Natural polysaccharide-small molecule smart responsive nanogels: Design, synthesis, and synergistic chemoimmunotherapy for tumors
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 140930 - 140930
Опубликована: Фев. 1, 2025
Язык: Английский
Swelling Behavior, Biocompatibility, and Controlled Delivery of Sodium–Diclofenac in New Temperature-Responsive P(OEGMA/OPGMA) Copolymeric Hydrogels
Gels,
Год журнала:
2025,
Номер
11(3), С. 201 - 201
Опубликована: Март 14, 2025
This
study
investigates
the
synthesis
and
properties
of
innovative
poly(oligo(alkylene
glycol))
methacrylate
hydrogels
synthesized
via
gamma
radiation-induced
copolymerization
crosslinking
oligo(ethylene
glycol)
(OEGMA)
oligo(propylene
(OPGMA)
at
varying
mole
fractions.
Our
primary
objective
is
to
investigate
impact
on
swelling
P(OEGMA/OPGMA)
compared
their
homopolymeric
counterparts,
namely,
POEGMA
POPGMA,
which
exhibit
distinct
volume
phase
transition
temperatures
(VPTTs)
around
70
13
°C,
respectively,
under
physiological
conditions.
To
this
end,
a
comprehensive
library
smart
methacrylate-based
hydrogel
biomaterials
was
developed,
featuring
detailed
data
behavior
across
different
copolymer
molar
ratios
temperature
ranges.
achieve
these
objectives,
we
conducted
analysis
wide
range
temperatures,
assessed
pH
sensitivity
hydrogels,
utilized
scanning
electron
microscopy
for
morphological
characterization,
performed
in
vitro
biocompatibility
assessment
through
cell
viability
hemolysis
assays,
employed
diclofenac
sodium
as
model
drug
control
delivery
testing.
findings
demonstrate
that
newly
P(OEGMA40/OPGMA60)
copolymeric
exhibits
desirable
characteristics,
with
VPTT
close
required
controlled
applications.
Язык: Английский
Flavonoid-Based Nanogels: A Comprehensive Overview
Gels,
Год журнала:
2025,
Номер
11(4), С. 267 - 267
Опубликована: Апрель 4, 2025
The
growing
field
of
nanotechnology
has
recently
given
much
attention
to
nanogels,
which
are
versatile
formulas
and
have
promising
biomedical
applications.
Nanogels
or
nanohydrogels
undergone
significant
development
in
various
fields
industrial
research
meet
increasing
demands,
such
as
pharmaceuticals,
cosmetics,
food,
genetic
engineering.
that
contain
flavonoids,
secondary
metabolites
found
plants,
starting
become
distinctive
reveal
their
unique
characteristics.
objective
the
article
is
provide
a
comprehensive
overview
recent
articles
on
flavonoid-based
emphasizing
general
aspects
regarding
nanogel
formulation
structural
characterization,
well
advancements
made
field.
In
conclusion,
this
outlines
up-to-date
developments
synthesis,
formulation,
therapeutic
applications
important
role
nanotechnology.
Язык: Английский