Therapeutic Applications of Plant Virus Nanoparticles in Cancer Treatment and Nanomedicine

Indus journal of bioscience research., Год журнала: 2025, Номер 3(1), С. 429 - 437

Опубликована: Янв. 20, 2025

Plant virus nanoparticles (VNPs) are inexpensive to produce, dependable, and reusable have emerged as a versatile promising platform in nanomedicine, particularly cancer therapy. These biogenic nanostructures possess unique physicochemical properties, including biocompatibility, biodegradability, structural uniformity, making them ideal candidates for targeted drug delivery. The ability of such encapsulate chemotherapeutic agents functionalize with tumor-specific ligands facilitates precise delivery cancerous tissues, minimizing off-target effects enhancing therapeutic efficacy. In addition, plant viral vectors (VLPs) an attractive option causing anti-tumor immunity because they undoubtedly secure, harmless, suitable mass manufacture pharmacological adaptation. This review delves into the molecular architecture nanoparticles, their functional modifications, mechanisms by which interact cells. Additionally, it highlights preclinical studies emerging clinical applications, addressing both opportunities challenges translating VNPs from bench bedside. By exploring anticancer potentials VNPs, this paper aims underscore role shaping future sustainable, plant-derived nanotechnology oncology.

Язык: Английский

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Excipients for Cerium Dioxide Nanoparticle Stabilization in the Perspective of Biomedical Applications

Molecules, Год журнала: 2025, Номер 30(6), С. 1210 - 1210

Опубликована: Март 8, 2025

Rare earth metal nanoparticles, some of which are already widely used in medicine, growing interest the modern scientific community. One promising rare metals for biomedical applications is cerium, specifically its oxide form, characterized by a higher level stability and safety. According to number studies, cerium dioxide has wide range biological effects (regenerative, antimicrobial, antioxidant, antitumor), justifies potential application medicine. However, these their intensity vary significantly across studies. Since was it can be assumed that not only chemical formula important, but also physicochemical parameters nanoparticles obtained, consequently methods synthesis modification with use excipients. In this review, we considered possibilities using excipients (polyacrylate, polyvinylpyrrolidone, dextran, hyaluronic acid, chitosan, polycarboxylic acids, lecithin, phosphatidylcholine) context preserving properties, as well degree study combinations from point view prospect creating drugs based on applications.

Язык: Английский

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Targeting cuproptosis with nano material: new way to enhancing the efficacy of immunotherapy in colorectal cancer

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Дек. 3, 2024

Colorectal cancer has emerged as one of the predominant malignant tumors globally. Immunotherapy, a novel therapeutic methodology, opened up new possibilities for colorectal patients. However, its actual clinical efficacy requires further enhancement. Copper, an exceptionally crucial trace element, can influence various signaling pathways, gene expression, and biological metabolic processes in cells, thus playing critical role pathogenesis cancer. Recent studies have revealed that cuproptosis, mode cell death, holds promise to become potential target overcome resistance immunotherapy. This shows substantial combination treatment Conveying copper into tumor cells via nano-drug delivery system induce cuproptosis could offer strategy eliminating drug-resistant vastly improving immunotherapy while ultimately destroy tumors. Moreover, combining induction with other anti-tumor approaches such photothermal therapy, photodynamic chemodynamic therapy enhance effect. review aims illuminate practical significance cuproptosis-inducing nano-drugs immunotherapy, scrutinize current challenges limitations this thereby providing innovative thoughts references advancement cuproptosis-based strategies.

Язык: Английский

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Synthesis and Cytostatic Activity of Substituted Derivatives of Sodium 1-Amino-2-cyano-1,6-dioxo-4-{[3-(ethoxycarbonyl)thiophen-2-yl]amino}hexa-2,4-dien-3-olates

Russian Journal of General Chemistry, Год журнала: 2024, Номер 94(12), С. 3140 - 3148

Опубликована: Дек. 1, 2024

Язык: Английский

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