ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(51), С. 70378 - 70391
Опубликована: Дек. 12, 2024
Transdermal
insulin
delivery
in
a
painless,
convenient,
and
on-demand
way
remains
long-standing
challenge.
A
variety
of
smart
microneedles
(MNs)
fabricated
by
glucose-responsive
phenylboronic
acid
hydrogels
have
been
previously
developed
to
provide
painless
autonomous
release
response
glucose
level
change.
However,
like
the
majority
MNs,
their
transdermal
efficiency
was
still
relatively
low
compared
that
with
subcutaneous
injection.
Herein,
we
report
an
iontophoresis
(ITP)-integrated
MNs
platform
enhanced
depth.
Carbon
nanotubes
(CNTs)
were
induced
boronate-containing
hydrogel
develop
semi-interpenetrating
network
stiffness
conductivity.
Remarkably,
ITP
not
only
facilitated
efficient
deeper
via
electroosmosis
electrophoresis
but
also
well-maintained
responsiveness.
This
ITP-combined
platform,
which
could
safe
way,
is
promising
achieve
persistent
glycemic
control.
Furthermore,
payloads
wide
size
range
achieved
this
thus
shed
light
on
development
deep
skin
penetration
minimally
invasive
way.
Nucleic
acid
therapeutics
represent
a
highly
promising
treatment
approach
in
modern
medicine,
treating
diseases
at
the
genetic
level.
However,
these
face
numerous
challenges
practical
applications,
particularly
regarding
their
stability,
effectiveness,
cellular
uptake
efficiency,
and
limitations
delivering
them
specifically
to
target
tissues.
To
overcome
obstacles,
researchers
have
developed
various
innovative
delivery
systems,
including
viral
vectors,
lipid
nanoparticles,
polymer
inorganic
protein
carriers,
exosomes,
antibody
oligonucleotide
conjugates,
DNA
nanostructure-based
systems.
These
systems
enhance
therapeutic
efficacy
of
nucleic
drugs
by
improving
targeting
specificity,
half-life
vivo.
In
this
review,
we
systematically
discuss
different
types
drugs,
analyze
major
barriers
encountered
delivery,
summarize
current
research
progress
emerging
We
also
highlight
latest
advancements
application
for
diseases,
infectious
cancer,
brain
wound
healing.
This
review
aims
provide
comprehensive
overview
drug
systems'
status
future
directions
integrating
nanotechnology,
biomaterials
science,
gene
editing
technologies,
emphasizing
transformative
potential
precision
medicine.
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
178, С. 117219 - 117219
Опубликована: Июль 30, 2024
A
transdermal
delivery
system
offers
high
bioavailability
and
favorable
patient
adherence,
constituting
an
optimal
approach
for
localized
administration
in
rheumatoid
arthritis
(RA)
treatment.
However,
the
stratum
corneum
(SC)
impedes
efficiency
of
conventional
drug
systems.
Microneedles
(MNs)
can
temporarily
create
micropores
within
SC,
enabling
distribution
via
bypassing
this
barrier
enhancing
effectiveness.
Notably,
MNs
provide
a
painless
method
through
skin
may
directly
modulate
inflammation
immune
cells
by
delivering
drugs
lymphatic
during
administration.
MN
is
not
suitable
with
low
water
solubility
stability.
Additionally,
major
concerns
exist
regarding
safety
using
highly
cytotoxic
drugs,
given
that
it
could
result
local
concentration
at
site.
While
exhibit
some
degree
targeted
to
inflammatory
environment,
their
targeting
remains
suboptimal.
Nanoformulations
have
potential
significantly
address
limitations
RA
treatment
improving
targeting,
solubility,
stability,
biocompatibility.
Therefore,
review
provides
concise
overview
advantages,
disadvantages,
mechanisms
different
types
It
specifically
focuses
on
application
advantages
combining
nanoformulation
summarizes
current
trends
development
nanoformulations
combined
field
treatment,
offering
theoretical
support
future
advancements
clinical
applications.
Molecules,
Год журнала:
2025,
Номер
30(3), С. 512 - 512
Опубликована: Янв. 23, 2025
The
rise
of
antibiotic-resistant
Staphylococcus
aureus
strains,
particularly
MRSA,
complicates
the
management
skin
and
soft
tissue
infections.
This
review
highlights
ultrasonic
methodologies
as
adjunctive
therapies
to
combat
S.
aureus-driven
infections
prevent
progression
biofilm
formation
chronic
wounds.
