Potential of Chitosan/Gelatin-Based Nanofibers in Delivering Drugs for the Management of Varied Complications: A Review

Polymers, Год журнала: 2025, Номер 17(4), С. 435 - 435

Опубликована: Фев. 7, 2025

Drug delivery systems have revolutionized traditional drug administration methods by addressing various challenges, such as enhancing solubility, prolonging effectiveness, minimizing adverse effects, and preserving potency. Nanotechnology-based systems, particularly nanoparticles (NPs) nanofibers (NFs), emerged promising solutions for biomedicine delivery. NFs, with their ability to mimic the porous fibrous structures of biological tissues, garnered significant interest in drug-delivering applications. Biopolymers gelatin (Ge) chitosan (CH) gained much more attention due biocompatibility, biodegradability, versatility biomedical CH exhibits exceptional anti-bacterial activity, wound healing capabilities, whereas Ge provides good biocompatibility cell adhesion properties. Ge/CH-based NFs stimulate cellular connections facilitate tissue regeneration owing structural resemblance extracellular matrix. This review explores additive preparation, including electrospinning, force pinning, template synthesis, focusing on electrospinning factors influencing fiber structure. The properties CH, role release, formulation strategies, characterization techniques electrospun fibers are discussed. Furthermore, this addresses applications delivering active moieties management orthopedics regulatory considerations, along challenges related them. Thus, aims provide a comprehensive overview potential

Язык: Английский

Advanced 3D Materials for Corneal Stroma Regeneration: A Preclinical Progress

Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Corneal stromal defects cause global blindness and entail unmet solutions beyond transplants. This review highlights scaffolds, biomaterials, signaling cues in corneal stroma engineering to advance next-generation vision therapies.

Язык: Английский