength
evaluation
showed
an
association
values
G1,
but
no
observed.
6MWT
distance
covered
decreased
severity,
right-hand
Alterations
markers
post-COVID-19
evaluations,
seen
These
findings
highlight
complexity
assessments,
given
sequelae
consequent
impairment
capacity.
Язык: Английский
Impact of Climate Change on Transmission Patterns of Infectious Diseases and Public Health Responses
Highlights in Science Engineering and Technology,
Год журнала:
2024,
Номер
123, С. 71 - 76
Опубликована: Дек. 24, 2024
Global
warming
has
expanded
the
transmission
range
of
some
pathogens
and
disease
vectors
(such
as
mosquitoes)
that
initially
lived
in
tropical
or
subtropical
regions,
increasing
their
chances
transmission.
This
change
increases
risk
spread
infectious
diseases,
such
dengue
fever,
malaria
cholera.
These
diseases
have
caused
a
huge
impact
harm
to
human
health.
Therefore,
this
article
analyzes
summarizes
academic
research
articles
study
changes
ways,
why
these
are
affected
by
climate
influence
public
health
measures,
through
topic
also
can
clearly
know
how
will
make
pathogen
life
cycle
route,
expand
media
activities,
finally
should
strengthen
monitoring
early
warning
system,
promote
international
cooperation,
improve
facilities
environmental
targeted
control
strategies,
education
propaganda.
Язык: Английский