Nanotechnology’s frontier in combatting infectious and inflammatory diseases: prevention and treatment

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Фев. 21, 2024

Abstract Inflammation-associated diseases encompass a range of infectious and non-infectious inflammatory diseases, which continuously pose one the most serious threats to human health, attributed factors such as emergence new pathogens, increasing drug resistance, changes in living environments lifestyles, aging population. Despite rapid advancements mechanistic research development for these current treatments often have limited efficacy notable side effects, necessitating more effective targeted anti-inflammatory therapies. In recent years, nanotechnology has provided crucial technological support prevention, treatment, detection inflammation-associated diseases. Various types nanoparticles (NPs) play significant roles, serving vaccine vehicles enhance immunogenicity carriers improve targeting bioavailability. NPs can also directly combat pathogens inflammation. addition, facilitated biosensors pathogen imaging techniques This review categorizes characterizes different NPs, summarizes their applications It discusses challenges associated with clinical translation this field explores latest developments prospects. conclusion, opens up possibilities comprehensive management

Язык: Английский

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Nanomaterials and Their Impact on the Immune System

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(3), С. 2008 - 2008

Опубликована: Янв. 19, 2023

Nanomaterials have been the focus of intensive development and research in medical industrial sectors over past several decades. Some studies found that these compounds can a detrimental impact on living organisms, including their cellular components. Despite obvious advantages using nanomaterials wide range applications, there is sometimes skepticism caused by lack substantial proof evaluates potential toxicities. The interactions nanoparticles (NPs) with cells immune system biomolecule pathways are an area interest for researchers. It possible to modify NPs so they not recognized or suppress stimulate targeted manner. In this review, we look at literature immunostimulation immunosuppression how changing physicochemical features particles could alter better worse (immunotoxicity). We also into whether unique unexpected (but desired) effect system, surface grafting polymers coatings makes stealth cannot find get rid of.

Язык: Английский

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Review of Advances in Coating and Functionalization of Gold Nanoparticles: From Theory to Biomedical Application

Pharmaceutics, Год журнала: 2024, Номер 16(2), С. 255 - 255

Опубликована: Фев. 9, 2024

Nanoparticles, especially gold nanoparticles (Au NPs) have gained increasing interest in biomedical applications. Used for disease prevention, diagnosis and therapies, its significant advantages therapeutic efficacy safety been the main target of interest. Its application immune system stability physiological environments cell membranes, low toxicity optimal bioperformances are critical to success engineered nanomaterials. unique optical properties great attractors. Recently, several physical chemical methods coating these NPs widely used. Biomolecules such as DNA, RNA, peptides, antibodies, proteins, carbohydrates biopolymers, among others, used coatings Au various applications, thus their biocompatibility while maintaining biological functions. This review mainly presents a general representative view different types NP functionalization using biomolecules, strategies mechanisms.

Язык: Английский

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Review of Gold Nanoparticles: Synthesis, Properties, Shapes, Cellular Uptake, Targeting, Release Mechanisms and Applications in Drug Delivery and Therapy

Pharmaceutics, Год журнала: 2024, Номер 16(10), С. 1332 - 1332

Опубликована: Окт. 16, 2024

The remarkable versatility of gold nanoparticles (AuNPs) makes them innovative agents across various fields, including drug delivery, biosensing, catalysis, bioimaging, and vaccine development. This paper provides a detailed review the important role AuNPs in delivery therapeutics. We begin by exploring traditional systems (DDS), highlighting revolutionizing techniques. then describe unique intriguing properties that make exceptional for delivery. Their shapes, functionalization, drug-loading bonds, targeting mechanisms, release therapeutic effects, cellular uptake methods are discussed, along with relevant examples from literature. Lastly, we present applications medical domains, cancer, cardiovascular diseases, ocular diabetes, focus on vitro vivo cancer research.

Язык: Английский

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Hemolytic Activity of Nanoparticles as a Marker of Their Hemocompatibility

Micromachines, Год журнала: 2022, Номер 13(12), С. 2091 - 2091

Опубликована: Ноя. 27, 2022

The potential use of nanomaterials in medicine offers opportunities for novel therapeutic approaches to treating complex disorders. For that reason, a new branch science, named nanotoxicology, which aims study the dangerous effects on human health and environment, has recently emerged. However, toxicity risk associated with are unclear or not completely understood. development an adequate experimental strategy assessing may include rapid/express method will reliably, quickly, cheaply make initial assessment. One possibility is characterization hemocompatibility nanomaterials, includes their hemolytic activity as marker. In this review, we consider various factors affecting draw reader’s attention fact formation protein corona around nanoparticle can significantly change its interaction red cell. This leads us suggest nanomaterial buffer does reflect situation blood plasma. As recommendation, propose studying under more physiologically relevant conditions, presence plasma proteins medium mechanical stress.

