Curcumin nanocrystals ameliorate ferroptosis of diabetic nephropathy through glutathione peroxidase 4
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
15
Опубликована: Янв. 6, 2025
The
aim
of
this
study
was
to
investigate
the
effect
curcumin
nanocrystals
(Cur-NCs)
on
ferroptosis
in
high-glucose
(HG)-induced
HK-2
cells
and
streptozotocin
(STZ)-induced
diabetic
nephropathy
model
(DN)
rats.
purpose
is
determine
whether
Cur
NCs
can
become
a
promising
treatment
option
for
diabetes
by
reducing
ferroptosis.
Cur-NCs
were
prepared
using
microfluidic
technology
studied
dynamic
light
scattering
transmission
electron
microscopy.
treated
with
30
mM
HG
create
renal
tubule
damage
cell
model.
Then,
viability
evaluated
varying
concentrations
(0.23,
0.47,
0.94,
1.87,
3.75,
7.5,
15,
μg/mL)
Cell
Counting
Kit-8
(CCK-8).
Furthermore,
vivo
experiments
carried
out
roles
STZ-induced
DN
results
showed
that
greatly
enhanced
levels
LDH,
MDA,
Iron,
lipid
ROS,
apoptosis,
NCOA4,
TFR-1,
while
decreasing
expression
GSH,
GPX4,
SLC7A11,
FTH-1.
These
effects
induced
could
be
attenuated
Cur-NCs.
also
reduced
HG-induced
decrease
viability,
as
well
increase
ROS
however
erastin
inhibit
their
effects.
inhibited
This
demonstrates
significantly
attenuate
recovering
implying
may
therapy
DN.
Язык: Английский
Recent Advancement of Nanocrystal Dosage Forms
IntechOpen eBooks,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 3, 2025
Drug
nanocrystal
(NC)
is
a
formulation
approach,
which
has
been
extensively
exploited
to
enhance
drug
delivery
for
application
in
both
dissolution
rate
improvement
and
sustained
release
of
poorly
water-soluble
drugs
by
size
reduction
stabilization
the
particles.
Due
unique
physicochemical
pharmacokinetic
properties
NCs
entail,
versatility
be
incorporated
into
various
dosage
forms
different
disease
treatments,
ease
scalability
from
laboratory
development
optimization
setting
commercial
production
well-developed
manufacturing
technologies,
have
attracted
tremendous
industrial
interest,
reflected
increasing
financial
research
effort
over
last
decade.
This
chapter
intends
overview
as
viable
approach
with
introduction
on
important
aspects
principles
analytical
characterizations.
The
conventional
novel
methods
are
highlighted
an
emphasis
widely
used
wet
milling
high-pressure
homogenization
technologies.
recent
trends
utilized
pre-clinical
studies
clinical
trials
discussed
further.
In
addition,
currently
marketed
products
future
prospective
elaborated.
Язык: Английский
Manufacturing of Liposomes Using a Stainless-Steel Microfluidic Device: An Investigation into Design of Experiments
Langmuir,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 28, 2025
Liposomes
are
highly
beneficial
nanocarrier
systems
due
to
their
biocompatibility,
low
toxicity,
and
exceptional
inclusiveness,
which
lead
improved
drug
bioavailability.
For
biological
applications,
accurate
control
over
these
nanoparticles'
mean
size
distribution
is
essential.
Micromixers
facilitate
the
continuous
production
of
liposomes,
enhancing
precision
regulation
reproducibility.
In
this
research,
performance
a
stainless
steel
316L
micromixer
was
evaluated
by
using
COMSOL
Multiphysics
simulations.
The
liposomes
were
precisely
optimized
design
experiments
techniques
in
microfluidic
setup,
then
dexamethasone
sodium
phosphate
(DSP)
successfully
encapsulated
liposome
nanoparticles.
physicochemical
characteristics
such
as
ζ-potential,
size,
DSP
loading
capacity,
encapsulation
efficiency,
release,
assessed.
Transmission
electron
microscopy
dynamic
light
scattering
analysis
used
examine
structures
liposomes.
release
kinetics
study
conducted
analyze
delivery
system,
Higuchi
equation
determined
be
most
suitable
equation.
chip
shown
capable
creating
small-sized
with
small
130
nm,
exhibiting
monodispersed
polydispersity
populations.
Язык: Английский