Low-
high-frequency
ultrasound
(LFU
HFU)
demonstrate
potential
in
disrupting
biofilms,
enhancing
drug
delivery,
promoting
repair
through
cavitation
microbubble
activity.
These
approaches
integrate
frequencies
with
microbubbles
therapeutics,
such
antibiotics
affimers,
minimize
resistance
improve
healing.
Tailoring
bioeffects
on
structures
localized
delivery
technologies,
including
microneedle
patches
piezoelectric
systems,
presents
promising
solutions
for
early
intervention
structure
(SSSIs).
Pharmaceuticals,
Год журнала:
2025,
Номер
18(2), С. 195 - 195
Опубликована: Янв. 31, 2025
Drugs
administered
by
means
of
extravascular
routes
drug
administration
must
be
absorbed
into
the
systemic
circulation,
which
involves
movement
molecules
across
biological
barriers
such
as
epithelial
cells
that
cover
mucosal
surfaces
or
stratum
corneum
covers
skin.
Some
drugs
exhibit
poor
permeation
membranes
may
experience
excessive
degradation
during
first-pass
metabolism,
tends
to
limit
their
bioavailability.
Various
strategies
have
been
used
improve
Absorption
enhancement
include
co-administration
chemical
enhancers,
enzymes,
and/or
efflux
transporter
inhibitors,
changes,
and
specialized
dosage
form
designs.
Models
with
physiological
relevance
are
needed
evaluate
efficacy
absorption
techniques.
in
vitro
cell
culture
models
ex
vivo
tissue
explored
quantify
effectiveness
strategies.
This
review
deliberates
on
use
for
evaluation
selected
including
nasal,
oromucosal,
pulmonary,
oral,
rectal,
transdermal
administration.
Bioengineering,
Год журнала:
2025,
Номер
12(2), С. 179 - 179
Опубликована: Фев. 13, 2025
Regeneration
in
the
case
of
major
burn
subjects
must
involve
tissue
and
structural
regeneration,
but
also
functional
as
scars
derived
from
burns
often
compromise
motility.
Electromagnetic
fields
electrical
stimulation
may
be
a
possible
treatment
for
these
cases,
considering
they
cause
thermal
effect
magneto-mechanical
transduction
first
selective
second.
A
majorly
burned
woman
with
severe
motor
deficits,
treated
electromagnetic
vacuum,
associated
personalized
nutritional
program,
was
described.
The
latter
necessary
to
favor
weight
loss
preservation
weakened
structure.
Ultrasonography,
Doppler
ultrasound,
body
composition
were
measured.
Moreover,
postural
evaluation
performed.
Immediately
after
treatment,
restructuring
all
seen.
After
6
months,
regeneration
evident,
neo-angiogenesis.
From
point
view,
her
motility
improved,
she
stopped
using
walker.
combined
therapy
allows
obtain
unthinkable
results
short
time.
For
this
reason,
it
could
become
elective
scars.
Drug Design Development and Therapy,
Год журнала:
2025,
Номер
Volume 19, С. 1163 - 1183
Опубликована: Фев. 1, 2025
Infantile
hemangiomas
(IHs)
are
a
kind
of
skin
soft
tissue
benign
tumors
in
infants,
with
high
incidence
rate
and
significant
harm.
Rapid
early
proliferation
can
cause
severe
cosmetic
deformities
organ
development
disorders.
Propranolol
Hydrochloride
(PRH),
non-selective
adrenergic
β-receptor
blocker,
has
become
the
first-line
treatment
for
IHs
due
to
its
good
efficacy
safety
compared
other
drugs.
To
further
improve
bioavailability
PRH,
deliver
it
more
safely
effectively
lesion
site,
enhance
patient
compliance,
researchers
continually
developing
new
PRH
formulations
IHs.
This
article
briefly
introduced
pathogenesis
therapeutic
mechanism
PRH.
It
also
provided
detailed
overview
various
developed
over
past
12
years
IHs,
including
improved
oral
formulations,
topical
creams,
gels,
liposomes/nanoparticles,
transdermal
patches,
microneedles,
targeted
injectable
formulations.
summarized
prospects
technical
challenges
these
aims
provide
comprehensive
review
recent
advances
propranolol
technologies
treating
offering
reference
research
application.
At
same
time,
is
hoped
that
be
efficiently
used
clinical
practice
future.
