Incorporation of forsterite nanoparticles in a 3D printed polylactic acid/polyvinylpyrrolidone scaffold for bone tissue regeneration applications
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 141046 - 141046
Опубликована: Фев. 1, 2025
Язык: Английский
Multifunctional hydrogel targeting senescence to accelerate diabetic wound healing through promoting angiogenesis
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Март 6, 2025
Diabetic
wound
healing
remains
a
significant
clinical
challenge
because
of
hyperglycaemia-induced
cellular
senescence,
impaired
angiogenesis,
and
chronic
inflammation.
To
address
these
issues,
we
developed
multifunctional
hydrogel
(GelMA/PNS/Alg@IGF-1)
that
integrates
gelatine
methacryloyl
(GelMA),
Panax
notoginseng
saponins
(PNS),
sodium
alginate
microspheres
encapsulating
insulin-like
growth
factor-1
(IGF-1).
This
was
engineered
to
achieve
gradient
sustained
release
bioactive
agents
target
senescence
promote
vascular
repair.
In
vitro
studies
demonstrated
the
significantly
reduced
oxidative
stress,
suppressed
markers
senescence-associated
secretory
phenotypes,
restored
endothelial
cell
function
under
high-glucose
conditions
by
inhibiting
NF-κB
pathway
activation.
Transcriptomic
analysis
revealed
modulation
pathways
linked
inflammation,
apoptosis,
angiogenesis.
accelerated
diabetic
closure
in
rat
model
vivo
enhanced
collagen
deposition,
granulation
tissue
formation,
neovascularization.
Furthermore,
mitigated
stress
promoted
remodelling.
The
synergistic
effects
PNS
IGF-1
within
established
pro-regenerative
microenvironment
both
pathological
ageing
dysfunction.
These
findings
highlight
GelMA/PNS/Alg@IGF-1
as
promising
therapeutic
platform
for
management,
this
material
offers
dual
anti-senescence
proangiogenic
efficacy
overcome
complexities
healing.
Язык: Английский
Selenium-containing polyurethane nanofibers with MnO2 nanoparticles and gelsevirine promote diabetic wound healing by modulation of ROS and inflammation
Biomaterials Advances,
Год журнала:
2025,
Номер
unknown, С. 214289 - 214289
Опубликована: Март 1, 2025
Язык: Английский
Hydrogel Based on Adipose Tissue-Derived Extracellular Matrix Encapsulated with Microspheres Containing Epidermal Growth Factor (EGF) and Vascular Endothelial Growth Factor (VEGF) Accelerate Diabetic Wound Healing in a Rat Model
Bratislavské lekárske listy/Bratislava medical journal,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 7, 2025
Язык: Английский