Polyphenol Microneedles for Dermatological Therapy
Macromolecular Bioscience,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 28, 2025
Abstract
Dermatological
diseases
represent
one
of
the
most
prevalent
health
concerns
globally,
with
associated
care
and
treatment
costs
having
consistently
increased
over
past
decade.
Current
therapeutic
modalities,
including
topical
medications,
oral
pharmaceuticals,
physical
therapies,
frequently
face
challenges
such
as
inadequate
drug
absorption
substantial
adverse
effects.
Microneedles,
recognized
minimally
invasive
delivery
systems,
effectively
penetrate
cutaneous
barrier
to
enhance
permeability
efficacy.
Polyphenols—abundant
in
botanical
marine
sources—demonstrate
diverse
pharmacological
properties
encompassing
anti‐inflammatory
antioxidant
activities.
The
integration
polyphenols
microneedle
technology
has
emerged
a
promising
strategy
for
dermatological
conditions,
demonstrating
significant
clinical
potential.
This
review
examines
multifunctional
capabilities
polyphenol‐incorporated
microneedles
elucidates
their
mechanisms
action
managing
disorders.
Furthermore,
it
synthesizes
recent
progress
polyphenol‐based
applications
various
pathologies,
acne
vulgaris,
psoriasis,
atopic
dermatitis.
Finally,
current
is
discussed
proposed
future
research
directions
optimizing
polyphenol
systems
therapeutics.
Язык: Английский
Melatonin hyalurosomes as a powerful antioxidant for combating skin damage induced by UV radiation
Journal of Liposome Research,
Год журнала:
2025,
Номер
unknown, С. 1 - 16
Опубликована: Апрель 1, 2025
Extrinsic
skin
aging
is
caused
by
chronic
photodamage.
The
present
study
aims
to
inspect
the
role
of
nanoencapsulation
melatonin
(MEL)
in
hyalurosomes
combating
UVB-induced
damage
take
advantage
hydrating
penetration
enhancing
and
antiaging
effects
hyaluronic
acid
along
with
powerful
antioxidant
MEL.
Measurement
particle
size,
zeta
potential,
encapsulation
efficiency
vitro
MEL
release
were
carried
out.
vivo
photoprotective
tested
rats.
A
histopathological
examination
was
conducted,
anti-inflammatory
markers
measured
estimating
expression
P38
MAPK,
P-ERK
P-JNK.
Particle
size
potential
285.9
nm
-26.3
mV
95%
entrapment
provided
a
sustained
profile
for
48h.
In
vivo,
results
revealed
superior
effect
protecting
against
reducing
levels
inflammatory
mediators
like
TNF-α
IL6
compared
suspension.
However,
they
had
prominent
increasing
antioxidants.
These
findings
may
be
accredited
deposition
besides
as
tool.
Язык: Английский