Язык: Английский

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Recent Metal Nanotheranostics for Cancer Diagnosis and Therapy: A Review

Diagnostics, Год журнала: 2023, Номер 13(5), С. 833 - 833

Опубликована: Фев. 22, 2023

In recent years, there has been an increasing interest in using nanoparticles the medical sciences. Today, metal have many applications medicine for tumor visualization, drug delivery, and early diagnosis, with different modalities such as X-ray imaging, computed tomography (CT), magnetic resonance imaging (MRI), positron emission (PET), etc., treatment radiation. This paper reviews findings of nanotheranostics therapy. The study offers some critical insights into types cancer detection purposes. data this review were gathered from multiple scientific citation websites Google Scholar, PubMed, Scopus, Web Science up through end January 2023. literature, are used applications. However, due to their high abundance, low price, performance visualization treatment, gold, bismuth, tungsten, tantalum, ytterbium, gadolinium, silver, iron, platinum, lead investigated study. highlighted importance iron-based forms ease functionalization, toxicity, superior biocompatibility.

Язык: Английский

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Shape dependent protein‐induced stabilization of gold nanoparticles: From a protein corona perspective

Aggregate, Год журнала: 2023, Номер 4(4)

Опубликована: Фев. 22, 2023

Abstract Gold nanoparticles (AuNPs) are promising materials for many bioapplications. However, upon contacting with biological media, AuNPs undergo changes. The interaction proteins results in the so‐called protein corona (PC) around AuNPs, leading to new bioidentity and optical properties. Understanding mechanisms of PC formation its functions can help us utilise benefits avoid drawbacks. To date, most previous works aimed understand governing focused on spherical nanoparticles, although non‐spherical designed a wide range applications biosensing. In this work, we investigated differences anisotropic (nanostars particular) from joint experimental (extinction spectroscopy, zeta potential surface‐enhanced Raman scattering [SERS]) computational methods (the finite element method molecular dynamics [MD] simulations). We discovered that does not fully cover surface leaving SERS hot‐spots at tips high curvature edges ‘available’ analyte binding (no signal after pre‐incubation protein) while providing protein‐induced stabilization (indicated by extinction spectroscopy) layer particle's core. findings confirmed our MD simulations, adsorption energy significantly decreases increased radius curvature, so (adsorption energy: 2762.334 kJ/mol) would be least preferential site compared core 11819.263 kJ/mol). These observations will development nanostructures improved sensing targeting ability.

Язык: Английский

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Confronting antifungal resistance, tolerance, and persistence: Advances in drug target discovery and delivery systems

Advanced Drug Delivery Reviews, Год журнала: 2023, Номер 200, С. 115007 - 115007

Опубликована: Июль 16, 2023

Язык: Английский

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Zebrafish Insights into Nanomaterial Toxicity: A Focused Exploration on Metallic, Metal Oxide, Semiconductor, and Mixed-Metal Nanoparticles

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(3), С. 1926 - 1926

Опубликована: Фев. 5, 2024

Nanomaterials are widely used in various fields, and ongoing research is focused on developing safe sustainable nanomaterials. Using zebrafish as a model organism for studying the potentially toxic effects of nanomaterials highlights importance Studies conducted their toxicity potential risks to human environmental health vital biomedical sciences. In present review, we discuss (inorganic organic) exposure based size, shape, concentration. The review further explores types impacts at different levels, indicating that can lead developmental defects, changes gene expressions, toxicities. also covers considering natural organic matter chorion membranes standardized nanotoxicity testing. While some biologically compatible, metal semiconductor enter water environment increase aquatic creatures accumulate body. Further investigations necessary assess safety health.

Язык: Английский

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Nanotechnology as a Promising Method in the Treatment of Skin Cancer

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(4), С. 2165 - 2165

Опубликована: Фев. 10, 2024

The incidence of skin cancer continues to grow. There are an estimated 1.5 million new cases each year, which nearly 350,000 melanoma, is often fatal. Treatment challenging and ineffective, with conventional chemotherapy playing a limited role in this context. These disadvantages can be overcome by the use nanoparticles may allow for early detection monitoring neoplastic changes determining effectiveness treatment. This article briefly reviews present understanding characteristics cancers, their epidemiology, risk factors. It also outlines possibilities using nanotechnology, especially nanoparticles, transport medicinal substances. Research over previous decade on carriers active substances indicates that drugs delivered more accurately tumor site, resulting higher therapeutic efficacy. describes application liposomes, carbon nanotubes, metal polymer existing therapies. discusses challenges encountered nanoparticle therapy improving performance. Undoubtedly, promising method help fight against cancer.

Язык: Английский

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