Current Overview on the Use of Nanosized Drug Delivery Systems in the Treatment of Neurodegenerative Diseases
ACS Omega,
Год журнала:
2024,
Номер
9(33), С. 35223 - 35242
Опубликована: Авг. 5, 2024
Neurodegenerative
diseases,
encompassing
conditions
such
as
Alzheimer's
disease,
Parkinson's
multiple
sclerosis,
amyotrophic
lateral
prion
and
Huntington's
present
a
growing
health
concern
human
life
expectancy
increases.
Despite
this,
effective
treatments
to
halt
disease
progression
remain
elusive
due
various
factors,
including
challenges
in
drug
delivery
across
physiological
barriers
like
the
blood-brain
barrier
patient
compliance
issues
leading
treatment
discontinuation.
In
response,
innovative
approaches
leveraging
noninvasive
techniques
with
higher
are
emerging
promising
alternatives.
This
Review
aims
synthesize
current
options
encountered
managing
neurodegenerative
while
also
exploring
modalities.
Specifically,
strategies
intranasal
administration
nanosized
systems
gaining
prominence
for
their
potential
enhance
efficacy
adherence.
Nanosized
systems,
liposomes,
polymeric
micelles,
nanoparticles,
evaluated
within
context
of
outstanding
studies.
The
advantages
disadvantages
these
discussed,
providing
insights
into
therapeutic
limitations.
Through
this
comprehensive
examination,
contributes
ongoing
discourse
surrounding
development
diseases.
Язык: Английский
Targeting the smooth muscle cell KEAP1-Nrf2-STING axis with pterostilbene attenuates abdominal aortic aneurysm
Phytomedicine,
Год журнала:
2024,
Номер
130, С. 155696 - 155696
Опубликована: Май 10, 2024
Язык: Английский
Topical delivery of pterostilbene nanoemulgel ameliorates imiquimod-induced psoriasis-like skin inflammation in mice
Nanomedicine,
Год журнала:
2025,
Номер
unknown, С. 1 - 12
Опубликована: Март 17, 2025
Aim
This
study
evaluates
the
therapeutic
potential
of
Pterostilbene
(PTN),
a
natural
stilbenoid,
in
an
imiquimod
(IMQ)-induced
psoriasis
model.
Due
to
PTN's
poor
solubility
and
bioavailability,
pterostilbene
nano-emulsion
gel
(PTN-NEG)
formulation
(0.1%
0.2%
w/w)
was
developed
enhance
its
efficacy.
Язык: Английский
Electrospun pullulan nanofibers containing pterostilbene-hydroxypropyl-β-cyclodextrin inclusion complex: Preparation and characterization
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 142978 - 142978
Опубликована: Апрель 1, 2025
Язык: Английский
Pterostilbene: A natural neuroprotective stilbene with anti-Alzheimer’s disease properties
Journal of Pharmaceutical Analysis,
Год журнала:
2024,
Номер
unknown, С. 101043 - 101043
Опубликована: Июль 1, 2024
Alzheimer's
disease
(AD)
is
the
leading
cause
of
dementia,
and
no
effective
treatment
has
been
developed
for
it
thus
far.
Recently,
use
natural
compounds
in
neurodegenerative
diseases
garnered
significant
attention
owing
to
their
minimal
adverse
reactions.
Accordingly,
potential
therapeutic
effect
pterostilbene
(PTS)
on
AD
demonstrated
multiple
vivo
vitro
experiments.
In
this
study,
we
systematically
reviewed
summarized
results
these
studies
investigating
PTS
treating
AD.
Analysis
literature
revealed
that
may
play
a
role
through
various
mechanisms,
including
anti-oxidative
damage,
anti-neuroinflammation,
anti-apoptosis,
cholinesterase
activity
inhibition,
attenuation
β-amyloid
deposition,
tau
protein
hyperphosphorylation.
Moreover,
interferes
with
progression
by
regulating
activities
peroxisome
proliferator-activated
receptor
alpha,
monoamine
oxidase
B,
Sirtuin-1,
phosphodiesterase
4A.
Furthermore,
further
elucidate
mechanisms
AD,
employed
network
pharmacology
molecular
docking
technology
perform
related
proteins,
obtained
binding
energies
ranged
from
−2.83
kJ/mol
−5.14
kJ/mol,
indicating
proteins
exhibit
good
ability
PTS.
Network
analysis
action
summary,
collating
summarizing
relevant
anticipated
will
serve
as
reference
precise
targeted
prevention
either
using
or
other
drug
interventions.
Язык: Английский