Re: “COVID-19, mucormycosis, and the cow: Damned lies!”

Indian Journal of Medical Microbiology, Год журнала: 2023, Номер 46, С. 100462 - 100462

Опубликована: Сен. 1, 2023

Язык: Английский

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Pathogenesis of COVID-19-Associated Mucormycosis: An Updated Evidence-Based Review

Current Fungal Infection Reports, Год журнала: 2024, Номер 18(1), С. 69 - 75

Опубликована: Фев. 1, 2024

Язык: Английский

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Association of COVID with Mycosis in General

Infectious Disorders - Drug Targets, Год журнала: 2024, Номер 24(6)

Опубликована: Янв. 22, 2024

Background: The COVID-19 pandemic caused by SARS-CoV-2 is a respiratory disease which created havoc worldwide, was accompanied another peculiar, otherwise rare, secondary fungal infection Mucormycosis observed at exceptionally high incidence in India during the second wave of COVID-19. article explores possible links between two infectious diseases to understand higher-than-normal occurrence patients. Coronavirus enters patients through ACE-2 and many other receptors like- NRP-1, TfR, CD-126, CD-26. Virus bind cells possessing these affect their proper functioning, disturbing homeostatic metabolism resulting conditions like hyperglycemia, Diabetic Ketoacidosis (DKA), low serum pH, iron overload, anemia, hypoxia, immunosuppression as explained article. All outcomes provide very supportive environment for attack spread fungi. major receptor humans GRP-78. Its expression upregulated coronavirus entry hyperferritinemia, acidic prevalent COVID patients, thus providing an easy species. Upregulation GRP-78 furthermore damages pancreatic β-cells intensifies showing quite synergic relationship. Inordinate rise cases might be facts large proportion diabetic emergence deadly strain coronavirus- Delta strain, higher doses steroids antibodies used treat against this overburdened health care services, sudden much need oxygen supply use industrial could explain outbreak Objective: present review discusses functional interdependence summarizes Mucormycosis. Conclusion: metabolic pathways affected result severe physiological conditions- DKA, immunosuppression, hypoxia. not only increase GRP-78, fungi but also play crucial role quality media fungus establish grow. Hence explains epidemic India.

Язык: Английский

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Cow dung, COVID-19, and mucormycosis … more damned lies

Indian Journal of Medical Microbiology, Год журнала: 2023, Номер 46, С. 100464 - 100464

Опубликована: Сен. 8, 2023

Язык: Английский

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