Drug administration via feeding tubes—a procedure that carries risks: systematic identification of critical factors based on commonly administered drugs in a cohort of stroke patients DOI Creative Commons
Jana Sommerfeldt,

H Sartorius,

Bettina von Sarnowski

и другие.

European Journal of Clinical Pharmacology, Год журнала: 2024, Номер 80(11), С. 1599 - 1623

Опубликована: Июль 29, 2024

Abstract Purpose Drug administration via feeding tubes is considered a process with many uncertainties. This review aimed to give comprehensive overview of data available on tube application and carry out risk assessments for drug substances commonly administered stroke patients. Methods Drugs frequently were identified through retrospective analysis discharge letters from unit. Physicochemical, pharmacokinetic, stability properties these drugs drug-enteral nutrition interactions systematically searched in the European Pharmacopoeia, Hagers Handbook Pharmaceutical Practice, Birchers clinical-pharmacological compilation, Martindale Complete Reference, as well databases including DrugBank, DrugDex, PubChem, Google Scholar, PubMed. Results Of most present patient cohort, bisoprolol, candesartan, ramipril could be least critical due their overall favourable properties. Acetylsalicylic acid, amlodipine, hydrochlorothiazide, omeprazole esomeprazole, simvastatin, torasemide pose risks based pH or light-dependent instability proposed food effects. The are furosemide, levodopa, levothyroxine they show relevant instabilities under conditions substantial effects; latter two even possess narrow therapeutic index. However, little information drug-tube drug-formula interactions. Conclusion Feeding medications turned highly complex several unmet risks. Therefore, investigations that assess factors using clinically model systems urgently needed.

Язык: Английский

Drug administration via feeding tubes—a procedure that carries risks: systematic identification of critical factors based on commonly administered drugs in a cohort of stroke patients DOI Creative Commons
Jana Sommerfeldt,

H Sartorius,

Bettina von Sarnowski

и другие.

European Journal of Clinical Pharmacology, Год журнала: 2024, Номер 80(11), С. 1599 - 1623

Опубликована: Июль 29, 2024

Abstract Purpose Drug administration via feeding tubes is considered a process with many uncertainties. This review aimed to give comprehensive overview of data available on tube application and carry out risk assessments for drug substances commonly administered stroke patients. Methods Drugs frequently were identified through retrospective analysis discharge letters from unit. Physicochemical, pharmacokinetic, stability properties these drugs drug-enteral nutrition interactions systematically searched in the European Pharmacopoeia, Hagers Handbook Pharmaceutical Practice, Birchers clinical-pharmacological compilation, Martindale Complete Reference, as well databases including DrugBank, DrugDex, PubChem, Google Scholar, PubMed. Results Of most present patient cohort, bisoprolol, candesartan, ramipril could be least critical due their overall favourable properties. Acetylsalicylic acid, amlodipine, hydrochlorothiazide, omeprazole esomeprazole, simvastatin, torasemide pose risks based pH or light-dependent instability proposed food effects. The are furosemide, levodopa, levothyroxine they show relevant instabilities under conditions substantial effects; latter two even possess narrow therapeutic index. However, little information drug-tube drug-formula interactions. Conclusion Feeding medications turned highly complex several unmet risks. Therefore, investigations that assess factors using clinically model systems urgently needed.

Язык: Английский

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