Current Pharmaceutical Design,
Год журнала:
2024,
Номер
31(4), С. 244 - 260
Опубликована: Апрель 30, 2024
In
recent
years,
advancements
in
chemistry
have
allowed
the
tailoring
of
materials
at
nanoscopic
level
as
needed.
There
are
mainly
four
main
types
nanomaterials
used
drug
carriers:metal-based
nanomaterials,
organic
inorganic
and
polymer
nanomaterials.
The
a
carrier
showed
advantages
for
decreased
side
effects
with
higher
therapeutic
index.
stability
compounds
increased
by
encapsulation
within
nano-drug
carriers,
leading
to
systemic
toxicity.
Nano-drug
carriers
also
controlled
release
system-made
solubility
characteristics
nanoparticles
surface
coating
surfactants.
review
focuses
on
different
nanoparticle
synthesis
process,
techniques
purposes,
applications
prospects
biomedical
applications.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Июль 19, 2024
Abstract
Colorectal
cancer,
the
third
most
prevalent
cancer
globally,
contributes
significantly
to
mortality
rates,
with
over
1.9
million
reported
cases
and
nearly
935,000
fatalities
annually.
Surgical
resection
is
a
primary
approach
for
localized
colorectal
tumors,
adjunct
therapies
like
chemotherapy,
radiotherapy,
targeted/immunotherapy
considered
depending
on
tumor
stage.
However,
despite
preferences
targeted
immunotherapy
post-surgery,
chemotherapy
remains
commonly
chosen
due
its
lower
cost
high
cancer-killing
efficiency.
Yet,
faces
issues
such
as
resistance
severe
side
effects.
Nanotechnology
has
emerged
in
therapy
by
alleviating
drawbacks
of
current
treatment
approaches.
In
past
few
decades,
inorganic
nanoparticles
have
shown
promise
combating
offering
advantages
conventional
chemotherapy.
Compared
organic
nanoparticles,
exhibit
properties
photosensitivity,
conductivity,
magnetic
allure,
thermal
proficiency,
allowing
them
function
both
drug
carriers
therapeutic
agents.
Derived
primarily
from
carbon,
silica,
metals,
metal
oxides,
they
offer
superior
drug-loading
capacity,
heightened
quantum
yield,
participation
advanced
photothermal
photodynamic
therapies.
This
review
provides
brief
overview
pathophysiology
pivotal
role
therapy,
delivery.
Additionally,
it
discusses
numerous
based
recent
literature.
Graphical
abstract
Polymers,
Год журнала:
2024,
Номер
16(6), С. 843 - 843
Опубликована: Март 19, 2024
Chemotherapy
together
with
surgery
and/or
radiotherapy
are
the
most
common
therapeutic
methods
for
treating
cancer.
However,
off-target
effects
of
chemotherapy
known
to
produce
side
and
dose-limiting
toxicities.
Novel
delivery
platforms
based
on
natural
synthetic
polymers
enhanced
pharmacokinetic
potential
treatment
cancer
have
grown
tremendously
over
past
10
years.
Polymers
can
facilitate
selective
targeting,
enhance
prolong
circulation,
improve
delivery,
provide
controlled
release
cargos
through
various
mechanisms,
including
physical
adsorption,
chemical
conjugation,
internal
loading.
Notably,
that
biodegradable,
biocompatible,
physicochemically
stable
considered
be
ideal
carriers.
This
biomimetic
bio-inspired
system
offers
a
bright
future
effective
drug
overcome
obstacles
encountered.
review
focuses
barriers
impact
success
as
well
recent
developments
improving
Advanced Functional Materials,
Год журнала:
2023,
Номер
34(7)
Опубликована: Окт. 31, 2023
Abstract
Nanosponges
are
unique
sponge‐like
carrier
systems
with
numerous
cavities
and
a
mesh‐like
network
throughout
their
surface.
They
categorized
into
three
types
based
on
the
material
of
construction,
i.e.,
polymer‐,
inorganic‐,
bio‐derived
material‐based
nanosponges.
Unlike
conventional
nanoparticles,
nanosponges
bear
countless
interconnected
voids
that
enables
maximum
drug,
imaging
probe,
or
photosensitizer
loading
via
absorption,
encapsulation,
conjugation,
complexion.
The
can
be
further
sealed
using
suitable
lipids
polymers
to
avoid
leakage
drugs
at
non‐target
site,
protect
therapeutics
from
biological
conditions,
control
release
for
prolonged
period.
Recently,
have
grasped
attention
researchers
in
area
cancer
by
overcoming
drawbacks
associated
delivery
immunotherapeutic,
targeted
therapeutic,
chemotherapeutic
agents.
Interestingly,
several
reports
also
witnessed
potential
theranostics.
Owing
this
supremacy,
could
an
apt
platform
therapy
diagnosis.
current
review
discusses
general
aspects,
types,
preparation
methods
In
addition,
ambit
treating
different
is
meticulously
discussed,
along
detailed
descriptions
corresponding
patents.
Furthermore,
role
phototherapy
theranostics
selectively
canvassed.
