Topical drug delivery strategies for enhancing drug effectiveness by skin barriers, drug delivery systems and individualized dosing

Frontiers in Pharmacology, Год журнала: 2024, Номер 14

Опубликована: Янв. 16, 2024

Topical drug delivery is widely used in various diseases because of the advantages not passing through gastrointestinal tract, avoiding irritation and hepatic first-pass effect, reaching lesion directly to reduce unnecessary adverse reactions. The skin helps organism defend itself against a huge majority external aggressions one most important lines defense body. However, skin’s strong barrier ability also obstacle effectiveness topical medications. Allowing bioactive, composition pass stratum corneum as needed reach target site essential need for exert its therapeutic effect. state barrier, choice system composition, individualized disease detection dosing planning influence Nowadays, enhancing transdermal absorption topically applied drugs hottest research area. first improve all drugs. Excessive enhances accumulation at non-target sites occurrence This paper introduces strategies from three perspectives: delivery, describes current status shortcomings research, provides new directions ideas research.

Язык: Английский

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Block copolymer micelles as ocular drug delivery systems

Drug Discovery Today, Год журнала: 2024, Номер 29(8), С. 104098 - 104098

Опубликована: Июль 10, 2024

Block copolymer micelles, formed by the self-assembly of amphiphilic polymers, address formulation challenges, such as poor drug solubility and permeability. These micelles offer advantages including a smaller size, easier preparation, sterilization, superior solubilization, compared with other nanocarriers. Preclinical studies have shown promising results, advancing them toward clinical trials. Their mucoadhesive properties enhance prolong contact ocular surface, their small size allows deeper penetration through tissues, cornea. Additionally, copolymeric improve stability hydrophobic drugs, sustain release, allow for surface modifications to biocompatibility. Despite these benefits, long-term remains challenge. In this review, we highlight preclinical performance, structural frameworks, preparation techniques, physicochemical properties, current developments, prospects block delivery systems.

Язык: Английский

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An Up-to-Date Overview of Liquid Crystals and Liquid Crystal Polymers for Different Applications: A Review

Polymers, Год журнала: 2024, Номер 16(16), С. 2293 - 2293

Опубликована: Авг. 14, 2024

Liquid crystals have been extensively used in various applications, such as optoelectronic devices, biomedical sensors and biosensors, packaging, among others. crystal polymers are one type of liquid material, combining their intrinsic properties with polymeric flexibility for advanced applications displays smart materials. For instance, can serve drug nanocarriers, forming cubic or hexagonal mesophases, which be tailored controlled release. Further include the preparation membranes separation processes, wastewater treatment. Furthermore, these materials ion-conducting fuel cells lithium batteries due to broad types mesophases. This review aims provide an overall explanation classification polymers. great potential relies on range determined by unique properties. Moreover, this study provides latest advances polymer-based focusing especially cells. future directions highlighted.

Язык: Английский

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Nanotechnology-based liquid crystals used in biosensors

Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 611 - 629

Опубликована: Янв. 1, 2025

Язык: Английский

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Recent advances in the use of liquid crystalline nanoparticles for non-small cell lung cancer treatment

Expert Opinion on Drug Delivery, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Introduction Non-small cell lung cancer (NSCLC) continues to pose a considerable health challenge with few therapeutic alternatives. Liquid crystalline nanoparticles (LCN) are nanostructured drug delivery systems made of lipid-based amphiphilic materials that self-assemble into phases in aqueous environments. LCN have become promising way treat NSCLC owing their specific properties make them useful for targeted and controlled release.

Язык: Английский

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The impact of formulation design on the Oral bioavailability of Omega-3 polyunsaturated fatty acids

Food Research International, Год журнала: 2025, Номер unknown, С. 116171 - 116171

Опубликована: Март 1, 2025

Язык: Английский

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Enhancement of solubilization and transdermal delivery of methotrexate in microemulsions with natural deep eutectic solvents screened by COMSO-RS

Colloids and Surfaces A Physicochemical and Engineering Aspects, Год журнала: 2025, Номер unknown, С. 136798 - 136798

Опубликована: Март 1, 2025

Язык: Английский

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Self-assembled peptide hydrogels for the treatment of diabetes and associated complications

Colloids and Surfaces B Biointerfaces, Год журнала: 2024, Номер 235, С. 113761 - 113761

Опубликована: Янв. 21, 2024

Язык: Английский

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Liquid Crystalline Structures Formed by Sphere–Rod Amphiphilic Molecules in Solvents

Crystals, Год журнала: 2025, Номер 15(2), С. 177 - 177

Опубликована: Фев. 13, 2025

Self-assembly of amphiphilic molecules is an important phenomenon attracting a broad range research. In this work, we study the self-assembly KTOF4 sphere–rod in mixed water–dioxane solvents. The are T-shaped geometry, comprised hydrophilic spherical Keggin-type cluster attached by flexible bridge to center hydrophobic rod-like oligodialkylfluorene (OF), which consists four OF units. Transmission electron microscopy (TEM) uncovers self-assembled structures dilute solutions. These spheres filled with smectic-like layers separated solution. There two types layer packings: (i) concentric and (ii) flat layers. form when dioxane volume fraction solution 35–50 vol%. formed either below (20 30 vol%.) or above (55 60 indicated range. layered show no in-plane orientational order thus resemble thermotropic smectic A liquid crystals their lyotropic analogs. packings reveal edge screw dislocations. Evaporation solvent produces bulk birefringent crystal phase textures resembling ones uniaxial nematic crystals. findings demonstrate that produce variety controlled properties.

Язык: Английский

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Liquid crystalline coatings loaded with colistin for preventing development of biofilms on orthopedic implants

Journal of Colloid and Interface Science, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

The current antibacterial strategies focus on antibiotic therapy and extensive hygienic measures during orthopedic surgery. However, potential development of implant-associated infections remains a persistent clinical challenge. There is, therefore, growing interest in introducing innovative safe for preventing combating biofilm implants. Antibacterial coatings, particularly, are attractive local delivery agents. We aim this proof-of-concept study at novel translatable implant coating approach, focusing directed assembly inverse non-lamellar lyotropic liquid crystalline (LLC) nanostructures implants prevention initial bacterial attachment formation through the widely used cationic colistin (COL). On exposure dry lipid films deposited model to aqueous solutions COL prepared different concentrations, set LLC coatings based commercial distilled monoglyceride product (or glycerol monooleate) were produced. In addition small-angle X-ray scattering (SAXS) characterization investigations, vitro studies conducted evaluating antibiofilm properties against Gram-negative bacteria Pseudomonas aeruginosa. SAXS analysis indicated that all samples bicontinuous cubic Pn3m phases. Significant COL's activity efficient protection adhesion demonstrated with surface produced by using containing concentrations 50 500 µg/mL. serum, detected structural alterations changes also discussed. This highlights implications self-assemblies designing nanostructural implants, which can prevent

Язык: Английский

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