A design of Tetrastigma hemsleyanum's flavonoid loaded polyvinylpyrrolidone nanoparticles for improving its bioavailability and biological activities

Food Chemistry, Год журнала: 2025, Номер unknown, С. 143099 - 143099

Опубликована: Янв. 1, 2025

Язык: Английский

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Peptide‐Based Strategies in PLGA‐Enhanced Tumor Therapy

Journal of Peptide Science, Год журнала: 2025, Номер 31(6)

Опубликована: Апрель 23, 2025

ABSTRACT Peptide‐based therapeutics have gained attention in cancer treatment because of their good specificity, low toxicity, and ability to modulate immune responses. However, challenges such as enzymatic degradation poor bioavailability limit clinical application. Peptide‐functionalized poly(lactic‐co‐glycolic acid) (PLGA) systems emerged a transformative platform therapy that offers unique advantages, including enhanced stability, sustained release, precise delivery therapeutic agents. This review highlights the synergistic integration peptides with PLGA addresses key peptide‐based therapeutics. The application peptide‐functionalized encompasses diverse range strategies for therapy. In chemotherapy, disrupt critical tumor pathways, induce apoptosis, inhibit angiogenesis, demonstrating versatility targeting various aspects progression. immunotherapy, act antigens stimulate robust responses or checkpoint inhibitors restore T cell activity, overcoming evasion. These also harness permeability retention effect, facilitating preferential accumulation tissues while leveraging microenvironment (TME)‐responsive mechanisms, pH‐sensitive enzyme‐triggered drug achieve controlled, localized delivery. Collectively, represent promising, versatile approach integrates innovative highly specific, potent

Язык: Английский

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2-Amino-3-Chlorobenzoic Acid from Streptomyces coelicolor: A Cancer Antagonist Targeting PI3K/AKT Markers via miRNA Modulation

Pharmaceuticals, Год журнала: 2025, Номер 18(5), С. 620 - 620

Опубликована: Апрель 24, 2025

Background/Objectives: Actinomycetes, particularly species within the Streptomyces genus, are renowned for their ability to produce a wide array of bioactive molecules with therapeutic potential. This study aimed comprehensively investigate antimicrobial and anticancer properties coelicolor ERI-15, particular focus on purified compound, 2-amino-3-chlorobenzoic acid (2A3CB), its efficacy against microbial pathogens breast cancer cell lines. Methods: Antimicrobial compounds were produced through fermentation techniques isolated via column chromatography. Bioassay-guided fractionation was conducted Staphylococcus aureus (ATCC 25923), methicillin-resistant (MRSA), Escherichia coli 25922), Bacillus subtilis 441). Major fractions further using preparative thin-layer chromatography (TLC). The structures active elucidated spectral analyses including IR, mass spectrometry, 1H/13C NMR. compound 2A3CB (m/z 171) tested MDA-MB-231 3T3 Cytotoxicity assessed by MTT assay, apoptotic mechanisms explored proliferation assays, dual fluorescent staining, migration invasion analysis markers at mRNA protein levels. Results: exhibited strong cytotoxic effects cells, IC50 values 26 µM, 5 7.2 µM 24, 48, 72 h, respectively. It significantly inhibited migration, induced apoptosis caspase-mediated pathways. Expression levels PTEN, PCNA, BAX, STAT3 downregulated, suggesting inhibition metastasis suppression migration. Conclusions: results demonstrate that 2A3CB, derived from S. possesses potent properties. Its inhibit growth induce in cells highlights potential as natural candidate targeted treatment, progression.

Язык: Английский

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Integration of Transcriptome and Metabolome Provides Insights into Flavonoid Biosynthesis in Quinoa (Chenopodium quinoa Willd.) Responsive to Saline-alkali Stress

Plant Physiology and Biochemistry, Год журнала: 2025, Номер unknown, С. 109988 - 109988

Опубликована: Май 1, 2025

Язык: Английский

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